Highlights

2020

• Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.
  Brenner E, Schörg BF, Ahmetlić F, Wieder T, Hilke FJ, Simon N, Schroeder C, ... ,Quintanilla-Martinez L, Pichler BJ, Kneilling M, Mocikat R, Röcken M
  Nat Commun. 2020 Mar; 11(1): 1335
• The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
  Fischer K, Fenzl A, Liu D, ..., Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD
  Nat Commun. 2020 May 8; 11(1):2306. doi: 10.1038/s41467-020-16230-8.
• Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
  Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, ... Auer M, Horn N, Klose F, Ueffing M, Boldt K, Lynn DJ, Kolch W
  Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9.

2018

• Linking imaging to omics utilizing image-guided tissue extraction.
  Disselhorst JA, Krueger MA, Ud-Dean SMM, Bezrukov I, Jarboui MA, Trautwein C, Traube A, Spindler C, Cotton JM, Leibfritz D, Pichler BJ
  Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2980-E2987.
• Oxygen-enhanced and dynamic contrast-enhanced optoacoustic tomography provide surrogate biomarkers of tumour vascular function, hypoxia and necrosis.
  Tomaszewski MR, Gehrung M, Joseph J, Quiros Gonzalez I, Disselhorst JA, Bohndiek SE
  Cancer Res. 2018 Oct 15;78(20):5980-5991.

2017

• Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.
  Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.
  Nat Med. May;23(5):601-610
• Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography.
  Thunemann M, Schörg BF, Feil S, Lin Y, Voelkl J, Golla M, Vachaviolos A, Kohlhofer U, Quintanilla-Martinez L, Olbrich M, Ehrlichmann W, Reischl G, Griessinger CM, Langer HF, Gawaz M, Lang F, Schäfers M, Kneilling M, Pichler BJ, Feil R
  Nat Commun. Sep 5;8(1):444
• Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.
  Davies G, Rolle AM, Maurer A, Spycher PR, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR
  Theranostics. Aug 11;7(14):3398-3414

2016

• Decoding intratumoral heterogeneity of breast cancer by multiparametric in vivo imaging: A translational study.
  Schmitz J, Schwab J, Schwenck J, Chen Q, Quintanilla-Martinez L, Hahn M, Wietek B, Schwenzer N, Staebler A, Kohlhofer U, Aina OH, Hubbard NE, Reischl G, Borowsky AD, Brucker S, Nikolaou K, La Fougère C, Cardiff RD, Pichler BJ, Schmid AM
  Cancer Res. 2016 Sep 15;76(18):5512-22.
• ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo
  Rolle AM, Hasenberg M, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M, Wiehr S.
  Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33

2015

• 64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET
  Griessinger CM, Maurer A, Kesenheimer C, Kehlbach R, Reischl G, Ehrlichmann W, Bukala D, Harant M, Cay F, Brück J, Nordin R, Kohlhofer U, Rammensee HG, Quintanilla-Martinez L, Schaller M, Röcken M, Pichler BJ, Kneilling M.
  Proc Natl Acad Sci U S A. 2015 Jan 27. 112(4):1161-6.

2014

• Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion
  Maier FC, Wehrl HF, Schmid AM, Mannheim JG, Wiehr S, Lerdkrai C, Calaminus C, Stahlschmidt A, Ye L, Burnet M, Stiller D, Sabri O, Reischl G, Staufenbiel M, Garaschuk O, Jucker M, Pichler BJ.
  Nat Med. 2014 Dec. 20(12):1485-92.

2013

• Multimodal Elucidation of Choline Metabolism in a Murine Glioma Model using Magnetic Resonance Spectroscopy and 11C-choline Positron Emission Tomography
  Wehrl HF, Schwab J, Hasenbach K, Reischl G, Tabatabai G, Quintanilla-Martinez L, Jiru F, Chughtai K, Kiss A, Cay F, Bukala D, Heeren RM, Pichler BJ, Sauter AW.
  Cancer Res. 2013 Mar 1. 73(5):1470-80.
• Simultaneous PET/MR reveals Brain Function in Activated and Resting State on Metabolic, Hemodynamic and Multiple Temporal Scales
  Wehrl HF, Hossain M, Lankes K, Liu C-C, Bezrukov I, Martirosian P, Schick F, Reischl G, Pichler BJ.
  Nat. Med. 2013 Sep. 19(9): 1184-9

2009

• Direct Crosstalk between Mast Cell-TNF and TNFR1-expressing Endothelia Mediates Local Tissue Inflammation
  M. Kneilling , R. Mailhammer, L. Hültner, T. Schönberger, K. Fuchs, M. Schaller, D. Bukala, S. Massberg, C.A. Sander, M. Eichner, K.L. Maier, R. Hallmann, B.J. Pichler, R. Haubner, M. Gawaz, K. Pfeffer, T. Biedermann, M. Röcken
  Blood. 2009 Aug 20;114(8):1696-706.

2008

• Simultaneous PET/MRI: A new approach for functional and morphological imaging
  M.S. Judenhofer, H.F. Wehrl, D.F. Newport, C. Catana, S.B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Röcken, R.E. Nutt, H.-J. Machulla, K. Uludag, S.R. Cherry, C.D. Claussen, B.J. Pichler
  Nat Med. 2008 Apr;14(4):459-65.