Highlights

2025

• Exploring molecular imaging to investigate immune checkpoint inhibitor-related toxicity.
  Peeters E, van Genugten EAJ, Heskamp S, de Vries IJM, van Herpen C, Koenen HJPM, Kneilling M, van der Post RS, van Dop WA, Westdorp H, Aarntzen E.
  J Immunother Cancer. 2025 May 7;13(5):e011009.
• n vivo molecular imaging of breast cancer metabolic heterogeneity using [1-13C]pyruvate-d3 hyperpolarized by reversible exchange with parahydrogen.
  Petersen S, Nagel L, Groß PR, de Maissin H, Willing R, Heß L, Mitschke J, Klemm N, Treiber J, Müller CA, Knecht S, Schwartz I, Weigt M, Bock M, von Elverfeldt D, Zaitsev M, Chekmenev EY, Hövener JB, Martins AF, Schilling F, Reinheckel T, Schmidt AB.
  Theranostics. 2025 Mar 3;15(9):3714-3723.

2024

• Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy.
  Meraz-Torres F, Niessner H, Plöger S, Riel S, Schörg B, Casadei N, Kneilling M, Schaller M, Flatz L, Macek B, Eigentler T, Rieß O, Garbe C, Amaral T, Sinnberg T.
  J Exp Clin Cancer Res. 2024 Jan 23;43(1):30.
• A novel approach to guide GD2-targeted therapy in pediatric tumors by PET and [64Cu]Cu-NOTA-ch14.18/CHO.
  Trautwein NF, Schwenck J, Seitz C, Seith F, Calderón E, von Beschwitz S, Singer S, Reischl G, Handgretinger R, Schäfer J, Lang P, Pichler BJ, Schulte JH, la Fougère C, Dittmann H.
  Theranostics. 2024 Jan 20;14(3):1212-1223.
• Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies.
  Zekri L, Hagelstein I, Märklin M, Klimovich B, Christie M, Lindner C, Kämereit S, Prakash N, Müller S, Stotz S, Maurer A, Greve C, Schmied B, Atar D, Rammensee HG, Jung G, Salih HR.
  Sci Transl Med. 2024 Mar 6;16(737):eadh1988.
• Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.
  Joseph-Mathurin N, Feldman RL, Lu R, Shirzadi Z, ... , Reischl G, ... , Benzinger TLS; Dominantly Inherited Alzheimer Network.
  Alzheimers Dement. 2024 Apr;20(4):2680-2697.
• A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
  Gallage S, Ali A, Barragan Avila JE, ..., Joerke V, Zizmare L, ... , Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M.
  Cell Metab. 2024 Jun 4;36(6):1371-1393.e7.
• Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration.
  Webb EW, Cheng K, Winton WP, Klein BJC, Bowden GD, Horikawa M, Liu SW, Wright JS, Verhoog S, Kalyani D, Wismer M, Krska SW, Sanford MS, Scott PJH.
  J Am Chem Soc. 2024 Apr 17;146(15):10581-10590.
• A Macrocyclic Hybrid PET/MRI Probe for Quantitative Perfusion Imaging In Vivo.
  Kretschmer J, Chiaffarelli R, Vuozzo M, Cotton J, Blahut J, Ráliš J, Dračínský M, Matějková S, Seeling U, Schmid AM, Martins AF, Polasek M.
  Angew Chem Int Ed Engl. 2024 Nov 25;63(48):e202409520.
• In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy.
  Pezzana S, Blaess S, Kortendieck J, Hemmer N, Tako B, Pietura C, Ruoff L, Riel S, Schaller M, Gonzalez-Menendez I, Quintanilla-Martinez L, Mascioni A, Aivazian A, Wilson I, Maurer A, Pichler BJ, Kneilling M, Sonanini D.
  Theranostics. 2024 Aug 1;14(12):4582-4597.
• Functional PET/MRI reveals active inhibition of neuronal activity during optogenetic activation of the nigrostriatal pathway.
  Haas S, Bravo F, Ionescu TM, Gonzalez-Menendez I, Quintanilla-Martinez L, Dunkel G, Kuebler L, Hahn A, Lanzenberger R, Weigelin B, Reischl G, Pichler BJ, Herfert K.
  Sci Adv. 2024 Oct 25;10(43):eadn2776.

2023

• Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice
  Feil S, Stowbur D, Schörg BF, Ehrlichmann W, Reischl G, Kneilling M, Pichler BJ, Feil R
  Circ Res. 2023 Mar 17;132(6):747-750
• Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia
  Schütte JP, Manke MC, Hemmen K, Münzer P, Schörg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KAL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O
  Circ Res. 2023 Mar 31;132(7):e96-e113
• Advances in PET imaging of cancer.
  Schwenck J, Sonanini D, Cotton JM, Rammensee HG, la Fougère C, Zender L, Pichler BJ.
  Nat Rev Cancer. 2023 May 31.
• Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data.
  Katiyar P, Schwenck J, Frauenfeld L, Divine MR, Agrawal V, Kohlhofer U, Gatidis S, Kontermann R, Königsrainer A, Quintanilla-Martinez L, la Fougère C, Schölkopf B, Pichler BJ, Disselhorst JA.
  Nat Biomed Eng. 2023 Jun 5.
• In vivo imaging of CD8+ T cells in metastatic cancer patients: first clinical experience with simultaneous [89Zr]Zr-Df-IAB22M2C PET/MRI.
  Schwenck J, Sonanini D, Seyfried D, Ehrlichmann W, Kienzle G, Reischl G, Krezer P, Wilson I, Korn R, Gonzalez-Menendez I, Quintanilla-Martinez L, Seith F, Forschner A, Eigentler T, Zender L, Röcken M, Pichler BJ, Flatz L, Kneilling M, la Fougere C.
  Theranostics. 2023 Apr 17;13(8):2408-2423.
• Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling.
  Kotsiliti E, Leone V, Schuehle S, ... , Zizmare L, ... , Trautwein C, ..., Heikenwalder M.
  J Hepatol. 2023 May 9:S0168-8278(23)00325-2.
• A consensus protocol for functional connectivity analysis in the rat brain.
  Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, ... , Ionescu T, ...Marciano S., ..., Herfert K., ... ,Devenyi GA, Chakravarty MM, Hess A
  Nat Neurosci. 2023 Apr;26(4):673-681.
• Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.
  Singh Y, Trautwein C, Romani J, Salker MS, Neckel PH, Fraccaroli I, Abeditashi M, Woerner N, Admard J, Dhariwal A, Dueholm MKD, Schäfer KH, Lang F, Otzen DE, Lashuel HA, Riess O, Casadei N.
  Mol Neurodegener. 2023 Jul 4;18(1):44.
• Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
  McKay NS, Gordon BA, Hornbeck RC, ..., Rahmani F, Swisher L, ..., Farlow MR, la Fougère C, Fox NC, ..., Noble JM, Reischl G, Rowe C, Salloway S, Sanchez-Valle R, ..., Benzinger TLS; Dominantly Inherited Alzheimer Network.
  Nat Neurosci. 2023 Aug;26(8):1449-1460.
• Mapping tissue heterogeneity in solid tumours using PET-MRI and machine learning.
  Katiyar P, Pichler BJ
  Nat. Biomed. Eng 7, 969–970 (2023).
• Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
  Knopf P, Stowbur D, Hoffmann SHL, Hermann N, Maurer A, Bucher V, Poxleitner M, Tako B, Sonanini D, ..., Sinharay S, ..., Reckmann F, ..., Bhujwalla ZM, ..., Pagel MD, ...,Martins AF, Pichler BJ, ..., Kneilling M.
  Mol Cancer. 2023 Dec 15;22(1):207.
• Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients.
  Lichtensteiger C, Koblischke M, Berner F, ..., Kneilling M, Cozzio A, Pop O, Bomze D, Bergthaler A, Hasan Ali O, Aberle J, Flatz L.
  J Autoimmun. 2023 Oct 10;140:103118.
• Radiochemistry: A Hot Field with Opportunities for Cool Chemistry.
  Bowden GD, Scott PJH, Boros E.
  ACS Cent Sci. 2023 Nov 14;9(12):2183-2195.

2022

• 131I-GD2-ch14.18 Scintigraphy to Evaluate Option for Radioimmunotherapy in Patients with Advanced Tumors.
  Zhang Y, Kupferschlaeger J, Lang P, Reischl G, Handgretinger RJ, Fougère C, Dittmann H.
  J Nucl Med. 2022 Feb;63(2):205-211.
• Two experts and a newbie: [18F]PARPi vs [18F]FTT vs [18F]FPyPARP-a comparison of PARP imaging agents.
  Stotz S, Kinzler J, Nies AT, Schwab M, Maurer A.
  Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):834-846.
• Impact of 18F-FET PET/MRI on Clinical Management of Brain Tumor Patients.
  Brendle C, Maier C, Bender B, Schittenhelm J, Paulsen F, Renovanz M, Roder C, Castaneda-Vega S, Tabatabai G, Ernemann U, Fougère C.
  J Nucl Med. 2022 Apr;63(4):522-527.
• CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL.
  Montes-Mojarro IA, Steinhilber J, Griessinger CM, Rau A, Gersmann AK, Kohlhofer U, Fallier-Becker P, Liang HC, Hofmann U, Haag M, Klapper W, Schaeffeler E, Pichler BJ, Schwab M, Fend F, Bonzheim I, Quintanilla-Martinez L.
  Leukemia. 2022 Jun 8.
• Antibody-guided Molecular Imaging of Aspergillus Lung Infections in Leukemia Patients
  Schwenck J, Maurer A, Beziere N, Fiz F, Boschetti F, Geistlich S, Seyfried D, Gunzer M, Reischl G, Wehrmüller J, Ehrlichmann W, Horger M, Gatidis S, Davies G, Vogel W, la Fougere C, Pichler BJ, Thornton C
  J Nucl Med. 2022 Jul 21:jnumed.121.263251
• Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma
  Schmitt J, Schwenck J, Maurer A, Przybille M, Sonanini D, Reischl G, Wehrmuller JE, Quintanilla-Martinez L, Gillies SD, Krueger MA, Schaefer JF, la Fougere C, Handgretinger R, Pichler BJ
  Theranostics, 12 (12) , pp.5615-5630
• T cell-mediated additive cytotoxicity - death by multiple bullets
  Weigelin B, Friedl P
  Trends Cancer. 2022 Dec;8(12):980-987
• Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
  Marciano S, Ionescu TM, Saw RS, Cheong RY, Kirik D, Maurer A, Pichler BJ, Herfert K
  Proc Natl Acad Sci U S A. 2022 Oct 4;119(40)
• Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors
  Slaats J, Wagena E, Smits D, Berends AA, Peters E, Bakker GJ, van Erp M, Weigelin B, Adema GJ, Friedl P
  Cancer Immunol Res. 2022 Dec 2;10(12):1462-1474
• Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages
  He W, Henne A, Lauterbach M, Geißmar E, ... , Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K
  Nat Metab. 2022 May;4(5):524-533

2021

• Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans
  Stadlbauer A, Kinfe TM, Eyüpoglu I, Zimmermann M, Kitzwögerer M, Podar K, Buchfelder M, Heinz G, Oberndorfer S, Marhold F
  Clin Cancer Res. 2021 Mar 15;27(6):1641-1649
• A single pot template reaction towards a manganese based T1 contrast agent.
  Anbu S, Hoffmann SHL, Carniato F, Kenning L, Price TW, Prior TJ, Botta M, Martins AF, Stasiuk GJ
  Angew Chem Int Ed Engl. 2021 Feb 24. doi: 10.1002/anie.202100885. Epub ahead of print.
• Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment
  Henneberg S, Hasenberg A, Maurer A, Neumann F, Bornemann L, Gonzalez-Menendez I, Kraus A, Hasenberg M, Thornton CR, Pichler BJ, Gunzer M, Beziere N
  Nat Commun. 2021 Mar 17;12(1):1707
• The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
  Nording H, Baron L, Haberthür D, ... , Feil R, Pichler B, Erdmann J, ... , Gawaz M, Langer HF
  Nat Commun. 2021 Jun 7;12(1):3352
• Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery
  Slaats J, Dieteren CE, Wagena E, Wolf L, Raaijmakers TK, van der Laak JA, Figdor CG, Weigelin B, Friedl P
  Cancer Immunol Res. 2021 Jul 5
• LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
  Rudalska R, Harbig J, ... , Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D
  Nat Cancer. 2021 Feb;2(2):201-217
• Low-dose total body irradiation facilitates antitumoral Th1 immune responses
  Sonanini D, Griessinger CM, Schörg BF, Knopf P, Dittmann K, Röcken M, Pichler BJ, Kneilling M
  Theranostics. 2021 Jun 16;11(16):7700-7714
• Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.
  Weigelin B, den Boer AT, Wagena E, Broen K, Dolstra H, de Boer RJ, Figdor CG, Textor J, Friedl P
  Nat Commun. 2021 Sep 1;12(1):5217
• Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.
  Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender L.
  Nat Commun. 2021 Dec 1;12(1):7005.

2020

• Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.
  Brenner E, Schörg BF, Ahmetlić F, Wieder T, Hilke FJ, Simon N, Schroeder C, ... ,Quintanilla-Martinez L, Pichler BJ, Kneilling M, Mocikat R, Röcken M
  Nat Commun. 2020 Mar; 11(1): 1335
• The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
  Fischer K, Fenzl A, Liu D, ..., Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD
  Nat Commun. 2020 May 8; 11(1):2306. doi: 10.1038/s41467-020-16230-8.
• Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
  Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, ... Auer M, Horn N, Klose F, Ueffing M, Boldt K, Lynn DJ, Kolch W
  Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9.
• Is there a link between very early changes of primary and secondary lymphoid organs in 18 F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy?
  Seith F, Forschner A, Weide B, Gückel B, Schwartz M, Schwenck J, Othman AE, Fenchel M, Garbe C, Nikolaou K, Schwenzer N, la Fougère C, Pfannenberg C
  J Immunother Cancer. 2020 Aug;8(2):e000656. doi: 10.1136/jitc-2020-000656

2018

• Linking imaging to omics utilizing image-guided tissue extraction.
  Disselhorst JA, Krueger MA, Ud-Dean SMM, Bezrukov I, Jarboui MA, Trautwein C, Traube A, Spindler C, Cotton JM, Leibfritz D, Pichler BJ
  Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2980-E2987.
• Oxygen-enhanced and dynamic contrast-enhanced optoacoustic tomography provide surrogate biomarkers of tumour vascular function, hypoxia and necrosis.
  Tomaszewski MR, Gehrung M, Joseph J, Quiros Gonzalez I, Disselhorst JA, Bohndiek SE
  Cancer Res. 2018 Oct 15;78(20):5980-5991.

2017

• Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.
  Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.
  Nat Med. May;23(5):601-610
• Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography.
  Thunemann M, Schörg BF, Feil S, Lin Y, Voelkl J, Golla M, Vachaviolos A, Kohlhofer U, Quintanilla-Martinez L, Olbrich M, Ehrlichmann W, Reischl G, Griessinger CM, Langer HF, Gawaz M, Lang F, Schäfers M, Kneilling M, Pichler BJ, Feil R
  Nat Commun. Sep 5;8(1):444
• Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.
  Davies G, Rolle AM, Maurer A, Spycher PR, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR
  Theranostics. Aug 11;7(14):3398-3414

2016

• Decoding intratumoral heterogeneity of breast cancer by multiparametric in vivo imaging: A translational study.
  Schmitz J, Schwab J, Schwenck J, Chen Q, Quintanilla-Martinez L, Hahn M, Wietek B, Schwenzer N, Staebler A, Kohlhofer U, Aina OH, Hubbard NE, Reischl G, Borowsky AD, Brucker S, Nikolaou K, La Fougère C, Cardiff RD, Pichler BJ, Schmid AM
  Cancer Res. 2016 Sep 15;76(18):5512-22.
• ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo
  Rolle AM, Hasenberg M, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M, Wiehr S.
  Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33

2015

• 64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET
  Griessinger CM, Maurer A, Kesenheimer C, Kehlbach R, Reischl G, Ehrlichmann W, Bukala D, Harant M, Cay F, Brück J, Nordin R, Kohlhofer U, Rammensee HG, Quintanilla-Martinez L, Schaller M, Röcken M, Pichler BJ, Kneilling M.
  Proc Natl Acad Sci U S A. 2015 Jan 27. 112(4):1161-6.

2014

• Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion
  Maier FC, Wehrl HF, Schmid AM, Mannheim JG, Wiehr S, Lerdkrai C, Calaminus C, Stahlschmidt A, Ye L, Burnet M, Stiller D, Sabri O, Reischl G, Staufenbiel M, Garaschuk O, Jucker M, Pichler BJ.
  Nat Med. 2014 Dec. 20(12):1485-92.

2013

• Multimodal Elucidation of Choline Metabolism in a Murine Glioma Model using Magnetic Resonance Spectroscopy and 11C-choline Positron Emission Tomography
  Wehrl HF, Schwab J, Hasenbach K, Reischl G, Tabatabai G, Quintanilla-Martinez L, Jiru F, Chughtai K, Kiss A, Cay F, Bukala D, Heeren RM, Pichler BJ, Sauter AW.
  Cancer Res. 2013 Mar 1. 73(5):1470-80.
• Simultaneous PET/MR reveals Brain Function in Activated and Resting State on Metabolic, Hemodynamic and Multiple Temporal Scales
  Wehrl HF, Hossain M, Lankes K, Liu C-C, Bezrukov I, Martirosian P, Schick F, Reischl G, Pichler BJ.
  Nat. Med. 2013 Sep. 19(9): 1184-9

2009

• Direct Crosstalk between Mast Cell-TNF and TNFR1-expressing Endothelia Mediates Local Tissue Inflammation
  M. Kneilling , R. Mailhammer, L. Hültner, T. Schönberger, K. Fuchs, M. Schaller, D. Bukala, S. Massberg, C.A. Sander, M. Eichner, K.L. Maier, R. Hallmann, B.J. Pichler, R. Haubner, M. Gawaz, K. Pfeffer, T. Biedermann, M. Röcken
  Blood. 2009 Aug 20;114(8):1696-706.

2008

• Simultaneous PET/MRI: A new approach for functional and morphological imaging
  M.S. Judenhofer, H.F. Wehrl, D.F. Newport, C. Catana, S.B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Röcken, R.E. Nutt, H.-J. Machulla, K. Uludag, S.R. Cherry, C.D. Claussen, B.J. Pichler
  Nat Med. 2008 Apr;14(4):459-65.