Open-source flow setup for rapid and efficient [18 F]fluoride drying for automation of PET tracer syntheses.
Menzel F, Cotton J, Ziegler T, Maurer A, Neumaier JM.
J Labelled Comp Radiopharm. 2024 Feb;67(2):40-58.
Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy.
Meraz-Torres F, Niessner H, Plöger S, Riel S, Schörg B, Casadei N, Kneilling M, Schaller M, Flatz L, Macek B, Eigentler T, Rieß O, Garbe C, Amaral T, Sinnberg T.
J Exp Clin Cancer Res. 2024 Jan 23;43(1):30.
Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis.
Scheurer J, Sauer B, Focken J, Giampetraglia M, Jäger A, Schürch CM, Weigelin B, Schittek B.
Dis Model Mech. 2024 Jan 1;17(1):dmm050541.
A novel approach to guide GD2-targeted therapy in pediatric tumors by PET and [64Cu]Cu-NOTA-ch14.18/CHO.
Trautwein NF, Schwenck J, Seitz C, Seith F, Calderón E, von Beschwitz S, Singer S, Reischl G, Handgretinger R, Schäfer J, Lang P, Pichler BJ, Schulte JH, la Fougère C, Dittmann H.
Theranostics. 2024 Jan 20;14(3):1212-1223.
[18F]pFBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain.
Bowden GD, Stotz S, Dunkel G, Haas S, Kimmerle E, Schaller M, Weigelin B, Herfert K, Pichler BJ, Maurer A.
Bioconjug Chem. 2024 Feb 21;35(2):254-264.
Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake.
Yang Q, Deng S, Preibsch H, Schade TC, Koch A, Berezhnoy G, Zizmare L, Fischer A, Gückel B, Staebler A, Hartkopf AD, Pichler BJ, la Fougère C, Hahn M, Bonzheim I, Nikolaou K, Trautwein C.
Clin Transl Med. 2024 Feb;14(2):e1550.
Basic principles of artificial intelligence in dermatology explained using melanoma.
Hartmann T, Passauer J, Hartmann J, Schmidberger L, Kneilling M, Volc S.
J Dtsch Dermatol Ges. 2024 Mar;22(3):339-347.
Quantitative Metabolomics and Lipoprotein Analysis of PDAC Patients Suggests Serum Marker Categories for Pancreatic Function, Pancreatectomy, Cancer Metabolism, and Systemic Disturbances.
Bae G, Berezhnoy G, Flores A, Cannet C, Schäfer H, Dahlke MH, Michl P, Löffler MW, Königsrainer A, Trautwein C.
J Proteome Res. 2024 Apr 5;23(4):1249-1262.
Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies.
Zekri L, Hagelstein I, Märklin M, Klimovich B, Christie M, Lindner C, Kämereit S, Prakash N, Müller S, Stotz S, Maurer A, Greve C, Schmied B, Atar D, Rammensee HG, Jung G, Salih HR.
Sci Transl Med. 2024 Mar 6;16(737):eadh1988.
Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.
Joseph-Mathurin N, Feldman RL, Lu R, Shirzadi Z, ... , Reischl G, ... , Benzinger TLS; Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2024 Apr;20(4):2680-2697.
Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls.
Mannheim JG, Fu JF, Wegener T, Klyuzhin IS, Vafai N, Shahinfard E, McKenzie J, Strongosky A, Wszolek ZK, Jon Stoessl A, Sossi V.
Neuroimage Clin. 2024;42:103600.
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Gallage S, Ali A, Barragan Avila JE, ..., Joerke V, Zizmare L, ... , Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M.
Cell Metab. 2024 Jun 4;36(6):1371-1393.e7.
CD19-immunoPET for noninvasive visualization of CD19 expression in B-cell lymphoma patients.
Sonanini D, Schwenck J, Blaess S, Schmitt J, Maurer A, Ehrlichmann W, Ritter M, Skokowa J, Kneilling M, Jung G, Fend F, Krost S, Seitz CM, Lang P, Reischl G, Handgretinger R, Fougère C, Pichler BJ.
Biomark Res. 2024 May 12;12(1):50.
Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation-induced senescence.
Knopf P, Pacheco-Torres J, Zizmare L, Mori N, Wildes F, Zhou B, Krishnamachary B, Mironchik Y, Kneilling M, Trautwein C, Pichler BJ, Bhujwalla ZM.
NMR Biomed. 2024 Apr 8:e5157.
Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS.
Meng JH, Huang YB, Long J, Cai QC, Qiao X, Zhang QL, Zhang LD, Yan X, Jing R, Liu XS, Zhou SJ, Yuan YS, Yin-Chen Ma, Zhou LX, Peng NN, Li XC, Cai CH, Tang HM, Martins AF, Jiang JX, Kai-Jun Luo.
iScience. 2024 Mar 18;27(4):109469.
Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration.
Webb EW, Cheng K, Winton WP, Klein BJC, Bowden GD, Horikawa M, Liu SW, Wright JS, Verhoog S, Kalyani D, Wismer M, Krska SW, Sanford MS, Scott PJH.
J Am Chem Soc. 2024 Apr 17;146(15):10581-10590.
Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis.
Poxleitner M, Hoffmann SHL, Berezhnoy G, Ionescu TM, Gonzalez-Menendez I, Maier FC, Seyfried D, Ehrlichmann W, Quintanilla-Martinez L, Schmid AM, Reischl G, Trautwein C, Maurer A, Pichler BJ, Herfert K, Beziere N.
J Neuroinflammation. 2024 May 14;21(1):129.
Optimization and impact of sensitivity mode on abbreviated scan protocols with population-based input function for parametric imaging of [18F]-FDG for a long axial FOV PET scanner.
Lan W, Sari H, Rominger A, Fougère C, Schmidt FP.
Eur J Nucl Med Mol Imaging. 2024 May 20.
Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle.
Chen Y, Zizmare L, Calbiague V, Wang L, Yu S, Herberg FW, Schmachtenberg O, Paquet-Durand F, Trautwein C.
Elife. 2024 May 13;12:RP91141.
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury.
Köhler D, Leiss V, Beichert L, Killinger S, Grothe D, Kushwaha R, Schröter A, Roslan A, Eggstein C, Focken J, Granja T, Devanathan V, Schittek B, Lukowski R, Weigelin B, Rosenberger P, Nürnberg B, Beer-Hammer S.
Basic Res Cardiol. 2024 May 30.
Advancing Parkinson's Disease Diagnostics: The Potential of Arylpyrazolethiazole Derivatives for Imaging α-Synuclein Aggregates.
Bonanno F, Saw RS, Bleher D, Papadopoulos I, Bowden GD, Bjerregaard-Andersen K, Windhorst AD, Pichler BJ, Herfert K, Maurer A.
ACS Omega. 2024 May 30;9(23):24774-24788.
KCa channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by KCa expression levels.
Ganser K, Stransky N, Abed T, Quintanilla-Martinez L, Gonzalez-Menendez I, Naumann U, Koch P, Krueger M, Ruth P, Huber SM, Eckert F.
Int J Cancer. 2024 Jun 27.
Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization.
Kuntner C, Alcaide C, Anestis D, Bankstahl JP, Boutin H, Brasse D, Elvas F, Forster D, Rouchota MG, Tavares A, Teuter M, Wanek T, Zachhuber L, Mannheim JG.
Mol Imaging Biol. 2024 Jun 21.
Cerebrovascular Gi Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia
Castaneda-Vega S, Beer-Hammer S, Leiss V, Napieczyńska H, Vuozzo M, Schmid AM, Zeng H, He Y, Kohlhofer U, Gonzalez-Menendez I, Quintanilla-Martinez L, Hempel JM, Gollasch M, Yu X, Pichler BJ, Nürnberg B.
Mol Imaging Biol. 2023 Apr;25(2):363-374
First-in-Humans PET/MRI of In Vivo GD2 Expression in Osteosarcoma
Trautwein NF, Reischl G, Seitz C, Dittmann H, Seith F, Scheuermann S, Feuchtinger T, Dombrowski F, Handgretinger R, Fuchs J, Pichler B, Fougère C, Schwenck J
J Nucl Med. 2023 Feb;64(2):337-338
MR-spectroscopy in metachromatic leukodystrophy: A model free approach and clinical correlation
Feldmann J, Martin P, Bender B, Laugwitz L, Zizmare L, Trautwein C, Krägeloh-Mann I, Klose U, Groeschel S
Neuroimage Clin. 2023;37:103296
Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine
Ionescu TM, Amend M, Watabe T, Hatazawa J, Maurer A, Reischl G, Pichler BJ, Wehrl HF, Herfert K
J Nucl Med. 2023 Mar;64(3):466-471
Preclinical Identification Of Tumor-Draining Lymph Nodes Using a Multimodal Non-invasive In vivo Imaging Approach
Knopf P, Stowbur D, Hoffmann SHL, Fransen MF, Schwenck J, Pichler BJ, Kneilling M
Mol Imaging Biol. 2023 Jan 4, Epub ahead of print
TGF-Beta Modulates the Integrity of the Blood Brain Barrier In Vitro, and Is Associated with Metabolic Alterations in Pericytes
Schumacher L, Slimani R, Zizmare L, Ehlers J, Kleine Borgmann F, Fitzgerald JC, Fallier-Becker P, Beckmann A, Grißmer A, Meier C, El-Ayoubi A, Devraj K, Mittelbronn M, Trautwein C, Naumann U
Biomedicines. 2023 Jan 14;11(1):214
Radiolabeled GPVI-Fc for PET imaging of multiple extracellular matrix fibers: A new look into pulmonary fibrosis progression
Isser S, Maurer A, Reischl G, Schaller M, Gonzalez-Menendez I, Quintanilla-Martinez L, Gawaz M, Pichler BJ, Beziere N
J Nucl Med. 2023 Jan 26, Epub ahead of print
Design and performance simulation studies of a breast PET insert integrable into a clinical whole-body PET/MRI scanner
Pommranz CM, Schmidt FP, Mannheim JG, Diebold SJ, Tenzer C, Santangelo A, Pichler BJ
Phys Med Biol. 2023 Feb 28;68(5)
Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice
Feil S, Stowbur D, Schörg BF, Ehrlichmann W, Reischl G, Kneilling M, Pichler BJ, Feil R
Circ Res. 2023 Mar 17;132(6):747-750
Avascular fat grafts show lower volume retention but higher hypoxia, angiogenesis, adipocyte proliferation, and macrophage infiltration than vascularized adipocutaneous flaps in an in vivo pilot mouse study Fat grafting vs. flap transfer in mice
Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli AK, Schulte M, Hoffmann SH, Garvalov BK, Schreiber C, Takamiya M, Sleeman JP, Schmidt VJ, Kneser U, Pichler BJ, Dimmler A, Thiele W
Plast Reconstr Surg. 2023 Jan 3, Epub ahead of print
Imaging Techniques in Pharmacological Precision Medicine
Freidel L, Li S, Choffart A, Kuebler L, Martins AF
Handb Exp Pharmacol. 2023 Mar 13, Epub ahead of print
Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia
Schütte JP, Manke MC, Hemmen K, Münzer P, Schörg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KAL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O
Circ Res. 2023 Mar 31;132(7):e96-e113
Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke
Patzwaldt K, Berezhnoy G, Ionescu T, Schramm L, Wang Y, Owczorz M, Calderón E, Poli S, Serna Higuita LM, Gonzalez-Menendez I, Quintanilla-Martinez L, Herfert K, Pichler B, Trautwein C, Castaneda-Vega S
Brain Commun. 2023 Mar 29;5(2):fcad099
Machine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models.
Boeke S, Winter RM, Leibfarth S, Krueger MA, Bowden G, Cotton J, Pichler BJ, Zips D, Thorwarth D.
Eur J Nucl Med Mol Imaging. 2023 May 6.
Evaluation of a modular all-in-one high-resolution PET detector and readout electronics setup.
Schmidt FP, Krämer JC, Parl C, Schmand M, Pichler BJ.
Phys Med Biol. 2023 May 29;68(11).
The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β.
Di Nanni A, Saw RS, Bowden GD, Bidesi NSR, Bjerregaard-Andersen K, Korat Š, Herth MM, Pichler BJ, Herfert K, Maurer A.
Molecules. 2023 May 10;28(10):4001.
Advances in PET imaging of cancer.
Schwenck J, Sonanini D, Cotton JM, Rammensee HG, la Fougère C, Zender L, Pichler BJ.
Nat Rev Cancer. 2023 May 31.
Characterization of the partial volume effect along the axial field-of-view of the Biograph Vision Quadra total-body PET/CT system for multiple isotopes.
Mannheim JG, Rausch I, Conti M, la Fougère C, Schmidt FP.
EJNMMI Phys. 2023 May 27;10(1):33.
Stratification of ovarian cancer borderline from high-grade serous carcinoma patients by quantitative serum NMR spectroscopy of metabolites, lipoproteins, and inflammatory markers.
Bae G, Berezhnoy G, Koch A, Cannet C, Schäfer H, Kommoss S, Brucker S, Beziere N, Trautwein C.
Front Mol Biosci. 2023 Apr 19;10:1158330.
Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data.
Katiyar P, Schwenck J, Frauenfeld L, Divine MR, Agrawal V, Kohlhofer U, Gatidis S, Kontermann R, Königsrainer A, Quintanilla-Martinez L, la Fougère C, Schölkopf B, Pichler BJ, Disselhorst JA.
Nat Biomed Eng. 2023 Jun 5.
In vivo imaging of CD8+ T cells in metastatic cancer patients: first clinical experience with simultaneous [89Zr]Zr-Df-IAB22M2C PET/MRI.
Schwenck J, Sonanini D, Seyfried D, Ehrlichmann W, Kienzle G, Reischl G, Krezer P, Wilson I, Korn R, Gonzalez-Menendez I, Quintanilla-Martinez L, Seith F, Forschner A, Eigentler T, Zender L, Röcken M, Pichler BJ, Flatz L, Kneilling M, la Fougere C.
Theranostics. 2023 Apr 17;13(8):2408-2423.
Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome patients.
Berezhnoy G, Bissinger R, Liu A, Cannet C, Schäfer H, Kienzle K, Bitzer M, Häberle H, Göpel S, Trautwein C, Singh Y.
Front Immunol. 2023 May 9;14:1144224.
Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling.
Kotsiliti E, Leone V, Schuehle S, ... , Zizmare L, ... , Trautwein C, ..., Heikenwalder M.
J Hepatol. 2023 May 9:S0168-8278(23)00325-2.
PET/MRI and Bioluminescent Imaging Identify Hypoxia as a Cause of Programmed Cell Death Ligand 1 Image Heterogeneity.
Parkins KM, Krishnamachary B, Jacob D, Kakkad SM, Solaiyappan M, Mishra A, Mironchik Y, Penet MF, McMahon MT, Knopf P, Pichler BJ, Nimmagadda S, Bhujwalla ZM.
Radiol Imaging Cancer 2023 Jul;5(4):e220138.
A consensus protocol for functional connectivity analysis in the rat brain.
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, ... , Ionescu T, ...Marciano S., ..., Herfert K., ... ,Devenyi GA, Chakravarty MM, Hess A
Nat Neurosci. 2023 Apr;26(4):673-681.
Pyruvate-conjugation of PEGylated liposomes for targeted drug delivery to retinal photoreceptors.
Christensen G, Chen Y, Urimi D, Zizmare L, Trautwein C, Schipper N, Paquet-Durand F.
Biomed Pharmacother. 2023 Jul;163:114717.
Long-term prognostic factors for PRRT in neuroendocrine tumors.
Trautwein NF, Schwenck J, Jacoby J, Reischl G, Fiz F, Zender L, Dittmann H, Hinterleitner M, la Fougère C.
Front Med (Lausanne). 2023 Jun 9;10:1169970.
Diagnostic Performance of Dynamic Whole-Body Patlak [18F]FDG-PET/CT in Patients with Indeterminate Lung Lesions and Lymph Nodes.
Weissinger M, Atmanspacher M, Spengler W, Seith F, Von Beschwitz S, Dittmann H, Zender L, Smith AM, Casey ME, Nikolaou K, Castaneda-Vega S, la Fougère C.
J Clin Med. 2023 Jun 9;12(12):3942.
A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB.
Di Nanni A, Saw RS, Battisti UM, Bowden GD, Boeckermann A, Bjerregaard-Andersen K, Pichler BJ, Herfert K, Herth MM, Maurer A.
ACS Omega. 2023 Aug 15;8(34):31450-31467.
Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA.
Golombek S, Hoffmann T, Hann L, Mandler M, Schmidhuber S, Weber J, Chang YT, Mehling R, Ladinig A, Knecht C, Leyens J, Schlensak C, Wendel HP, Schneeberger A, Avci-Adali M.
Mol Ther Nucleic Acids. 2023 Aug 2;33:642-654.
Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future.
Lai J, Wang B, Petrik M, Beziere N, Hammoud DA.
J Infect Dis. 2023 Oct 3;228(Suppl 4):S259-S269.
The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection.
Alberto S, Ordonez AA, Arjun C, Aulakh GK, Beziere N, Dadachova E, Ebenhan T, Granados U, Korde A, Jalilian A, Lestari W, Mukherjee A, Petrik M, Sakr T, Cuevas CLS, Welling MM, Zeevaart JR, Jain SK, Wilson DM.
Nucl Med. 2023 Nov;64(11):1676-1682.
Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes.
Focken J, Scheurer J, Jäger A, Schürch CM, Kämereit S, Riel S, Schaller M, Weigelin B, Schittek B.
Cell Rep. 2023 Oct 31;42(10):113148.
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.
Singh Y, Trautwein C, Romani J, Salker MS, Neckel PH, Fraccaroli I, Abeditashi M, Woerner N, Admard J, Dhariwal A, Dueholm MKD, Schäfer KH, Lang F, Otzen DE, Lashuel HA, Riess O, Casadei N.
Mol Neurodegener. 2023 Jul 4;18(1):44.
Measuring the Release of Lactate from Wild-Type and rd1 Mouse Retina.
Chen Y, Zizmare L, Trautwein C, Paquet-Durand F.
Adv Exp Med Biol. 2023;1415:429-434.
Metabolomic profiling of CSF and blood serum elucidates general and sex-specific patterns for mild cognitive impairment and Alzheimer's disease patients.
Berezhnoy G, Laske C, Trautwein C.
Front Aging Neurosci. 2023 Aug 24;15:1219718.
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
McKay NS, Gordon BA, Hornbeck RC, ..., Rahmani F, Swisher L, ..., Farlow MR, la Fougère C, Fox NC, ..., Noble JM, Reischl G, Rowe C, Salloway S, Sanchez-Valle R, ..., Benzinger TLS; Dominantly Inherited Alzheimer Network.
Nat Neurosci. 2023 Aug;26(8):1449-1460.
Cell therapy by mesenchymal stromal cells versus myoblasts in a pig model of urinary incontinence.
Knoll J, Amend B, Harland N, Isser S, Beziere N, Kraushaar U, Stenzl A, Aicher W.
Tissue Eng Part A. 2023 Nov 7.
FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer.
Menzel F, Cotton J, Klein T, Maurer A, Ziegler T, Neumaier JM
J Flow Chem 13, 247–256 (2023).
Mapping tissue heterogeneity in solid tumours using PET-MRI and machine learning.
Katiyar P, Pichler BJ
Nat. Biomed. Eng 7, 969–970 (2023).
Non-invasive estimation of split renal function from routine 68Ga-SSR-PET/CT scans.
Weissinger M, Seyfried KC, Ursprung S, Castaneda-Vega S, Seith F, von Beschwitz S, Vogel J, Ghibes P, Nikolaou K, la Fougère C, Dittmann H.
Front Med (Lausanne). 2023 Jun 28;10:1169451.
The design of functional proteins using tensorized energy calculations.
Maksymenko K, Maurer A, Aghaallaei N, Barry C, Borbarán-Bravo N, Ullrich T, Dijkstra TMH, Hernandez Alvarez B, Müller P, Lupas AN, Skokowa J, ElGamacy M.
Cell Rep Methods. 2023 Aug 15;3(8):100560.
XBP1 promotes NRASG12D pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS.
Salimi A, Schemionek-Reinders M, Huber M, Vieri M, Patterson JB, Alten J, Brümmendorf TH, Kharabi Masouleh B, Appelmann I.
J Cell Mol Med. 2023 Nov;27(21):3363-3377.
Editorial: Imaging brain molecular connectivity in health and disease.
Sala A, Herfert K, Gonzalez-Escamilla G, Caminiti SP, Bertoglio D.
Front Hum Neurosci. 2023 Oct 10;17:1298382.
Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD+ pathway and SIRT1 activation.
Lonati C, Berezhnoy G, Lawler N, Masuda R, Kulkarni A, Sala S, Nitschke P, Zizmare L, Bucci D, Cannet C, Schäfer H, Singh Y, Gray N, Lodge S, Nicholson J, Merle U, Wist J, Trautwein C.
Clin Chem Lab Med. 2023 Nov 14.
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
Knopf P, Stowbur D, Hoffmann SHL, Hermann N, Maurer A, Bucher V, Poxleitner M, Tako B, Sonanini D, ..., Sinharay S, ..., Reckmann F, ..., Bhujwalla ZM, ..., Pagel MD, ...,Martins AF, Pichler BJ, ..., Kneilling M.
Mol Cancer. 2023 Dec 15;22(1):207.
Stratification of hypertension and SARS-CoV-2 infection by quantitative NMR spectroscopy of human blood serum.
Kazenwadel J, Berezhnoy G, Cannet C, Schäfer H, Geisler T, Rohlfing AK, Gawaz M, Merle U, Trautwein C.
Commun Med (Lond). 2023 Oct 16;3(1):145.
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients.
Lichtensteiger C, Koblischke M, Berner F, ..., Kneilling M, Cozzio A, Pop O, Bomze D, Bergthaler A, Hasan Ali O, Aberle J, Flatz L.
J Autoimmun. 2023 Oct 10;140:103118.
Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET/CT Scanner.
Calderón E, Schmidt FP, Lan W, Castaneda-Vega S, Brendlin AS, Trautwein NF, Dittmann H, la Fougère C, Kiefer LS.
Diagnostics (Basel). 2023 Oct 18;13(20):3240.
Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells.
Wagner TR, Blaess S, Leske IB, Frecot DI, Gramlich M, Traenkle B, Kaiser PD, Seyfried D, Maier S, Rezza A, Sônego F, Thiam K, Pezzana S, Zeck A, Gouttefangeas C, Scholz AM, Nueske S, Maurer A, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U.
Front Immunol. 2023 Dec 18;14:1264179.
Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner.
Linder PM, Lan W, Trautwein NF, Brosch-Lenz J, von Beschwitz S, Kupferschläger J, Reischl G, Grözinger G, Dittmann H, la Fougère C, Schmidt FP.
Diagnostics (Basel). 2023 Nov 9;13(22):3418.
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease.
Rahmani F, Brier MR, ..., Reischl G, Schofield PR, Oh H, Levin J, Vöglein J, Cash DM, Yakushev I, Ikeuchi T, Klunk WE, Morris JC, Bateman RJ, Benzinger TLS; Dominantly Inherited Alzheimer Network (DIAN).
Hum Brain Mapp. 2023 Dec 15;44(18):6375-6387.
On the Use of Artificial Intelligence for Dosimetry of Radiopharmaceutical Therapies.
Brosch-Lenz JF, Delker A, Schmidt F, Tran-Gia J.
Nuklearmedizin. 2023 Dec;62(6):379-388.
Evaluation of the MRI compatibility of PET detectors modules for organ-specific inserts in a 3T and 7T MRI scanner.
Schmidt FP, Allen MS, Ladebeck R, Breuer J, Judenhofer M, Schmand M, Catana C, Pichler BJ.
Med Phys. 2023 Dec 27.
Impact of the maximum ring difference on image quality and noise characteristics of a total-body PET/CT scanner.
Schmidt FP, Mannheim JG, Linder PM, Will P, Kiefer LS, Conti M, la Fougère C, Rausch I.
Z Med Phys. 2023 Oct 20:S0939-3889(23)00113-7.
Radiochemistry: A Hot Field with Opportunities for Cool Chemistry.
Bowden GD, Scott PJH, Boros E.
ACS Cent Sci. 2023 Nov 14;9(12):2183-2195.
Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling.
Stadlbauer A, Kinfe TM, Zimmermann M, Eyüpoglu I, Brandner N, Buchfelder M, Zaiss M, Dörfler A, Brandner S.
J Cereb Blood Flow Metab. 2022 Mar;42(3):526-539.
131I-GD2-ch14.18 Scintigraphy to Evaluate Option for Radioimmunotherapy in Patients with Advanced Tumors.
Zhang Y, Kupferschlaeger J, Lang P, Reischl G, Handgretinger RJ, Fougère C, Dittmann H.
J Nucl Med. 2022 Feb;63(2):205-211.
Two experts and a newbie: [18F]PARPi vs [18F]FTT vs [18F]FPyPARP-a comparison of PARP imaging agents.
Stotz S, Kinzler J, Nies AT, Schwab M, Maurer A.
Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):834-846.
Physiological MRI of microvascular architecture, neovascularization activity, and oxygen metabolism facilitate early recurrence detection in patients with IDH-mutant WHO grade 3 glioma.
Stadlbauer A, Heinz G, Oberndorfer S, Zimmermann M, Kinfe TM, Buchfelder M, Dörfler A, Kremenevski N, Marhold F.
Neuroradiology. 2022 Feb;64(2):265-277.
Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment.
Trautwein C, Zizmare L, Mäurer I, Bender B, Bayer B, Ernemann U, Tatagiba M, Grau SJ, Pichler BJ, Skardelly M, Tabatabai G.
JCI Insight. 2022 Feb 8;7(3):e153526.
Impact of 18F-FET PET/MRI on Clinical Management of Brain Tumor Patients.
Brendle C, Maier C, Bender B, Schittenhelm J, Paulsen F, Renovanz M, Roder C, Castaneda-Vega S, Tabatabai G, Ernemann U, Fougère C.
J Nucl Med. 2022 Apr;63(4):522-527.
Thyroid Metastasis in Whole-Body 18F-FDG PET/CT Restaging of Small Cell Lung Cancer.
Vogel J, Tenev A, Solass W, Schwenck J, Dittmann H.
Clin Nucl Med. 2022 Jan 1;47(1):96-97.
NEMA NU 4-2008 performance evaluation and MR compatibility tests of an APD-based small animal PET-insert for simultaneous PET/MR imaging.
Disselhorst JA, Newport DF, Schmid AM, Schmidt FP, Parl C, Liu CC, Pichler BJ, Mannheim JG.
Phys Med Biol. 2022 Feb 16;67(4).
Editorial to the Special Issue Entitled "Imaging in Immunooncology".
Fruhwirth GO, Weigelin B, Daldrup-Link HE, Ponomarev V.
Mol Imaging Biol. 2022 Apr;24(2):177-180.
Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis.
Griessinger J, Schwab J, Chen Q, Kühn A, Cotton J, Bowden G, Preibsch H, Reischl G, Quintanilla-Martinez L, Mori H, Dang AN, Kohlhofer U, Aina OH, Borowsky AD, Pichler BJ, Cardiff RD, Schmid AM.
NPJ Breast Cancer. 2022 Mar 24;8(1):41.
Quantitative Metabolomics of Tissue, Perfusate, and Bile from Rat Livers Subjected to Normothermic Machine Perfusion.
Lonati C, Dondossola D, Zizmare L, Battistin M, Wüst L, Vivona L, Carbonaro M, Zanella A, Gatti S, Schlegel A, Trautwein C.
Biomedicines. 2022 Feb 24;10(3):538.
Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations.
Zizmare L, Boyle CN, Buss S, Louis S, Kuebler L, Mulay K, Krüger R, Steinhauer L, Mack I, Rodriguez Gomez M, Herfert K, Ritze Y, Trautwein C.
Int J Mol Sci. 2022 Jan 20;23(3):1126.
Imaging the Rewired Metabolism in Lung Cancer in Relation to Immune Therapy.
van Genugten EAJ, Weijers JAM, Heskamp S, Kneilling M, van den Heuvel MM, Piet B, Bussink J, Hendriks LEL, Aarntzen EHJG.
Front Oncol. 2022 Jan 7;11:786089.
CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL.
Montes-Mojarro IA, Steinhilber J, Griessinger CM, Rau A, Gersmann AK, Kohlhofer U, Fallier-Becker P, Liang HC, Hofmann U, Haag M, Klapper W, Schaeffeler E, Pichler BJ, Schwab M, Fend F, Bonzheim I, Quintanilla-Martinez L.
Leukemia. 2022 Jun 8.
Dose escalation to hypoxic subvolumes in head and neck cancer: A randomized phase II study using dynamic [18F]FMISO PET/CT.
Welz S, Paulsen F, Pfannenberg C, Reimold M, Reischl G, Nikolaou K, La Fougère C, Alber M, Belka C, Zips D, Thorwarth D.
Radiother Oncol. 2022 Jun;171:30-36.
Antibody-guided Molecular Imaging of Aspergillus Lung Infections in Leukemia Patients
Schwenck J, Maurer A, Beziere N, Fiz F, Boschetti F, Geistlich S, Seyfried D, Gunzer M, Reischl G, Wehrmüller J, Ehrlichmann W, Horger M, Gatidis S, Davies G, Vogel W, la Fougere C, Pichler BJ, Thornton C
J Nucl Med. 2022 Jul 21:jnumed.121.263251
Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma
Schmitt J, Schwenck J, Maurer A, Przybille M, Sonanini D, Reischl G, Wehrmuller JE, Quintanilla-Martinez L, Gillies SD, Krueger MA, Schaefer JF, la Fougere C, Handgretinger R, Pichler BJ
Theranostics, 12 (12) , pp.5615-5630
Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging
Dao E, Clavijo Jordan MV, Geraki K, Martins AF, Chirayil S, Sherry AD, Farquharson MJ
J Trace Elem Med Biol. 2022 Dec;74:127054
T cell-mediated additive cytotoxicity - death by multiple bullets
Weigelin B, Friedl P
Trends Cancer. 2022 Dec;8(12):980-987
Identification of neurodegeneration indicators and disease progression in metachromatic leukodystrophy using quantitative NMR-based urinary metabolomics
Laugwitz L, Zizmare L, Santhanakumaran V, Cannet C, Böhringer J, Okun JG, Spraul M, Krägeloh-Mann I, Groeschel S, Trautwein C
JIMD Rep. 2022 Jan 27;63(2):168-180
A role for artificial intelligence in molecular imaging of infection and inflammation
Schwenck J, Kneilling M, Riksen NP, la Fougère C, Mulder DJ, Slart RJHA, Aarntzen EHJG
Eur J Hybrid Imaging. 2022 Sep 1;6(1):17
Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
Marciano S, Ionescu TM, Saw RS, Cheong RY, Kirik D, Maurer A, Pichler BJ, Herfert K
Proc Natl Acad Sci U S A. 2022 Oct 4;119(40)
Understanding the importance of quality control and quality assurance in preclinical PET/CT imaging
McDougald WA, Mannheim JG
EJNMMI Phys. 2022 Oct 31;9(1):77
Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model
Zizmare L, Mehling R, Gonzalez-Menendez I, Lonati C, Quintanilla-Martinez L, Pichler BJ, Kneilling M, Trautwein C.
Commun Biol. 2022 Nov 15;5(1):1250
Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma
Becker H, Castaneda-Vega S, Patzwaldt K, Przystal JM, Walter B, Michelotti FC, Canjuga D, Tatagiba M, Pichler B, Beck SC, Holland EC, la Fougère C, Tabatabai G
Brain Sci. 2022 Oct 24;12(11):1426
Spatiotemporal patterns of putaminal dopamine processing in Parkinson's disease: A multi-tracer positron emission tomography study
Fu JF, Wegener T, Klyuzhin IS, Mannheim JG, McKeown MJ, Stoessl AJ, Sossi V
Neuroimage Clin. 2022;36:103246
The Current Role of Peptide Receptor Radionuclide Therapy in Meningiomas
Fodi CK, Schittenhelm J, Honegger J, Castaneda-Vega SG, Behling F
J Clin Med. 2022 Apr 23;11(9):2364
Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG
Rausch I, Mannheim JG, Kupferschläger J, la Fougère C, Schmidt FP
EJNMMI Phys. 2022 Dec 14;9(1):87
Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors
Slaats J, Wagena E, Smits D, Berends AA, Peters E, Bakker GJ, van Erp M, Weigelin B, Adema GJ, Friedl P
Cancer Immunol Res. 2022 Dec 2;10(12):1462-1474
Quantitative Serum NMR Spectroscopy Stratifies COVID-19 Patients and Sheds Light on Interfaces of Host Metabolism and the Immune Response with Cytokines and Clinical Parameters
Rössler T, Berezhnoy G, Singh Y, Cannet C, Reinsperger T, Schäfer H, Spraul M, Kneilling M, Merle U, Trautwein C
Metabolites. 2022 Dec 16;12(12):1277
Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients
Yang Q, Bae G, Nadiradze G, Castagna A, Berezhnoy G, Zizmare L, Kulkarni A, Singh Y, Weinreich FJ, Kommoss S, Reymond MA, Trautwein C
Transl Med. 2022 Dec 12;20(1):581
Quantitative NMR-Based Lipoprotein Analysis Identifies Elevated HDL-4 and Triglycerides in the Serum of Alzheimer's Disease Patients
Berezhnoy G, Laske C, Trautwein C
Int J Mol Sci. 2022 Oct 18;23(20):12472
Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals
Korde A, Mikolajczak R, Kolenc P, Bouziotis P, Westin H, Lauritzen M, Koole M, Herth MM, Bardiès M, Martins AF, Paulo A, Lyashchenko SK, Todde S, Nag S, Lamprou E, Abrunhosa A, Giammarile F, Decristoforo C
EJNMMI Radiopharm Chem. 2022 Jul 19;7(1):18
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages
He W, Henne A, Lauterbach M, Geißmar E, ... , Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K
Nat Metab. 2022 May;4(5):524-533
Brain sex-dependent alterations after prolonged high fat diet exposure in mice
Murtaj V, Penati S, Belloli S, Foti M, Coliva A, Papagna A, Gotti C, Toninelli E, Chiaffarelli R, Mantero S, Pucci S, Matteoli M, Malosio ML, Moresco RM
Commun Biol. 2022 Nov 21;5(1):1276
The OpenGATE ecosystem for Monte Carlo simulation in medical physics
Sarrut D, Arbor N, Baudier T, Borys D, Etxebeste A, Fuchs H, Gajewski J, Grevillot L, Jan S, Kagadis GC, Kang HG, Kirov A, Kochebina O, Krzemien W, Lomax A, Papadimitroulas P, Pommranz C, Roncali E, Rucinski A, Winterhalter C, Maigne L
Phys Med Biol. 2022 Sep 8;67(18)
The Oncolytic Adenovirus XVir-N-31, in Combination with the Blockade of the PD-1/PD-L1 Axis, Conveys Abscopal Effects in a Humanized Glioblastoma Mouse Model
Klawitter M, El-Ayoubi A, Buch J, Rüttinger J, Ehrenfeld M, Lichtenegger E, Krüger MA, Mantwill K, Koll FJ, Kowarik MC, Holm PS, Naumann U
Int J Mol Sci. 2022 Sep 1;23(17):9965
Patient-individual phenotypes of glioblastoma stem cells are conserved in culture and associate with radioresistance, brain infiltration and patient prognosis
Ganser K, Eckert F, Riedel A, Stransky N, Paulsen F, Noell S, Krueger M, Schittenhelm J, Beck-Wödl S, Zips D, Ruth P, Huber SM, Klumpp L
Int J Cancer. 2022 May 15;150(10):1722-1733
Data on common carotid artery occlusion inducing focalized stroke lesions after Pertussis toxin injection
Leiss V, Piekorz RP, Vega SC, Jacoby C, Flögel U, Pexa K, Schrader J, Pichler BJ, Beer-Hammer S, Nürnberg B
Data Brief. 2022 Dec 25;46:108851
Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, Müller A, Fehrenbacher B, Gonzalez-Menendez I, Quintanilla-Martinez L, Schröder K, Brandes RP, Schaller M, Ruf W, Eichner M, Ghoreschi K, Röcken M, Pichler BJ, Kneilling M
Theranostics. 2021 Jan 1;11(2):470-490
Rapid and precise delivery of cells in the urethral sphincter complex by a novel needle-free waterjet technology
Linzenbold W, Jäger L, Stoll H, Abruzzese T, Harland N, Bézière N, Fech A, Enderle M, Amend B, Stenzl A, Aicher WK
BJU Int. 2021 Apr;127(4):463-472
Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients
Thaiss WM, Gatidis S, Sartorius T, Machann J, Peter A, Eigentler TK, Nikolaou K, Pichler BJ, Kneilling M
Cancer Immunol Immunother. 2021 May;70(5):1263-1275
[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates
Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K
Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1759-1772
Non invasive in vivo monitoring of dimethyl fumarate treatment in EAE by assessing the glucose metabolism in secondary lymphoid organs
Brück J, Calaminus C, Hoffmann SHL, Schwenck J, Holstein J, Yazdi AS, Pichler B, Kneilling M, Ghoreschi K
Eur J Immunol. 2021 Apr;51(4):1006-1009
An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer
Zekri L, Vogt F, Osburg L, Müller S, Kauer J, Manz T, Pflügler M, Maurer A, Heitmann JS, Hagelstein I, Märklin M, Hörner S, Todenhöfer T, Calaminus C, Stenzl A, Pichler B, la Fougère C, Schneider MA, Rammensee HG, Zender L, Sipos B, Salih HR, Jung G
EMBO Mol Med. 2021 Feb 5;13(2):e11902
Machine learning identifies stroke features between species
Castaneda-Vega S, Katiyar P, Russo F, Patzwaldt K, Schnabel L, Mathes S, Hempel JM, Kohlhofer U, Gonzalez-Menendez I, Quintanilla-Martinez L, Ziemann U, la Fougere C, Ernemann U, Pichler BJ, Disselhorst JA, Poli S
Theranostics. 2021 Jan 1;11(6):3017-3034. doi: 10.7150/thno.51887
Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI
Chirayil S, Jordan VC, Martins AF, Paranawithana N, Ratnakar SJ, Sherry AD
Inorg Chem. 2021 Jan 28. doi: 10.1021/acs.inorgchem.0c02688. Epub ahead of print
Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans
Stadlbauer A, Kinfe TM, Eyüpoglu I, Zimmermann M, Kitzwögerer M, Podar K, Buchfelder M, Heinz G, Oberndorfer S, Marhold F
Clin Cancer Res. 2021 Mar 15;27(6):1641-1649
A T 2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach
Zhang Y , Zhao K , He H , Wan S , Martins AF , Zhang L , Liu K
Dalton Trans. 2021 Feb 14;50(6):2014-2017
Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging
Mannheim JG, Cheng JK, Vafai N, Shahinfard E, English C, McKenzie J, Zhang J, Barlow L, Sossi V
EJNMMI Phys. 2021 Feb 26;8(1):20
A single pot template reaction towards a manganese based T1 contrast agent.
Anbu S, Hoffmann SHL, Carniato F, Kenning L, Price TW, Prior TJ, Botta M, Martins AF, Stasiuk GJ
Angew Chem Int Ed Engl. 2021 Feb 24. doi: 10.1002/anie.202100885. Epub ahead of print.
Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment
Henneberg S, Hasenberg A, Maurer A, Neumann F, Bornemann L, Gonzalez-Menendez I, Kraus A, Hasenberg M, Thornton CR, Pichler BJ, Gunzer M, Beziere N
Nat Commun. 2021 Mar 17;12(1):1707
Elucidating the complementarity of resting-state networks derived from dynamic [ 18 F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI
Ionescu TM, Amend M, Hafiz R, Biswal BB, Wehrl HF, Herfert K, Pichler BJ
Neuroimage. 2021 Apr 10;236:118045
[18F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the "Negative" Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients.
Smaxwil C, Aschoff P, Reischl G, Busch M, Wagner J, Altmeier J, Ploner O, Zielke A
J Clin Med. 2021 Apr 13;10(8):1648. doi: 10.3390/jcm10081648
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
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Nat Commun. 2021 Jun 7;12(1):3352
Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery
Slaats J, Dieteren CE, Wagena E, Wolf L, Raaijmakers TK, van der Laak JA, Figdor CG, Weigelin B, Friedl P
Cancer Immunol Res. 2021 Jul 5
Mathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells
Beck RJ, Weigelin B, Beltman JB
Cancers (Basel). 2021 May 24;13(11):2567
131Iodine-GD2-ch14.18 scintigraphy to evaluate option for radioimmunotherapy in patients with advanced tumors
Zhang Y, Kupferschlaeger J, Lang P, Reischl G, Handgretinger R, la Fougere C, Dittmann H
J Nucl Med. 2021 May 28:jnumed.120.261854
Central insulin modulates dopamine signaling in the human striatum
Kullmann S, Blum D, Jaghutriz BA, Gassenmaier C, Bender B, Häring HU, Reischl G, Preissl H, la Fougère C, Fritsche A, Reimold M, Heni M
J Clin Endocrinol Metab. 2021 Jun 15:dgab410
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
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Nat Cancer. 2021 Feb;2(2):201-217
Recent advances in intravital microscopy for preclinical research
Giampetraglia M, Weigelin B
Curr Opin Chem Biol. 2021 Aug;63:200-208
Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib
Bowden GD, Chailanggar N, Pichler BJ, Maurer A
Org Biomol Chem. 2021 Aug 28;19(32):6995-7000
Low-dose total body irradiation facilitates antitumoral Th1 immune responses
Sonanini D, Griessinger CM, Schörg BF, Knopf P, Dittmann K, Röcken M, Pichler BJ, Kneilling M
Theranostics. 2021 Jun 16;11(16):7700-7714
SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells
Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, Ossowski S, Salker MS, Casadei N, Riess O; Deutsche COVID-19 OMICS Initiate (DeCOI)
Heliyon. 2021 Jun;7(6):e07147
Glioma-Specific Diffusion Signature in Diffusion Kurtosis Imaging.
Hempel JM, Brendle C, Adib SD, Behling F, Tabatabai G, Castaneda Vega S, Schittenhelm J, Ernemann U, Klose U
Imaging. J Clin Med. 2021 May 26;10(11):2325
Synthesis and Biological Evaluation of a Radiolabeled PET (Positron Emission Tomography) Probe for Visualization of In Vivo α-Fucosidase Expression
Cotton J, Goehring CM, Kuehn A, Maurer A, Fuchs K, Pichler BJ
harmaceuticals (Basel). 2021 Jul 29;14(8):745
Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity.
Ionescu TM, Amend M, Hafiz R, Biswal BB, Maurer A, Pichler BJ, Wehrl HF, Herfert K.
Neuroimage. 2021 Nov;243:118501.
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.
Weigelin B, den Boer AT, Wagena E, Broen K, Dolstra H, de Boer RJ, Figdor CG, Textor J, Friedl P
Nat Commun. 2021 Sep 1;12(1):5217
A Protein-Based Biosensor for Detecting Calcium by Magnetic Resonance Imaging
Ozbakir HF, Miller ADC, Fishman KB, Martins AF, Kippin TE, Mukherjee A
ACS Sens. 2021 Sep 24;6(9):3163-3169.
Covalent 18F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging.
Stotz S, Bowden GD, Cotton JM, Pichler BJ, Maurer A.
Pharmaceuticals (Basel). 2021 Sep 3;14(9):897.
Alpha-Synuclein PET Tracer Development-An Overview about Current Efforts.
Korat Š, Bidesi NSR, Bonanno F, Di Nanni A, Hoàng ANN, Herfert K, Maurer A, Battisti UM, Bowden GD, Thonon D, Vugts D, Windhorst AD, Herth MM.
Pharmaceuticals (Basel). 2021 Aug 26;14(9):847.
The Role of Positron Emission Tomography/Computed Tomography (PET/CT) for Staging and Disease Response Assessment in Localized and Locally Advanced Pancreatic Cancer.
Ghidini M, Vuozzo M, Galassi B, Mapelli P, Ceccarossi V, Caccamo L, Picchio M, Dondossola D.
Cancers (Basel). 2021 Aug 18;13(16):4155.
Universal Gene Correction Approaches for β-hemoglobinopathies Using CRISPR-Cas9 and Adeno-Associated Virus Serotype 6 Donor Templates.
Lamsfus-Calle A, Daniel-Moreno A, Ureña-Bailén G, Rottenberger J, Raju J, Epting T, Marciano S, Heumos L, Baskaran P, S Antony J, Handgretinger R, Mezger M.
CRISPR J. 2021 Apr;4(2):207-222.
ADC-Based Stratification of Molecular Glioma Subtypes Using High b-Value Diffusion-Weighted Imaging.
Nuessle NC, Behling F, Tabatabai G, Castaneda Vega S, Schittenhelm J, Ernemann U, Klose U, Hempel JM.
J Clin Med. 2021 Aug 4;10(16):3451.
Detection of diabetes from whole-body MRI using deep learning.
Dietz B, Machann J, Agrawal V, Heni M, Schwab P, Dienes J, Reichert S, Birkenfeld AL, Häring HU, Schick F, Stefan N, Fritsche A, Preissl H, Schölkopf B, Bauer S, Wagner R.
JCI Insight. 2021 Nov 8;6(21):e146999.
DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer.
Bowden GD, Stotz S, Kinzler J, Geibel C, Lämmerhofer M, Pichler BJ, Maurer A.
J Med Chem. 2021 Nov 11;64(21):15690-15701.
Physiological MRI Biomarkers in the Differentiation Between Glioblastomas and Solitary Brain Metastases.
Heynold E, Zimmermann M, Hore N, Buchfelder M, Doerfler A, Stadlbauer A, Kremenevski N.
Mol Imaging Biol. 2021 Oct;23(5):787-795.
Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI.
Stadlbauer A, Marhold F, Oberndorfer S, Heinz G, Zimmermann M, Buchfelder M, Heynold E, Kinfe TM.
Metabolites. 2021 Sep 29;11(10):668.
Hypoxia and Microvascular Alterations Are Early Predictors of IDH-Mutated Anaplastic Glioma Recurrence.
Stadlbauer A, Oberndorfer S, Heinz G, Zimmermann M, Kinfe TM, Doerfler A, Buchfelder M, Kremenevski N, Marhold F.
Cancers (Basel). 2021 Apr 9;13(8):1797.
Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.
Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender L.
Nat Commun. 2021 Dec 1;12(1):7005.
Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells.
Traenkle B, Kaiser PD, Pezzana S, Richardson J, ... , Jakobi M, Schneiderhan-Marra N, Schaller M, Maurer A, Gouttefangeas C, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U.
Front Immunol. 2021 Dec 9;12:799910.
Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting
Seitz CM, Mittelstaet J, ... , Krahl AC, Knopf P, Schroeder S, ... , Schilbach K, Kneilling M, Pichler B, Lock D, Kotter B, Dapa S, Miltenyi S, Kaiser A, Lang P, Handgretinger R, Schlegel P
Oncoimmunology. 2021 Dec 2;10(1):2003532.
Advancing Biomarker Development Through Convergent Engagement: Summary Report of the 2nd International Danube Symposium on Biomarker Development, Molecular Imaging and Applied Diagnostics; March 14-16, 2018; Vienna, Austria.
Lim MS, Beyer T, Babayan A, Bergmann M, ..., Mitterhauser M, Pichler BJ, Salih HR, Schibli R, Schulz S, Simecek J, Simon J, Soares MO, Stelzl U, Wadsak W, Zatloukal K, Zeitlinger M, Hacker M
Mol Imaging Biol. 2020 Feb; 22(1):47-65
Imaging SERT Availability in a Rat Model of L-DOPA-Induced Dyskinesia.
Walker M, Kuebler L, Goehring CM, Pichler BJ, Herfert K
Mol Imaging Biol. 2020 Jun;22(3):634-642.
Temporal Dynamics of Reactive Oxygen and Nitrogen Species and NF-κB Activation During Acute and Chronic T Cell-Driven Inflammation.
Schwenck J, Mehling R, Thaiss WM, Kramer D, Menendez IG, Öz HH, Hartl D, Schulze-Osthoff K, Hailfinger S, Ghoreschi K, Quintanilla-Martinez L, Carlsen H, Röcken M, Pichler BJ, Kneilling M
Mol Imaging Biol. 2020 Jun;22(3):504-514.
PET/MRI enables simultaneous in vivo quantification of β-cell mass and function.
Michelotti FC, Bowden G, Küppers A, Joosten L, Maczewsky J, Nischwitz V, Drews G, Maurer A, Gotthardt M, Schmid AM, Pichler BJ
Theranostics 2020 Jan; 10(1):398-410.
Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo 18F-FDG-PET.
Schwenck J, Schörg B, Fiz F, Sonanini D, Forschner A, Eigentler T, Weide B, Martella M, Gonzalez-Menendez I, Campi C, Sambuceti G, Seith F, Quintanilla-Martinez L, Garbe C, Pfannenberg C, Röcken M, Fougere Cl, Pichler BJ, Kneilling M
Theranostics 2020 Jan; 10(2):925-937.
Selective protection of murine cerebral G(i/o)-proteins from inactivation by parenterally injected pertussis toxin.
Vega SC, Leiss V, Piekorz R, Calaminus C, Pexa K, Vuozzo M, Schmid AM, Devanathan V, Kesenheimer C, Pichler BJ, Beer-Hammer S, Nürnberg B
J Mol Med 2020 Jan; 98(1): 97-110
Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer.
Kaufmann S, Kruck S, Gatidis S, Hepp T, Thaiss WM, Hennenlotter J, Schwenck J, Scharpf M, Nikolaou K, Stenzl A, Reischl G, la Fougère C, Bedke J
World J Urol. 2020 Jan; [Epub ahead of print]
Circadian rhythm impacts preclinical FDG-PET quantification in the brain, but not in xenograft tumors.
Krueger MA, Calaminus C, Schmitt J, Pichler BJ
Sci Rep. 2020 Mar; 10(1): 5587
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.
Brenner E, Schörg BF, Ahmetlić F, Wieder T, Hilke FJ, Simon N, Schroeder C, ... ,Quintanilla-Martinez L, Pichler BJ, Kneilling M, Mocikat R, Röcken M
Nat Commun. 2020 Mar; 11(1): 1335
11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier.
Maurer A, Leonov A, Ryazanov S, Herfert K, Kuebler L, Buss S, Schmidt F, Weckbecker D, Linder R, Bender D, Giese A, Pichler BJ, Griesinger C
ChemMedChem. 2020 Mar; 15(5): 411-415
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
Fischer K, Fenzl A, Liu D, ..., Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD
Nat Commun. 2020 May 8; 11(1):2306. doi: 10.1038/s41467-020-16230-8.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, ... Auer M, Horn N, Klose F, Ueffing M, Boldt K, Lynn DJ, Kolch W
Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9.
Lactate production precedes inflammatory cell recruitment in arthritic ankles: an imaging study
Neveu MA, Beziere N, Daniels R, Bouzin C, Comment A, Schwenck J, Fuchs K, Kneilling M, Pichler BJ, Schmid AM
Mol Imaging Biol. 2020 Jun 8. doi: 10.1007/s11307-020-01510-y. Online ahead of print.
Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon
Walter A, Paul-Gilloteaux P, Plochberger B, Sefc L, Verkade P, Mannheim JG, Slezak P, Unterhuber A, Marchetti-Deschmann M, Ogris M, Bühler K, Fixler D, Geyer SH, Weninger WJ, Glösmann M, Handschuh S, Wanek T
Front. Phys., 09 April 2020 https://doi.org/10.3389/fphy.2020.00047
Modulating endothelial adhesion and migration impacts stem cell therapies efficacy
Schäfer R, Schwab M,Siegel G, von Ameln-Mayerhofer A, Buadzec M, Lourhmati A, Wendel H-P, Kluba T, Krueger, M A, Calaminus C, Scheer E, ... Claussen C D, Seifried E, Hermann D M, Northoff H, Danielyan L
EBioMedicine, Volume 60, 2020, 102987
DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)
Singh Y, Trautwein C, Dhariwal A, Salker MS, Alauddin Md, Zizmare L, Pelzl L, Feger M, Admard J, Casadei N, Föller M, Pachauri V, Park DS, Mak TW, Frick J-S, Wallwiener D, Brucker SY, Lang F, Riess O
Sci Rep . 2020 Sep 30;10(1):16131
Cell motility and migration as determinants of stem cell efficacy
Danielyan L, Schwab M, Siegel G, ... , Krueger MA, Calaminus C, Naumann U, Winter S, Schaeffeler E, Spogis A, Beer-Hammer S, ... , Hermann DM, Doeppner TR, Seifried E, Gleiter CH, Northoff H, Schäfer R.
EBioMedicine. 2020 Sep 10;60:102989. Online ahead of print.
Quo Vadis, Molecular Imaging?
Grimm J, Kiessling F, Pichler BJ
J Nucl Med . 2020 Oct;61(10):1428-1434. doi: 10.2967/jnumed.120.241984. Epub 2020 Aug 28
Comparison of patient stratification by computed tomography radiomics and hypoxia positron emission tomography in head-and-neck cancer radiotherapy
Socarrás Fernández JA, Mönnich D, Leibfarth S, Welz S, Zwanenburg A, Leger S, Löck S, Pfannenberg C, La Fougère C, Reischl G, Baumann M, Zips D, Thorwarth D
Phys Imaging Radiat Oncol. 2020 Jul;15:52-59.
Hydrojet-based delivery of footprint-free iPSC-derived cardiomyocytes into porcine myocardium
Weber M, Fech A, Jäger L, Steinle H, Bühler L, Perl RM, Martirosian P, Mehling R, Sonanini D, Aicher WK, Nikolaou K, Schlensak C, Enderle MD, Wendel HP, Linzenbold W, Avci-Adali M
Sci Rep. 2020 Oct 8;10(1):16787. doi: 10.1038/s41598-020-73693-x
Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D
Stotz S, Bleher D, Kalbacher H, Maurer A
Biochem Biophys Res Commun. 2020 Jun 18;527(1):238-241. doi: 10.1016/j.bbrc.2020.04.070. Epub 2020 May 1
Is there a link between very early changes of primary and secondary lymphoid organs in 18 F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy?
Seith F, Forschner A, Weide B, Gückel B, Schwartz M, Schwenck J, Othman AE, Fenchel M, Garbe C, Nikolaou K, Schwenzer N, la Fougère C, Pfannenberg C
J Immunother Cancer. 2020 Aug;8(2):e000656. doi: 10.1136/jitc-2020-000656
Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models
Gehrung M, Tomaszewski M, McIntyre D, Disselhorst J, Bohndiek S
Photoacoustics. 2020 Jan 16;18:100147. doi: 10.1016/j.pacs.2019.100147
Advances in the In Vivo Molecular Imaging of Invasive Aspergillosis
Gunzer M, Thornton CR, Bézière N
Fungi (Basel). 2020 Dec 4;6(4):338. doi: 10.3390/jof6040338
Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors
Bus C, Zizmare L, Feldkaemper M, ... , Rapaport D, Ueffing M, Casadei N, Krüger R, Gasser T, Vogt Weisenhorn DM, Kahle
iScience. 2020 Nov 13;23(12):101797. doi: 10.1016/j.isci.2020.101797
Non-Invasive Assessment of Hypoxia and Neovascularization with MRI for Identification of Aggressive Breast Cancer
Bennani-Baiti B, Pinker K, Zimmermann M, Helbich TH, Baltzer PA, Clauser P, Kapetas P, Bago-Horvath Z, Stadlbauer A
Cancers (Basel). 2020 Jul 24;12(8):2024
Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling
Stadlbauer A, Kinfe TM, Zimmermann M, Eyüpoglu I, Brandner N, Buchfelder M, Zaiss M, Dörfler A, Brandner S
J Cereb Blood Flow Metab. 2020 Aug 12:271678X20947546 doi: 10.1177/0271678X20947546. Epub ahead of print.
Correlation of C-arm CT acquired parenchymal blood volume (PBV) with 99mTc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up
Weissinger M, Vogel J, Kupferschläger J, Dittmann H, Castaneda Vega SG, Grosse U, Artzner C, Nikolaou K, la Fougere C, Grözinger G.
PLoS One. 2020 Dec 30;15(12)
Dual layer doI detector modules for a dedicated mouse brain PET/MRI.
Parl C, Kolb A, Stricker-Shaver D, Pichler BJ
Phys Med Biol. 2019 Feb 20;64(5):055004.
In Vivo Molecular Profiling of Human Glioma : Cross-Sectional Observational Study Using Dynamic Susceptibility Contrast Magnetic Resonance Perfusion Imaging.
Hempel JM, Schittenhelm J, Klose U, Bender B, Bier G, Skardelly M, Tabatabai G, Castaneda Vega S, Ernemann U, Brendle C
Clin Neuroradiol. 2019 Sep;29(3):479-491.
Acetuino-A Handy Open-Source Radiochemistry Module for the Preparation of [1-11C]Acetate.
Maurer A, Bowden G, Cotton J, Parl C, Krueger MA, Pichler BJ
SLAS Technol. 2019 Jun;24(3):321-329.
Comparative immuno-Cerenkov luminescence and -PET imaging enables detection of PSMA+ tumors in mice using 64Cu-radiolabeled monoclonal antibodies.
Maier FC, Wild AM, Kirchen N, Holm F, Fuchs K, Schwenck J, Maurer A, Wiehr S
Appl Radiat Isot. 2019 Jan;143:149-155.
Intention to treat analysis of 68Ga-PSMA and 11C-choline PET/CT versus CT for prostate cancer recurrences after surger.
Schwenck J, Olthof SC, Pfannenberg C, Reischl G, Wegener D, Marzec J, Bedke J, Atenzl A, la Fougère C, Zips D, Müller AC
J Nucl Med. 2019 Oct;60(10):1359-1365.
Prospective evaluation of a tumor control probability model based on dynamic 18F-FMISO PET for head-and-neck cancer radiotherapy.
Thorwarth D, Welz S, Mönnich D, Pfannenberg C, Nikolaou K, Reimold M, la Fougère C, Reischl G, Mauz PS, Paulsen F, Alber ML, Belka C, Zips D
J Nucl Med. 2019 Dec;60(12):1698-1704.
Targeting of the Cholecystokinin-2 Receptor with the Minigastrin Analog 177Lu-DOTA-PP-F11N: Does the Use of Protease Inhibitors Further Improve In Vivo Distribution?
Sauter AW, Mansi R, Hassiepen U, Muller L, Panigada T, Wiehr S, Wild AM, Geistlich S, Béhé M, Rottenburger C, Wild D, Fani M
J Nucl Med. 2019 Mar;60(3):393-399.
Smoking moderates association of 5-HTTLPR and in vivo availability of serotonin transporters.
Smolka MN, Reimold M, Kobiella A, Reischl G, Rietschel M, Heinz A
Eur Neuropsychopharmacol. 2019 Dec;29(2):171-178.
Retrobulbar Sinus Injection of Doxorubicin is More Efficient Than Lateral Tail Vein Injection at Inducing Experimental Nephrotic Syndrome in Mice: A Pilot Study.
Bohnert BN, Dörffel T, Daiminger S, Calaminus C, Aidone S, Falkenau A, Semrau A, Le MJ, Iglauer F, Artunc F
Lab Anim. 2019 Dec;53(6):564-576.
2-Nitroimidazole-Furanoside Derivatives for Hypoxia Imaging-Investigation of Nucleoside Transporter Interaction, F-Labeling and Preclinical PET Imaging.
Maier FC, Schweifer A, Damaraju VL, Cass CE, Bowden GD, Ehrlichmann W, Kneilling M, Pichler BJ, Hammerschmidt F, Reischl G
Pharmaceuticals (Basel). 2019 Feb 15;12(1).
Reproducibility and comparability of preclinical PET imaging data: A multi-center small animal PET study.
Mannheim JG, Mamach M, Reder S, Traxl A, Mucha N, Disselhorst JA, Mittelhäuser M, Kuntner C, Thackeray JT, Ziegler S, Wanek T, Bankstahl JP, Pichler BJ
J Nucl Med. 2019 Oct;60(10):1483-1491.
Evaluation of the therapeutic potential of the selective p38 MAPK inhibitor Skepinone-L and the dual p38/JNK 3 inhibitor LN 950 in experimental K/BxN serum transfer arthritis.
Guenthoer P, Fuchs K, Reischl G, Quintanilla-Martinez L, González-Menéndez I, Laufer S, Pichler BJ, Kneilling M
Inflammopharmacology. 2019 Dec;27(6):1217-1227.
Functional resting-state brain connectivity is accompanied by dynamic correlations of application-dependent [18F]FDG PET-tracer fluctuations.
Amend M, Ionescu TM, Di X, Pichler BJ, Biswal BB, Wehrl HF
Neuroimage. 2019 Aug 1;196:161-172.
The administration route of tumor-antigen-specific T-helper cells differentially modulates the tumor microenvironment and senescence.
Griessinger CM, Schmid AM, Sonanini D, Schörg BF, Jarboui MA, Bukala D, Mucha N, Fehrenbacher B, Steinhilber J, Martella M, Kohlhofer U, Schaller M, Zender L, Rammensee HG, Quintanilla-Martinez L, Röcken M, Kneilling M, Pichler BJ
Carcinogenesis. 2019 Apr 29;40(2):289-302.
Data Curation for Preclinical and Clinical Multimodal Imaging Studies.
Yamoah GG, Cao L, Wu CW, Beekman FJ, Vandeghinste B, Mannheim JG, Rosenhain S, Leonardic K, Kiessling F, Gremse F
Mol Imaging Biol. 2019 Dec;21(6):1034-1043.
Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix.
Beziere N, Fuchs K, Maurer M, Reischl G, Brück J, Ghoreschi K, Fehrenbacher B, Carvajal Berrio D, Schenke-Leyland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler BJ
Theranostics. 2019 Apr 13;9(10):2868-2881.
Enhanced Central Neural Gain Compensates Acoustic Trauma-induced Cochlear Impairment, but Unlikely Correlates with Tinnitus and Hyperacusis.
Möhrle D, Hofmeier B, Amend M, Wolpert S, Ni K, Bing D, Klose U, Pichler BJ, Knipper M, Rüttiger L
Neuroscience. 2019 May 21;407:146-169.
Fast enzymatic synthesis of n.c.a. 6-[18 F]fluorodopamine (FDA) from n.c.a. 6-[18 F]FDOPA and the fate of 6-FDOPA and 6-FDA in neuroblastoma and Caki-1 cells after their uptake.
Kuçi Z, Ehrlichmann W, Sauer J, Handgretinger R, Bruchelt G, Reischl G
J Labelled Comp Radiopharm. 2019 Jun 30;62(8):438-447.
Smart MRI Agents for Detecting Extracellular Events In Vivo: Progress and Challenges.
Parrott D, Shirangi Fernando W, Martins A
Inorganics 2019; 7(2), 18.
Quantitative Rodent Brain Receptor Imaging.
Herfert K, Mannheim JG, Kuebler L, Marciano S, Amend M, Parl C, Napieczynska H, Maier FM, Vega SC, Pichler BJ
Mol. Imaging Biol. 2019 Apr; 22(2):223-244.
A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo.
Paranawithana NN, Martins AF, Clavijo Jordan V, Zhao P, Chirayil S, Meloni G, Sherry AD
J Am Chem Soc. 2019 Jul 17;141(28):11009-11018.
Synchrotron Radiation X-ray Fluorescence Elemental Mapping in Healthy versus Malignant Prostate Tissues Provides New Insights into the Glucose-Stimulated Zinc Trafficking in the Prostate As Discovered by MRI.
Clavijo Jordan V, Al-Ebraheem A, Geraki K, Dao E, Martins AF, Chirayil S, Farquharson M, Sherry AD
Inorg Chem. 2019 Oct 21;58(20):13654-13660.
A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes.
Bowden GD, Pichler BJ, Maurer A
Sci Rep. 2019 Aug 6;9(1):11370.
Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging.
Di X, Wölfer M, Amend M, Wehrl H, Ionescu TM, Pichler BJ, Biswal BB
Hum Brain Mapp. 2019 Nov 1;40(16):4657-4668.
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Schwenck J, Maurer A, Fehrenbacher B, Mehling R, Knopf P, Mucha N, Haupt D, Fuchs K, Griessinger CM, ..., Röcken M, Kalbacher H, Pichler BJ, Kneilling M
Theranostics. 2019 May 31;9(13):3903-3917.
Weak Agonistic LPS Restores Intestinal Immune Homeostasis.
Steimle A, Michaelis L, Di Lorenzo F, Kliem T, Münzner T, Maerz JK, Schäfer A, Lange A, Parusel R, Gronbach K, Fuchs K, Silipo A, Öz HH, Pichler BJ, Autenrieth IB, Molinaro A, Frick JS
Mol Ther. 2019 Nov 6;27(11):1974-1991.
Visualization and quantification of in vivo homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer.
Hoffmann SHL, Reck D, Maurer A, Fehrenbacher B, Sceneay JE, Poxleitner M, Öz HH, Ehrlichmann W, Reischl G, Fuchs K, Schaller M, Hartl D, Kneilling M, Möller A, Pichler BJ, Griessinger CM
Theranostics. 2019 Aug 12;9(20):5869-5885.
Special Issue "Targets, Tracers and Translation Novel Radiopharmaceuticals Boost Nuclear Medicine"
Reischl G
Pharmaceuticals (Basel). 2019 Jul 18;12(3). pii: E111.
Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.
Charitou T, Srihari S, Lynn MA, Jarboui MA, Fasterius E, Moldovan M, Shirasawa S, Tsunoda T, Ueffing M, Xie J, Xin J, Wang X, Proud CG, Boldt K, Al-Khalili Szigyarto C, Kolch W, Lynn DJ
Br J Cancer. 2019 Jul;121(1):37-50.
GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells.
Seitz CM, Schroeder S, Knopf P, Krahl AC, Hau J, Schleicher S, Martella M, Quintanilla-Martinez L, Kneilling M, Pichler BJ, Lang P, Atar D, Schilbach K, Handgretinger R, Schlegel P
Oncoimmunology 2019 Nov; 9(1): 1683345
Assessment of Proteolytic Activities in the Bone Marrow Microenvironment.
Maurer A, Klein G, Staudt ND
Methods Mol Biol. 2019;2017:149-163.
The yin and yang of imaging tumor associated macrophages with PET and MRI.
Mukherjee S, Sonanini D, Maurer A, Daldrup-Link HE
Theranostics. 2019 Oct 15;9(25):7730-7748.
3D-printed standardized phantoms for small animal PET and MRI: a comparison study.
Zell F, Mannheim J, Grehn M, Rafecas M
Trans. AMMM 2019; 1(1)
A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer.
Rammensee HG, Wiesmüller KH, Chandran PA, Zelba H, Rusch E, Gouttefangeas C, Kowalewski DJ, ...,Schwenck J, Weber ANR, Pichler BJ, Kneilling M, la Fougère C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanović S, Löffler MW.
J Immunother Cancer. 2019 Nov; 7(1):307.
Standardization of Small Animal Imaging-Current Status and Future Prospects.
Mannheim JG, Kara F, Doorduin J, Fuchs K, Reischl G, Liang S, Verhoye M, Gremse F, Mezzanotte L, Huisman MC
Mol Imaging Biol. 2018 Oct;20(5):716-731
In vivo imaging of tumor-infiltrating immune cells: implications for cancer immunotherapy.
Zeelen C, Paus C, Draper D, Heskamp S, Signore A, Galli F, Griessinger CM, Aarntzen EH
Q J Nucl Med Mol Imaging. 2018 Mar;62(1):56-77.
CCR2-dependent Gr1high monocytes promote kidney injury in shiga toxin-induced hemolytic uremic syndrome in mice.
Pohl JM, Volke JK, Thiebes S, Brenzel A, Fuchs K, Beziere N, Ehrlichmann W, Pichler BJ, Squire A, Gueler F, Engel DR
Eur J Immunol. 2018 Jun;48(6):990-1000.
Evaluation of the accuracy of nine electronic apex locators by using Micro-CT.
Connert T, Judenhofer MS, Hülber-J M, Schell S, Mannheim JG, Pichler BJ, Löst C, ElAyouti A
Int Endod J. 2018 Feb;51(2):223-232.
Comparison of the Accuracy of FMT/CT and PET/MRI for the Assessment of Antibody Biodistribution in Squamous Cell Carcinoma Xenografts.
Hage C, Gremse F, Griessinger CM, Maurer A, Hoffmann SHL, Osl F, Pichler BJ, Kiessling F, Scheuer W, Pöschinger T
J Nucl Med. 2018 Jan;59(1):44-50.
Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany.
Bailey DL, Pichler BJ, Gueckel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I et al.
Mol Imaging Biol. 2018 Feb;20(1):4-20.
Optimization, evaluation and calibration of a cross-strip DOI detector.
Schmidt FP, Kolb A, Pichler BJ
Phys Med Biol. 2018 Feb 20;63(4):045022.
Impact of the AIF Recording Method on Kinetic Parameters in Small Animal PET.
Napieczynska H, Kolb A, Katiyar P, Tonietto M, Ud-Dean M, Stumm R, Herfert K, Calaminus C, Pichler B
J Nucl Med. 2018 Jul;59(7):1159-1164.
The effects of taxanes, vorinostat and doxorubicin on growth and proliferation of Echinococcus multilocularis metacestodes assessed with magnetic resonance imaging and simultaneous positron emission tomography.
Huang X, Wiehr S, Wild AM, Voßberg P, Hoffmann W, Grüner B, Köhler C, Soboslay PT
Oncotarget. 2018 Jan 10;9(10):9073-9087.
Tracking the fate of adoptively transferred myeloid-derived suppressor cells in the primary breast tumor microenvironment.
Sceneay J, Griessinger CM, Hoffmann SHL, Wen SW, Wong CSF, Krumeich S, Kneilling M, Pichler BJ, Möller A
PLoS One. 2018 Apr 20;13(4):e0196040.
Linking imaging to omics utilizing image-guided tissue extraction.
Disselhorst JA, Krueger MA, Ud-Dean SMM, Bezrukov I, Jarboui MA, Trautwein C, Traube A, Spindler C, Cotton JM, Leibfritz D, Pichler BJ
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2980-E2987.
Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM).
Nensa F, Bamberg F, Rischpler C, Menezes L, Poeppel TD, la Fougere C, Beitzke D, Rasul S, Loewe C, Nikolaou K, Bucerius J, Kjaer A, Gutberlet M, Prakken NH, Vliegenthart R, Slart RHJA, Nekolla SG, Lassen ML, Pichler BJ, Schlosser T, Jacquier A, et al.
Eur Radiol. 2018 Oct;28(10):4086-4101.
Glioma grading by dynamic susceptibility contrast perfusion and 11C-methionine positron emission tomography using different regions of interest.
Brendle C, Hempel JM, Schittenhelm J, Skardelly M, Reischl G, Bender B, Ernemann U, la Fougère C, Klose U
Neuroradiology. 2018 Apr;60(4):381-389.
PET/MRI Hybrid Systems.
Mannheim JG, Schmid AM, Schwenck J, Katiyar P, Herfert K, Pichler BJ, Disselhorst JA
Semin Nucl Med. 2018 Jul;48(4):332-347.
Oxygen-enhanced and dynamic contrast-enhanced optoacoustic tomography provide surrogate biomarkers of tumour vascular function, hypoxia and necrosis.
Tomaszewski MR, Gehrung M, Joseph J, Quiros Gonzalez I, Disselhorst JA, Bohndiek SE
Cancer Res. 2018 Oct 15;78(20):5980-5991.
Pre-clinical Imaging of Invasive Candidiasis Using ImmunoPET/MR.
Morad HOJ, Wild AM, Wiehr S, Davies G, Maurer A, Pichler BJ, Thornton CR
Front Microbiol. 2018 Aug 23;9:1996.
The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies.
Fruhwirth GO, Kneilling M, de Vries IJM, Weigelin B, Srinivas M, Aarntzen EHJG
Mol Imaging Biol. 2018 Oct;20(5):696-704.
Fast non-enhanced abdominal examination protocols in PET/MRI for patients with neuroendocrine tumors (NET): comparison to multiphase contrast-enhanced PET/CT.
Seith F, Schraml C, Reischl G, Nikolaou K, Pfannenberg C, la Fougère C, Schwenzer N
Radiol Med. 2018 Nov;123(11):860-870.
In vivo assessment of tumor heterogeneity in WHO 2016 glioma grades using diffusion kurtosis imaging: Diagnostic performance and improvement of feasibility in routine clinical practice.
Hempel JM, Schittenhelm J, Bisdas S, Brendle C, Bender B, Bier G, Skardelly M, Tabatabai G, Castaneda Vega S, Ernemann U, Klose U
J Neuroradiol. 2018 Feb;45(1):32-40.
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy.
Fransen MF, Schoonderwoerd M, Knopf P, Camps MG, Hawinkels LJ, Kneilling M, van Hall T, Ossendorp F
JCI Insight. 2018 Dec 6;3(23).
Effect of Perfusion on Diffusion Kurtosis Imaging Estimates for In Vivo Assessment of Integrated 2016 WHO Glioma Grades : A Cross-Sectional Observational Study.
Hempel JM, Schittenhelm J, Brendle C, Bender B, Bier G, Skardelly M, Tabatabai G, Castaneda Vega S, Ernemann U, Klose U
Clin Neuroradiol. 2018 Dec;28(4):481-491.
Comparison of 68Ga-labelled PSMA-11 and 11C-choline in the detection of prostate cancer metastases by PET/CT.
Schwenck J, Rempp H, Reischl G, Kruck S, Stenzl A, Nikolaou K, Pfannenberg C, la Fougère C
Eur J Nucl Med Mol Imaging. 2017 Jan;44(1):92-101
Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis.
Hermann D, Hirth N, Reimold M, Batra A, Smolka MN, Hoffmann S, Kiefer F, Noori HR, Sommer WH, Reischl G, la Fougère C, Mann K, Spanagel R, Hansson AC
Neuropsychopharmacology. 2017 Feb;42(3):606-614
[68Ga]NOTA-Galactosyl Human Serum Albumin: a Tracer for Liver Function Imaging with Improved Stability
Haubner R, Schmid AM, Maurer A, Rangger C, Roig LG, Pichler BJ, Virgolini IJ
Mol Imaging Biol. 2017 Oct;19(5):723-730.
In vivo hypoxia PET imaging quantifies the severity of arthritic joint inflammation in line with overexpression of HIF and enhanced ROS generation
Fuchs K, Kuehn A, Mahling M, Guenthoer P, Hector A, Hartl D, Laufer S, Kohlhofer U, Quintanilla-Martinez L, Reischl G, Röcken M, Pichler BJ, Kneilling M.
J Nucl Med. 2017 May;58(5):853-860.
β-[18F]Fluoro Azomycin Arabinoside (β-[18F]FAZA): Synthesis, radiofluorination and preliminary PET imaging of murine A431 tumors.
Kumar P, Roselt P, Reischl G, Cullinane C, Beiki D, Ehrlichmann W, Binns D, Naimi E, Yang J, Hicks R, Machulla HJ, Wiebe LI.
Curr Radiopharm. 2017;10(2):93-101.
In vivo molecular profiling of human glioma using diffusion kurtosis imaging.
Hempel JM, Bsidas S, Schlittenhelm J, Brendle C, Bender B, Wassmann H, Skardelly M, Tabatabai G, Vega SC, Ernemann U, Klose U.
J Neurooncol. Jan;131(1):93-101.
Spectral Clustering Predicts Tumor Tissue Heterogeneity Using Dynamic 18F-FDG PET: A Complement to the Standard Compartmental Modeling Approach
Katiyar P, Divine MR, Kohlhofer U, Quintanilla-Martinez L, Schölkopf B, Pichler BJ, Disselhorst JA.
J Nucl Med. Apr; 58(4):651-657.
Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients.
Simoncic U, Leibfarth S, Welz S, Schwenzer N, Schmidt H, Reischl G, Pfannenberg C, Fougère C, Nikolaou K, Zips D, Thorwarth D
Med Phys. 2017 Jun;44(6):2358-2368.
Influence of Co-57 and CT Transmission Measurements on the Quantification Accuracy and Partial Volume Effect of a Small Animal PET Scanner
Mannheim JG, Schmid AM, Pichler BJ.
Mol Imaging Biol. 2017 Dec;19(6):825-836.
Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.
Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.
Nat Med. May;23(5):601-610
A Novel Unsupervised Segmentation Approach Quantifies Tumor Tissue Populations Using Multiparametric MRI: First Results with Histological Validation.
Katiyar P, Divine MR, Kohlhofer U, Quintanilla-Martinez L, Schölkopf B, Pichler BJ, Disselhorst JA
Mol Imaging Biol. Jun;19(3):391-397
Characterization of a Novel Murine Model for Spontaneous Hemorrhagic Stroke using in vivo PET and MR multiparametric imaging.
Vega SC, Weinl C, Calaminus C, Wang L, Harant M, Ehrlichmann W, Thiele D, Kohlhofer U, Reischl G, Hempel JM, Ernemann U, Quintanilla Martinez L, Nordheim A, Pichler BJ
Neuroimage. 2017 Jul 15;155:245-256.
Prognostic value of dynamic hypoxia PET in head and neck cancer: Results from a planned interim analysis of a randomized phase II hypoxia-image guided dose escalation trial.
Welz S, Mönnich D, Pfannenberg C, Nikolaou K, Reimold M, La Fougère C, Reischl G, Mauz PS, Paulsen F, Alber M, Belka C, Zips D, Thorwarth D
Radiother Oncol. 2017 Sep;124(3):526-532.
Do all roads lead to Rome? A comparison of brain networks derived from inter-subject volumetric and metabolic covariance and moment-to-moment hemodynamic correlations in old individuals.
Di X, Gohel S, Thielcke A, Wehrl HF, Biswal BB
Brain Struct Funct. 2017 Nov;222(8):3833-3845.
Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT.
Hoffmann SHL, Maurer A, Reck DI, Reischl G, Pichler BJ, Kneilling M, Griessinger CM
J Vis Exp. Apr 29;(122)
Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent.
Schwenck J, Maier FC, Kneilling M, Wiehr S, Fuchs K
J Vis Exp. May 8;(123)
Overlap of highly FDG-avid and FMISO hypoxic tumor subvolumes in patients with head and neck cancer.
Mönnich D, Thorwarth D, Leibfarth S, Pfannenberg C, Reischl G, Mauz PS, Nikolaou K, la Fougère C, Zips D, Welz S
Acta Oncol. 2017 Nov;56(11):1577-1582.
Validity of longitudinal sections for determining the apical constriction.
Schell S, Judenhofer MS, Mannheim JG, Hülber-J M, Löst C, Pichler BJ, ElAyouti A
Int Endod J. Jul;50(7):706-712
Imaging neuronal pathways with 52Mn PET: Toxicity evaluation in rats.
Napieczynska H, Severin GW, Fonslet J, Wiehr S, Menegakis A, Pichler BJ, Calaminus C
Neuroimage. Jun 30;158:112-125
Gender differences in cerebral metabolism for color processing in mice: A PET/MRI Study.
Njemanze PC, Kranz M, Amend M, Hauser J, Wehrl H, Brust P
PLoS One. 2017 Jul 19;12(7):e0179919.
A novel optically transparent RF shielding for fully integrated PET/MRI systems.
Parl C, Kolb A, Schmid AM, Wehrl HF, Disselhorst JA, Soubiran PD, Stricker-Shaver D, Pichler BJ.
Phys Med Biol. Sep 1;62(18):7357-7378.
Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography.
Thunemann M, Schörg BF, Feil S, Lin Y, Voelkl J, Golla M, Vachaviolos A, Kohlhofer U, Quintanilla-Martinez L, Olbrich M, Ehrlichmann W, Reischl G, Griessinger CM, Langer HF, Gawaz M, Lang F, Schäfers M, Kneilling M, Pichler BJ, Feil R
Nat Commun. Sep 5;8(1):444
Geometric analysis of loco-regional recurrences in relation to pre-treatment hypoxia in patients with head and neck cancer
Boeke S, Thorwarth D, Mönnich D, Pfannenberg C, Reischl G, La Fougère C, Nikolaou K, Mauz PS, Paulsen F, Zips D, Welz S
Acta Oncol. 2017 Nov;56(11):1571-1576.
SUV-quantification of physiological lung tissue in an integrated PET/MR-system: Impact of lung density and bone tissue.
Seith F, Schmidt H, Gatidis S, Bezrukov I, Schraml C, Pfannenberg C, la Fougère C, Nikolaou K, Schwenzer N
PLoS One. 2017 May 31;12(5):e0177856.
Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.
Davies G, Rolle AM, Maurer A, Spycher PR, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR
Theranostics. Aug 11;7(14):3398-3414
Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.
V Ungern-Sternberg SNI, Vogel S, Walker-Allgaier B, Geue S, Maurer A, Wild AM, Münzer P, Chatterjee M, Heinzmann D, Kremmer E, Borst O, Loughran P, Zernecke A, Neal MD, Billiar TR, Gawaz M, Seizer P
Thromb Haemost. 2017 Nov;117(11):2063-2078.
Histogram analysis of diffusion kurtosis imaging estimates for in vivo assessment of 2016 WHO glioma grades: A cross-sectional observational study.
Hempel JM, Schittenhelm J, Brendle C, Bender B, Bier G, Skardelly M, Tabatabai G, Castaneda Vega S, Ernemann U, Klose U
Eur J Radiol. 2017 Oct;95:202-211.
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.
Armento A, Ilina EI, Kaoma T, Muller A, Vallar L, Niclou SP, Krüger MA, Mittelbronn M, Naumann U
Int J Oncol. 2017 Aug;51(2):702-714.
Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice
Leibrock CB, Alesutan I, Voelkl J, Michael D, Castor T, Kohlhofer U, Quintanilla-Martinez L, Kübler L, Mannheim JG, Pichler BJ, Rosenblatt KP, Kuro-O M, Lang F.
J Mol Med (Berl). 2016 Jan;94(1):95-106.
Comprehensive Oncologic Imaging in Infants and Preschool Children With Substantially Reduced Radiation Exposure Using Combined Simultaneous 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging: A Direct Comparison to 18F-Fluor
Gatidis S, Schmidt H, Gücke B, Bezrukov I, Seitz G, Ebinger M, Reimold M, Pfannenberg CA, Nikolaou K, Schwenzer NF, Schäfer JF.
Invest Radiol. 2016 Jan;51(1):7-14.
[Simultaneous whole-body PET-MRI in pediatric oncology : More than just reducing radiation?].
Gatidis S, Gückel B, la Fougère C, Schmitt J, Schäfer JF.
Radiologe. 2016 Jul;56(7):622-30.
A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib.
Sinnberg T, Makino E, Krueger MA, Velic A, Macek B, Rothbauer U, Groll N6, Pötz O, Czemmel S, Niessner H, Meier F, Ikenberg K, Garbe C, Schittek B.
EBioMedicine. 2016 Jun;8:132-49.
A Population-Based Gaussian Mixture Model Incorporating 18F-FDG PET and Diffusion-Weighted MRI Quantifies Tumor Tissue Classes.
Divine MR, Katiyar P, Kohlhofer U, Quintanilla-Martinez L, Pichler BJ, Disselhorst JA
J Nucl Med. 2016 Mar;57(3):473-9.
Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tübingen, Germany.
Bailey DL, Pichler BJ, Gückel B, Barthel H, Beer AJ, Botnar R, Gillies R, Goh V, Gotthardt M, Hicks RJ, Lanzenberger R, la Fougere C, Lentschig M, Nekolla SG, Niederdraenk T, Nikolaou K, Nuyts J, Olego D, Riklund KÅ, Signore A, Schäfers M, Sossi V, et al.
Mol Imaging Biol. 2016 Oct;18(5):637-50.
Comparison of Positron Emission Tomography Quantification Using Magnetic Resonance- and Computed Tomography-Based Attenuation Correction in Physiological Tissues and Lesions: A Whole-Body Positron Emission Tomography/Magnetic Resonance Study in 66 Patient
Seith F, Gatidis S, Schmidt H, Bezrukov I, la Fougère C, Nikolaou K, Pfannenberg C, Schwenzer N.
Invest Radiol. 2016 Jan;51(1):66-71.
Comparison of small animal CT contrast agents
Mannheim JG, Schlichthaerle T, Kuebler L, Quintanilla-Martinez L, Kohlhofer U, Kneilling M, Pichler BJ
Contrast Media Mol Imaging. 2016 Jul;11(4):272-84.
Comparison of Tumor Uptake Heterogeneity Characterization Between Static and Parametric 18F-FDG PET Images in Non-Small Cell Lung Cancer
Tixier F, Vriens D, Cheze-Le Rest C, Hatt M, Disselhorst JA, Oyen WJ, de Geus-Oei LF, Visser EP, Visvikis D.
J Nucl Med. 2016 Jul;57(7):1033-9.
Correlation between positron emission tomography and Cerenkov luminescence imaging in vivo and ex vivo using 64Cu-labeled antibodies in a neuroblastoma mouse model.
Maier FC, Schmitt J, Maurer A, Ehrlichmann W, Reischl G, Nikolaou K, Handgretinger R, Pichler BJ, Thaiss WM.
Oncotarget. 2016 Oct 11;7(41):67403-67411
CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense.
Carevic M, Öz H, Fuchs K, Laval J, Schroth C, Frey N, Hector A, Bilich T, Haug M, Schmidt A, Autenrieth SE, Bucher K, Beer-Hammer S, Gaggar A, Kneilling M, Benarafa C, Gao JL, Murphy PM, Schwarz S, Moepps B, Hartl D.
J Innate Immun. 2016;8(4):362-73
Decoding intratumoral heterogeneity of breast cancer by multiparametric in vivo imaging: A translational study.
Schmitz J, Schwab J, Schwenck J, Chen Q, Quintanilla-Martinez L, Hahn M, Wietek B, Schwenzer N, Staebler A, Kohlhofer U, Aina OH, Hubbard NE, Reischl G, Borowsky AD, Brucker S, Nikolaou K, La Fougère C, Cardiff RD, Pichler BJ, Schmid AM
Cancer Res. 2016 Sep 15;76(18):5512-22.
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumor irradiationin murine xenograft models.
Eckert F, Schmitt J, Zips D, Krueger MA, Pichler BJ, Gillies SD, Strittmatter W, Handgretinger R, Schilbach K
Cancer Immunol Immunother. 2016 Aug;65(8):1003-13.
Fluorescence and Cerenkov luminescence imaging. Applications in small animal research.
Schwenck J, Fuchs K, Eilenberger SH, Rolle AM, Castaneda Vega S, Thaiss WM, Maier FC.
Nuklearmedizin. 2016;55(2):63-70.
ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo
Rolle AM, Hasenberg M, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M, Wiehr S.
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33
In Vivo Evaluation of [11C]DASB for Quantitative SERT Imaging in Rats and Mice
Walker M, Ehrlichmann W, Stahlschmidt A, Pichler B, Fischer K.
J Nucl Med. 2016 Jan;57(1):115-21.
Necrotic Cell Sensor Clec4e Promotes a Pro-Atherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response
Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z
Circulation. 2016 Oct 4;134(14):1039-1051
New pathogen-specific immunoPET/MR tracer for molecular imaging of a systemic bacterial infection
Wiehr S, Warnke P, Rolle AM, Schütz M, Oberhettinger P, Kohlhofer U, Quintanilla-Martinez L, Maurer A, Thornton C, Boschetti F, Reischl G, Autenrieth IB, Pichler BJ, Autenrieth SE
Oncotarget. 2016 Mar 8;7(10):10990-1001.
PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo.
Niessner H, Schmitz J, Tabatabai G, Schmid A, Calaminus C, Sinnberg T, Weide B, Eigentler TK, Garbe C, Schittek B, Quintanilla-Fend L, Bender B, Mai M, Praetorius C, Beissert S, Schackert G,..., Pichler BJ,...,Meier F
Clin Cancer Res. 2016 Dec 1;22(23):5818-5828
PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome.
Chen H; Fajol A; Hoene M; Zhang B; Schleicher ED; Lin Y; Calaminus C; Pichler BJ; Weigert C; Haring HU; Lang F; Foller, M
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5754-9.
Preclinical evaluation of the anti-tumor effects of the natural isoflavone genistein in two xenograft mouse models monitored by [18F]FDG, [18F]FLT, and [64Cu]NODAGA-cetuximab small animal PET.
Honndorf VS, Wiehr S, Rolle AM, Schmitt J, Kreft L, Quintanilla-Martinez L, Kohlhofer U, Reischl G, Maurer A, Boldt K, Schwarz M, Schmidt H, Pichler BJ
Oncotarget. 2016 May 10;7(19):28247-61.
The emerging role of myeloid-derived suppressor cells in lung diseases.
Kolahian S, Öz HH, Zhou B, Griessinger CM, Rieber N, Hartl D.
Eur Respir J. 2016 Mar;47(3):967-77.
The Synergistic Effect of Selumetinib/Docetaxel Combination Therapy Monitored by [(18)F]FDG/[(18)F]FLT PET and Diffusion-Weighted Magnetic Resonance Imaging in a Colorectal Tumor Xenograft Model.
Honndorf VS, Schmidt H, Wiehr S, Wehrl HF, Quintanilla-Martinez L, Stahlschmidt A, Barjat H, Emmas SA, Pichler BJ
Mol Imaging Biol. 2016 Apr;18(2):249-57.
The Positron Emission Tomography Tracer 3'-Deoxy-3'-[18F]Fluorothymidine ([18F]FLT) Is Not Suitable to Detect Tissue Proliferation Induced by Systemic Yersinia enterocolitica Infection in Mice
Wiehr S, Rolle AM, Warnke P, Kohlhofer U, Quintanilla-Martinez L, Reischl G, Autenrieth IB, Pichler BJ, Autenrieth SE
PLoS One. 2016 Oct 4;11(10):e0164163.
[18F]Fluoro-azomycin-2´-deoxy-β-d-ribofuranoside - A new imaging agent for tumor hypoxia in comparison with [18F]FAZA
Schweifer A, Maier F, Ehrlichmann W, Lamparter D, Kneilling M, Pichler BJ, Hammerschmidt F, Reischl G
Nucl Med Biol. 2016 Dec;43(12):759-769
Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease
Teo RT, Hong X, Yu-Taeger L, Huang Y, Tan LJ, Xie Y, To XV, Guo L, Rajendran R, Novati A, Calaminus C, Riess O, Hayden MR, Nguyen HP, Chuang KH, Pouladi MA
Hum Mol Genet. 2016 Jul 1;25(13):2621-2632
First protein and peptide characterization of the tarsal adhesive secretions in the desert locust, Schistocerca gregaria, and the Madagascar hissing cockroach, Gromphadorhina portentosa
Betz O, Maurer A, Verheyden AN, Schmitt C, Kowalik T, Braun J, Grunwald I, Hartwig A, Neuenfeldt M
2016 Oct;25(5):541-9
Symbiotic gut commensal bacteria act as host cathepsin S activity regulators
Steimle A, Gronbach K, Beifuss B, Schäfer A, Harmening R, Bender A, Maerz JK, Lange A, Michaelis L, Maurer A, Menz S, McCoy K, Autenrieth IB, Kalbacher H, Frick JS
J Autoimmun. 2016 Dec;75:82-95
Improved selectivity of mIBG uptake into neuroblastoma cells in vitro and in vivo by inhibition of organic cation transporter 3 uptake using clinically approved corticosteroids
Bayer M, Schmitt J, Dittmann H, Handgretinger R, Bruchelt G, Sauter AW
Nucl Med Biol. 2016 Sep;43(9):543-51
Combined PET/MR: A Technology Becomes Mature
Wehrl HF, Sauter AW, Divine MR, Pichler BJ.
J Nucl Med. 2015 Feb. 56(2):165-8.
The impact of weakly bound 89Zr on preclinical studies: Non-specific accumulation in solid tumors and aspergillus infection
Severin GW, Jørgensen JT, Wiehr S, Rolle AM, Hansen AE, Maurer A, Hasenberg M, Pichler B, Kjaer A, Jensen AI.
Nucl Med Biol. 2015 Apr;42(4):360-8.
Image-derived biomarkers and multimodal imaging strategies for lung cancer management
Sauter AW, Schwenzer N, Divine MR, Pichler BJ, Pfannenberg C.
Eur J Nucl Med Mol Imaging. 2015 Apr;42(4):634-43.
Evaluation of the Metabolic Activity of Echinococcus multilocularis in Rodents Using Positron Emission Tomography Tracers
Rolle AM, Soboslay PT, Reischl G, Hoffmann WH, Pichler BJ, Wiehr S.
Mol Imaging Biol. 2015 Aug;17(4):512-20.
64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET
Griessinger CM, Maurer A, Kesenheimer C, Kehlbach R, Reischl G, Ehrlichmann W, Bukala D, Harant M, Cay F, Brück J, Nordin R, Kohlhofer U, Rammensee HG, Quintanilla-Martinez L, Schaller M, Röcken M, Pichler BJ, Kneilling M.
Proc Natl Acad Sci U S A. 2015 Jan 27. 112(4):1161-6.
In vivo visualization of prostate-specific membrane antigen in glioblastoma
Schwenck J, Tabatabai G, Skardelly M, Reischl G, Beschorner R, Pichler B, la Fougère C.
Eur J Nucl Med Mol Imaging. 2015 Jan. 42(1):170-1.
Assessment of murine brain tissue shrinkage caused by different histological fixatives using magnetic resonance and computed tomography imaging
Wehrl HF, Bezrukov I, Wiehr S, Lehnhoff M, Fuchs K, Mannheim JG, Quintanilla-Martinez L, Kohlhofer U, Kneilling M, Pichler BJ, Sauter AW.
Histol Histopathol. 2015 May;30(5):601-13.
Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism
Umbach AT, Zhang B, Daniel C, Fajol A, Velic A, Hosseinzadeh Z, Bhavsar SK, Bock CT, Kandolf R, Pichler BJ, Amann KU, Föller M, Lang F.
Kidney Int. 2015 Apr;87(4):728-37.
Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism
Fahkri H, Zhang B, Fajol A, Hernando N, Elvira B, Mannheim JG, Pichler BJ, Daniel C, Amann K, Hirao A, Haight J, Mak TW, Lang F, Föller M.
Pflugers Arch. 2015 Sep;467(9):1871-80.
Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis
Cristofanon S, Abhari BA, Krueger M, Tchoghandjian A, Momma S, Calaminus C, Vucic D, Pichler BJ, Fulda S.
Cell Death Dis. 2015 Apr 16;6:e1724.
Regeneration of Degenerated Urinary Sphincter Muscles: Improved Stem Cell-Based Therapies and Novel Imaging Technologies
Amend B, Vaegler M, Fuchs K, Mannheim JG, Will S, Kramer U, Hart ML, Feitz W, Chapple C, Stenzl A, Aicher WK.
Cell Transplant. 2015;24(11):2171-83.
Inhibition of the PI3K pathway with buparlisib (BKM120) is a suitable strategy to overcome therapy resistance in melanoma-derived brain metastasis in vitro and in vivo
Niessner H, Schmitz J, Schmid A, Sinnberg T, Tabatabai G, Weide B, Garbe C, Quintanilla-Fend L, Beissert S, Kulms D, Pichler B, Meier F.
Exp Dermatol. 2015;24(3):E32.
Segmentation-based attenuation correction in positron emission tomography/magnetic resonance: erroneous tissue identification and its impact on positron emission tomography interpretation
Brendle C, Schmidt H, Oergel A, Bezrukov I, Mueller M, Schraml C, Pfannenberg C, la Fougère C, Nikolaou K, Schwenzer N.
Invest Radiol. 2015 May;50(5):339-46.
Quantitative Evaluation of Segmentation- and Atlas-Based Attenuation Correction for PET/MR on Pediatric Patients
Bezrukov I, Schmidt H, Gatidis S, Mantlik F, Schäfer JF, Schwenzer N, Pichler BJ.
J Nucl Med. 2015 Jul;56(7):1067-74.
Shine-Through in PET/MR Imaging: Effects of the Magnetic Field on Positron Range and Subsequent Image Artifacts
Kolb A, Sauter AW, Eriksson L, Vandenbrouke A, Liu CC, Levin C, Pichler BJ, Rafecas M.
J Nucl Med. 2015 Jun;56(6):951-4.
Quantification of β-Amyloidosis and rCBF with Dedicated PET, 7 T MR Imaging, and High-Resolution Microscopic MR Imaging at 16.4 T in APP23 Mice
Maier FC, Keller MD, Bukala D, Bender B, Mannheim JG, Brereton IM, Galloway GJ, Pichler BJ.
J Nucl Med. 2015 Oct;56(10):1593-9.
Combined PET/MR: The Real Work Has Just Started
Bailey DL, Antoch G, Bartenstein P, Barthel H, Beer AJ, Bisdas S, Bluemke DA, Boellaard R, Claussen CD, Franzius C, Hacker M, Hricak H, la Fougère C, Gückel B, Nekolla SG, Pichler BJ, Purz S, Quick HH, Sabri O, Sattler B, Schäfer J, Schmidt H, et al.
Mol Imaging Biol. 2015 Jun;17(3):297-312.
Combined PET/MRI: Multi-modality Multi-parametric Imaging Is Here
Bailey DL, Pichler BJ, Gückel B, Barthel H, Beer AJ, Bremerich J, Czernin J, Drzezga A, Franzius C, Goh V, Hartenbach M, Iida H, Kjaer A, la Fougère C, Ladefoged CN, Law I, Nikolaou K, Quick HH, Sabri O, Schäfer J, Schäfers M, Wehrl HF, Beyer T.
Mol Imaging Biol. 2015 Oct;17(5):595-608.
Combined unsupervised-supervised classification of multiparametric PET/MRI data: application to prostate cancer
Gatidis S, Scharpf M, Martirosian P, Bezrukov I, Küstner T, Hennenlotter J, Kruck S, Kaufmann S, Schraml C, la Fougère C, Schwenzer NF, Schmidt H.
NMR Biomed. 2015 Jul;28(7):914-22.
Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation. Oncoimmunology
Schilbach K, Alkhaled M, Welker C, Eckert F, Blank G, Ziegler H, Sterk M, Müller F, Sonntag K, Wieder T, Braumüller H, Schmitt J, Eyrich M, Schleicher S, Seitz C, Erbacher A, Pichler BJ, Müller H, Tighe R, Lim A, Gillies SD, Strittmatter W, et al.
Oncoimmunology. 2015 Mar 19;4(7):e1014760.
A Comparative pO2 Probe and [18F]-Fluoro-Azomycinarabino-Furanoside ([18F]FAZA) PET Study Reveals Anesthesia-Induced Impairment of Oxygenation and Perfusion in Tumor and Muscle
Mahling M, Fuchs K, Thaiss WM, Maier FC, Feger M, Bukala D, Harant M, Eichner M, Reutershan J, Lang F, Reischl G, Pichler BJ, Kneilling M.
PLoS One. 2015 Apr 22;10(4):e0124665.
Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat
Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP.
Brain. 2015 Dec;138(Pt 12):3632-53.
Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke
Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, Mauel S, Breithaupt A, Gruber AD, Wasylyk B, Olson EN, Adams RH, Pichler BJ, Nordheim A.
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9914-9.
Cholesterol Modification of p40-Specific Small Interfering RNA Enables Therapeutic Targeting of Dendritic Cells
Brück J, Pascolo S, Fuchs K, Kellerer C, Glocova I, Geisel J, Dengler K, Yazdi AS, Röcken M, Ghoreschi K.
J Immunol. 2015 Sep 1;195(5):2216-23.
A data driven method for estimation of Bavail and appKD using a single injection protocol with [11C]raclopride in the mouse
Wimberley CJ, Fischer K, Reilhac A, Pichler BJ, Gregoire MC.
Neuroimage. 2014 Oct. 99:365-76
Apical constriction: location and dimensions in molars-a micro-computed tomography study
ElAyouti A, Hülber-J M, Judenhofer MS, Connert T, Mannheim JG, Löst C, Pichler BJ, von Ohle C.
J Endod. 2014 Aug. 40(8):1095-9.
Implications of glycoprotein VI for theranostics
Gawaz M, Vogel S, Pfannenberg C, Pichler B, Langer H, Bigalke B.
Thromb Haemost. 2014 Jul 3;112(1):26-31.
In vivo optical imaging of matrix metalloproteinase activity detects acute and chronic contact hypersensitivity reactions and enables monitoring of the antiinflammatory effects of N-acetylcysteine
Schwenck J, Griessinger CM, Fuchs K, Bukala D, Bauer N, Eichner M, Röcken M, Pichler BJ, Kneilling M.
Mol Imaging. 2014;13.
In Vivo Tracking of Th1 Cells by PET Reveals Quantitative and Temporal Distribution and Specific Homing in Lymphatic Tissue
Griessinger CM, Kehlbach R, Bukala D, Wiehr S, Bantleon R, Cay F, Schmid A, Braumüller H, Fehrenbacher B, Schaller M, Eichner M, Sutcliffe JL, Ehrlichmann W, Eibl O, Reischl G, Cherry SR, Röcken M, Pichler BJ, Kneilling M.
J Nucl Med. 2014 Feb. 55(2):301-7
Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion
Maier FC, Wehrl HF, Schmid AM, Mannheim JG, Wiehr S, Lerdkrai C, Calaminus C, Stahlschmidt A, Ye L, Burnet M, Stiller D, Sabri O, Reischl G, Staufenbiel M, Garaschuk O, Jucker M, Pichler BJ.
Nat Med. 2014 Dec. 20(12):1485-92.
On the Quantification Accuracy, Homogeneity, and Stability of Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging Systems
Schmidt H, Schwenzer NF, Bezrukov I, Mantlik F, Kolb A, Kupferschläger J, Pichler BJ.
Invest Radiol. 2014 Jun. 49(6):373-81
PET/MR Imaging and Optical Imaging of Metastatic Rhabdomyosarcoma in Mice
Armeanu-Ebinger S, Griessinger CM, Herrmann D, Fuchs J, Kneilling M, Pichler BJ, Seitz G.
J Nucl Med. 2014 Sep. 55(9):1545-51
Pharmacokinetics and PET imaging properties of two recombinant anti-PSMA antibody fragments in comparison to their parental antibody
Wiehr S, Bühler P, Gierschner D, Wolf P, Rolle AM, Kesenheimer C, Pichler BJ, Elsässer-Beile U.
Prostate. 2014 May. 74(7):743-55
Preclinical and Translational PET/MR Imaging
Wehrl HF, Wiehr S, Divine MR, Gatidis S, Gullberg GT, Maier FC, Rolle AM, Schwenck J, Thaiss WM, Pichler BJ.
J Nucl Med. 2014 May 15. 55(Supplement 2):11S-18S.
Principles of PET/MR Imaging
Disselhorst JA, Bezrukov I, Kolb A, Parl C, Pichler BJ.
J Nucl Med. 2014 May 12. 55(Supplement 2):2S-10S.
Quantitative Correlation at the Molecular Level of Tumor Response to Docetaxel by Multimodal Diffusion-Weighted Magnetic Resonance Imaging and [18F]FDG/[18F]FLT Positron Emission Tomography
Honndorf VS, Schmidt H, Wehrl HF, Wiehr S, Ehrlichmann W, Quintanilla-Martinez L, Barjat H, Ricketts SA, Pichler BJ.
Mol Imaging. 2014 Nov 1. 13(0):1-12.
Radioimmunoimaging of liver metastases with PET using a 64Cu-labeled CEA antibody in transgenic mice
Nittka S, Krueger MA, Shively JE, Boll H, Brockmann MA, Doyon F, Pichler BJ, Neumaier M.
PLoS One. 2014 Sep 16. 9(9):e106921.
Simulation-based optimisation of the PET data processing for Partial Saturation Approach protocols
Wimberley C, Angelis G, Boisson F, Callaghan P, Fischer K, Pichler B, Meikle SR, Grégoire MC, Reilhac A.
Neuroimage. 2014 Aug 15. 97:29-40.
Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by Testosterone via Androgen Receptor Activation
Voelkl J, Pakladok T, Lin Y, Viereck R, Lebedeva A, Kukuk D, Pichler BJ, Alesutan I, Lang F.
Cell Physiol Biochem. 2014 Jun 27. 33(6):1911-1920.
Development of a novel depth of interaction PET detector using highly multiplexed G-APD cross-strip encoding
Kolb A, Parl C, Mantlik F, Liu CC, Lorenz E, Renker D, Pichler BJ.
Med Phys. 2014 Aug. 41(8):081916.
Evaluation of positron emission tomographic tracers for imaging of papillomavirus-induced tumors in rabbits
Probst S, Wiehr S, Mantlik F, Schmidt H, Kolb A, Münch P, Delcuratolo M, Stubenrauch F, Pichler BJ, Iftner T.
Mol Imaging. 2014 Jan-Feb. 13(1).
Assessment of rodent brain activity using combined [15O]H2O-PET and BOLD-fMRI
Wehrl HF, Martirosian P, Schick F, Reischl G, Pichler BJ.
Neuroimage. 2014 Apr 1. 89:271-9
Combined PET/MR: Where Are We Now? Summary Report of the Second International Workshop on PET/MR Imaging April 8-12, 2013, Tubingen, Germany
Bailey DL, Barthel H, Beuthin-Baumann B, Beyer T, Bisdas S, Boellaard R, Czernin J, Drzezga A, Ernemann U, Franzius C, Gückel B, Handgretinger R, Hartenbach M, Hellwig D, Nadel H, Nekolla SG, Pfluger T, Pichler BJ, Quick HH, Sabri O, Sattler B, et al.
Mol Imaging Biol. 2014 Jun. 16(3):295-310.
A novel transgenic rat model for spinocerebellar ataxia type 17 recapitulates neuropathological changes and supplies in vivo imaging biomarkers
Kelp A, Koeppen AH, Petrasch-Parwez E, Calaminus C, Bauer C, Portal E, Yu-Taeger L, Pichler B, Bauer P, Riess O, Nguyen HP.
J Neurosci. 2013 May 22. 33(21):9068-81.
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O
Brain 2013 136(2): 412-432
Feasibility of Sequential PET/MRI Using a State-of-the-Art Small Animal PET and a 1 T Benchtop MRI
Schmid A, Schmitz J, Mannheim JG, Maier FC, Fuchs K, Wehrl HF, Pichler BJ
Mol Imaging Biol. 2013 Apr. 15(2):155-65.
Imaging Findings and Therapy Response Monitoring in Chronic Sclerodermatous Graft-Versus-Host Disease: Preliminary Data of a Simultaneous PET/MRI Approach
Sauter AW, Schmidt H, Mantlik F, Kolb A, Federmann B, Pfannenberg C, Reimold M, Pichler BJ, Bethge W, Horger MS.
Clin Nucl Med. 2013 Aug. 38(8):e309-17
Impact of Anesthetics On 3'-[18F]Fluoro-3'-Deoxythymidine ([18F]FLT) Uptake in Animal Models of Cancer and Inflammation
Fuchs K, Kukuk D, Mahling M, Quintanilla-Martinez L, Reischl G, Reutershan J, Lang F, Röcken M, Pichler BJ, Kneilling M.
Mol Imaging. 2013 Aug 1. 12(5):277-87.
In Vivo Imaging of Cell Proliferation Enables the Detection of the Extent of Experimental Rheumatoid Arthritis by 3'-Deoxy-3'-18F-Fluorothymidine and Small-Animal PET
Fuchs K, Kohlhofer U, Quintanilla-Martinez L, Lamparter D, Kötter I, Reischl G, Röcken M, Pichler BJ, Kneilling M.
J Nucl Med. 2013 Jan. 54(1):151-8
MR-Based Attenuation Correction Methods for Improved PET Quantification in Lesions Within Bone and Susceptibility Artifact Regions
Bezrukov I, Schmidt H, Mantlik F, Schwenzer N, Brendle C, Schölkopf B, Pichler BJ.
J Nucl Med. 2013 Oct. 54(10):1768-74
MR-Based PET Attenuation Correction for PET/MR Imaging
Bezrukov I, Mantlik F, Schmidt H, Schölkopf B, Pichler BJ.
Semin Nucl Med. 2013 Jan. 43(1):45-59.
Multimodal Elucidation of Choline Metabolism in a Murine Glioma Model using Magnetic Resonance Spectroscopy and 11C-choline Positron Emission Tomography
Wehrl HF, Schwab J, Hasenbach K, Reischl G, Tabatabai G, Quintanilla-Martinez L, Jiru F, Chughtai K, Kiss A, Cay F, Bukala D, Heeren RM, Pichler BJ, Sauter AW.
Cancer Res. 2013 Mar 1. 73(5):1470-80.
Non-invasive Monitoring of Pancreatic Tumor Progression in the RIP1-Tag2 Mouse by Magnetic Resonance Imaging
Schmid A, Braumüller H, Wehrl HF, Röcken M, Pichler BJ
Mol Imaging Biol. 2013 Apr. 15(2):186-93.
Preclinical Evaluation of a Novel c-Met Inhibitor in a Gastric Cancer Xenograft Model Using Small Animal PET
Wiehr S, von Ahsen O, Röse L, Mueller A, Mannheim JG, Honndorf V, Kukuk D, Reischl G, Pichler BJ.
Mol Imaging Biol. 2013 Apr. 15(2):203-11.
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen
Singh Y, Braeuning A, Schmid A, Pichler BJ, Schwarz M.
Arch Toxicol. 2013 Aug. 87(8):1595-607
Simultaneous PET/MR reveals Brain Function in Activated and Resting State on Metabolic, Hemodynamic and Multiple Temporal Scales
Wehrl HF, Hossain M, Lankes K, Liu C-C, Bezrukov I, Martirosian P, Schick F, Reischl G, Pichler BJ.
Nat. Med. 2013 Sep. 19(9): 1184-9
SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
Bareiss PM, Paczulla A, Wang H, Schairer R, Wiehr S, Kohlhofer U, Rothfuss OC, Fischer A, Perner S, Staebler A, Wallwiener D, Fend F, Fehm T, Pichler B, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C.
Cancer Res. 2013 Sep 1. 73(17):5544-55
Summary Report of the First International Workshop on PET/MR Imaging, March 19-23, 2012, Tübingen, Germany
Bailey DL, Barthel H, Beyer T, Boellaard R, Gückel B, Hellwig D, Herzog H, Pichler BJ, Quick HH, Sabri O, Scheffler K, Schlemmer HP, Schwenzer NF, Wehrl HF.
Mol Imaging Biol. 2013 Aug. 15(4):361-71
6-Hydroxydopamine leads to T2 hyperintensity, decreased claudin-3 immunoreactivity and altered aquaporin 4 expression in the striatum
Wachter B, Schürger S, Schmid A, Gröger A, Sadler R, Speidel A, Rolinger J, Pichler BJ, Berg D, Wagner HJ, von Ameln-Mayerhofer A, Küppers E.
Behav Brain Res. 2012 Jun 15;232(1):148-58.
A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington Disease
Yu-Taeger L, Petrasch-Parwez E, Osmand AP, Redensek A, Metzger S, Clemens LE, Park L, Howland D, Calaminus C, Gu X, Pichler B, Yang XW, Riess O, Nguyen HP
J Neurosci. 2012 Oct 31;32(44):15426-38.
An Evaluation of 2-deoxy-2-[(18)F]Fluoro-D-Glucose and 3'-deoxy-3'-[(18)F]-Fluorothymidine Uptake in Human Tumor Xenograft Models
H. Keen, B. Pichler, D. Kukuk, O. Duchamp, O. Raguin, A. Shannon, N. Whalley, V. Jacobs, J. Bales, N. Gingles, S.A. Ricketts, S.R. Wedge
Mol Imaging Biol. 2012 Jun;14(3):355-65.
Enhanced FGF23 Serum Concentrations and Phosphaturia in Gene Targeted Mice Expressing WNK-Resistant Spak
Pathare G, Föller M, Michael D, Walker B, Hierlmeier M, Mannheim JG, Pichler BJ, Lang F
Kidney Blood Press Res. 2012;36(1):355-64.
Ex vivo imaging of injured arteries in rabbits using fluorescence-labelled glycoprotein VI-Fc
B. Bigalke, S. Lindemann, T. Schönberger, I. Pohlmeyer, A. Chiribiri, A. Schuster, R.M. Botnar, C.M. Griessinger, B.J. Pichler, M. Gawaz
Platelets. 2012;23(1):1-6.
Generation of a novel rodent model for DYT1 dystonia
Grundmann K, Glöckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, Pisani A, Riess O, Ott T.
Neurobiol Dis. 2012 Jul;47(1):61-74.
Imaging DA release in a rat model of L-DOPA-induced dyskinesias: A longitudinal in vivo PET investigation of the antidyskinetic effect of MDMA
Lettfuss NY, Fischer K, Sossi V, Pichler BJ, von Ameln-Mayerhofer A
Neuroimage. 2012 Oct 15;63(1):423-33.
In vivo quantification of dopamine transporters in mice with unilateral 6-OHDA lesions using [(11)C]methylphenidate and PET
K. Fischer, V. Sossi, A. von Ameln-Mayerhofer, G. Reischl, B.J. Pichler
Neuroimage. 2012 Feb 1;59(3):2413-22.
Monitoring the glioma tropism of bone marrow-derived progenitor cells by 2-photon laser scanning microscopy and positron emission tomography
K. Hasenbach, S. Wiehr, C. Herrmann, J. Mannheim, F. Cay, G. von Kürthy, T. Bolmont, S.A. Grathwohl, M. Weller, C. Lengerke, B.J. Pichler, G. Tabatabai
Neuro Oncol. 2012 Apr;14(4):471-81.
Oxygen Breathing Affects 3'-Deoxy-3'-18F-Fluorothymidine Uptake in Mouse Models of Arthritis and Cancer
Fuchs K, Kukuk D, Reischl G, Föller M, Eichner M, Reutershan J, Lang F, Röcken M, Pichler BJ, Kneilling M.
J Nucl Med. 2012 May;53(5):823-30.
Quantification accuracy and partial volume effect in dependence of the attenuation correction of a state-of-the-art small animal PET scanner
Mannheim JG, Judenhofer MS, Schmid A, Tillmanns J, Stiller D, Sossi V, Pichler BJ
Phys Med Biol. 2012 Jun 21;57(12):3981-93.
Quantitative Analysis of the Growth Kinetics of Chemically-Induced Mouse Liver Tumors by Magnetic Resonance Imaging
A. Schmid, B. Rignall, B.J. Pichler, M. Schwarz
Toxicol Sci. 2012 Mar;126(1):52-9.
Sgk1 sensitivity of Na(+)/H (+) exchanger activity and cardiac remodeling following pressure overload
J. Voelkl, Y. Lin, I. Alesutan,M.S. Ahmed, V. Pasham, S. Mia, S. Gu, M. Feger, A. Saxena, B. Metzler, D. Kuhl, B.J. Pichler, F. Lang
Basic Res Cardiol. 2012 Mar;107(2):236.
Simultaneous PET/MR imaging of the brain: feasibility of cerebral blood flow measurements with FAIR-TrueFISP arterial spin labeling MRI
Stegger L, Martirosian P, Schwenzer N, Bisdas S, Kolb A, Pfannenberg C, Claussen CD, Pichler B, Schick F, Boss A
Acta Radiol. 2012 Nov 1;53(9):1066-72.
Technical performance evaluation of a human brain PET/MRI system
Kolb A, Wehrl HF, Hofmann M, Judenhofer MS, Eriksson L, Ladebeck R, Lichy MP, Byars L, Michel C, Schlemmer HP, Schmand M, Claussen CD, Sossi V, Pichler BJ
Eur Radiol. 2012 Aug;22(8):1776-88.
Unfavorable consequences of chronic cardiac HIF-1α stabilization
M. Hölscher, K. Schäfer, S. Krull, K. Farhat, A. Hesse, M. Silter, Y. Lin, B.J. Pichler, P. Thistlethwaite, A. El Armouche, L.S. Maier, D.M. Katschinski, A. Zieseniss
Cardiovasc Res. 2012 Apr 1;94(1):77-86.
[(68)Ga]NODAGA-RGD for imaging α(v)β (3) integrin expression
P.A. Knetsch, M. Petrik, C.M. Griessinger, C. Rangger, M. Fani, C. Kesenheimer, E. von Guggenberg, B.J. Pichler, I. Virgolini, C. Decristoforo, R. Haubner
Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1303-12.
Assessment of MR compatibility of a PET insert developed for simultaneous multiparametric PET/MR imaging on an animal system operating at 7 T
H.F. Wehrl, M.S. Judenhofer, A. Thielscher, P. Martirosian, F. Schick, B.J. Pichler
Magn Reson Med. 2011 Jan;65(1):269-79.
Assessment of PET Tracer Uptake in Hormone-Independent and Hormone-Dependent Xenograft Prostate Cancer Mouse Models
D. Kukuk, G. Reischl, O. Raguin, S. Wiehr, M.S. Judenhofer, C. Calaminus, V.S. Honndorf, L. Quintanilla-Martinez, T. Schönberger, O. Duchamp, H.J. Machulla, B.J. Pichler
J Nucl Med. 2011 Oct;52(10):1654-63.
Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3
M. Bhandaru, D.S. Kempe, A. Rotte, P. Capuano, G. Pathare, M. Sopjani, I. Alesutan, L. Tyan, D.Y. Huang, B. Siraskar, M.S. Judenhofer, G. Stange, B.J. Pichler, J. Biber, L. Quintanilla-Martinez, C.A. Wagner, D. Pearce, M. Föller, F. Lang
Kidney Int. 2011 Jul;80(1):61-7.
Feasibility of simultaneous PET/MR imaging in the head and upper neck area
A. Boss, L. Stegger, S. Bisdas, A. Kolb, N. Schwenzer, M. Pfister, C.D. Claussen, B.J. Pichler, C. Pfannenberg
Eur Radiol. 2011 Jul;21(7):1439-46.
Imaging of injured and atherosclerotic arteries in mice using fluorescence-labeled glycoprotein VI-Fc
B. Bigalke, I. Pohlmeyer, T. Schönberger, C.M. Griessinger, M. Ungerer, R.M. Botnar, B.J. Pichler, M. Gawaz
Eur J Radiol. 2011 Aug;79(2):e63-9.
Letter to the editor re: molecular imaging in oncology: the acceptance of PET/CT and the emergence of MR/PET imaging
A. Sauter, A. Kolb, M. Soekler, M. Reimold, N. Schwenzer, C. Pfannenberg, C. Claussen, B. Pichler, M. Horger
Eur Radiol. 2011 Aug;21(8):1709-12.
MRI-Based Attenuation Correction for Whole-Body PET/MRI: Quantitative Evaluation of Segmentation- and Atlas-Based Methods
M. Hofmann, I. Bezrukov, F. Mantlik, P. Aschoff, F. Steinke, T. Beyer, B.J. Pichler, B. Schölkopf
J Nucl Med. 2011 Sep;52(9):1392-9.
Noninvasive nuclear imaging enables the in vivo quantification of striatal dopamine receptor expression and raclopride affinity in mice
K. Fischer, V. Sossi, A. Schmid, M. Thunemann, F.C. Maier, M.S. Judenhofer, J.G. Mannheim, G. Reischl, B.J. Pichler
J Nucl Med. 2011 Jul;52(7):1133-41.
PKB/SGK-Resistant GSK3 Enhances Phosphaturia and Calciuria
M. Föller, D.S. Kempe, K.M. Boini, G. Pathare, B. Siraskar, P. Capuano, I. Alesutan, M. Sopjani, G. Stange, N. Mohebbi, M. Bhandaru, T.F. Ackermann, M.S. Judenhofer, B.J. Pichler, J. Biber, C.A. Wagner, F. Lang
J Am Soc Nephrol. 2011 May;22(5):873-80.
Simultaneous (68)Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience
D. Thorwarth, G. Henke, A.C. Müller, M. Reimold, T. Beyer, A. Boss, A. Kolb, B. Pichler, C. Pfannenberg
Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):277-83.
The effect of patient positioning aids on PET quantification in PET/MR imaging
F. Mantlik, M. Hofmann, M.K. Werner, A. Sauter, J. Kupferschläger, B. Schölkopf, B.J. Pichler, T. Beyer
Eur J Nucl Med Mol Imaging. 2011 May;38(5):920-9.
Akt2/PKBbeta-sensitive regulation of renal phosphate transport
D.S. Kempe, T.F. Ackermann, K.M. Boini, F. Klaus, A.T. Umbach, M. Dërmaku-Sopjani, M.S. Judenhofer, B.J. Pichler, P. Capuano, G. Stange, C.A. Wagner, M.J. Birnbaum, D. Pearce, M. Föller, F. Lang
Acta Physiol (Oxf). 2010 Sep;200(1):75-85.
Combined PET/MR Imaging - Technology and Applications
H. F. Wehrl, A. W. Sauter, M. S. Judenhofer, B.J. Pichler
Technol Cancer Res Treat. 2010 Feb;9(1):5-20.
Combined PET/MRI: one step further in multimodality imaging
A.W. Sauter, H.F. Wehrl, A. Kolb, M.S. Judenhofer, B.J. Pichler
Trends Mol Med. 2010 Nov;16(11):508-15.
Diffusion tensor imaging in a human PET/MR hybrid system
A. Boss, A. Kolb, M. Hofmann, S. Bisdas, T. Nägele, U. Ernemann, L. Stegger, C. Rossi, H.P. Schlemmer, C. Pfannenberg, M. Reimold, C.D. Claussen, B.J. Pichler, U. Klose
Invest Radiol. 2010 May;45(5):270-4.
Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite
C. Hübner, S. Wiehr, L. Kocherscheidt, H. Wehrl, B.J. Pichler, A. Schmid, P. Kern, P.T. Soboslay
Parasitol Res. 2010 Jul;107(2):459-63.
Evaluation of Geiger-mode APDs for PET block detector designs
A. Kolb, E. Lorenz, M.S. Judenhofer, D. Renker, K. Lankes, B.J. Pichler
Phys Med Biol. 2010 Apr 7;55(7):1815-32.
High-resolution animal PET imaging of prostate cancer xenografts with three different (64)Cu-labeled antibodies against native cell-adherent PSMA
K. Alt, S. Wiehr, W. Ehrlichmann, G. Reischl, P. Wolf, B.J. Pichler, U. Elsässer-Beile, P. Bühler
Prostate. 2010 Sep 15;70(13):1413-21.
Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT
A. Boss, S. Bisdas, A. Kolb, M. Hofmann, U. Ernemann, C.D. Claussen, C. Pfannenberg, B.J. Pichler, M. Reimold, L. Stegger
J Nucl Med. 2010 Aug;51(8):1198-205.
Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI
K. Büscher, M.S. Judenhofer, M.T. Kuhlmann, S. Hermann, H.F. Wehrl, K.P. Schäfers, M. Schäfers, B.J. Pichler, L. Stegger
J Nucl Med. 2010 Aug;51(8):1277-84.
Para-phenylenediamine-specific lymphocyte activation test: a sensitive in vitro assay to detect para-phenylenediamine sensitization in patients with severe allergic reactions
M. Kneilling, U. Caroli, C. Grimmel, J. Fischer, M. Eichner, T. Wieder, F.C. Maier, M. Röcken, T. Biedermann
Exp Dermatol. 2010 May;19(5):435-41.
PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications
B.J. Pichler, A. Kolb, T. Nägele, H.P Schlemmer
J Nucl Med. 2010 Mar;51(3):333-6.
Phosphoglycerate kinase 1 promoting tumor progression and metastasis in gastric cancer - detected in a tumor mouse model using positron emission tomography/magnetic resonance imaging
D. Zieker, I. Königsrainer, J. Weinreich, S. Beckert, J. Glatzle, K. Nieselt, S. Bühler, M. Löffler, J. Gaedcke, H. Northoff, J.G. Mannheim, S. Wiehr, B.J. Pichler, C. von Weyhern, B.L. Brücher, A. Königsrainer
Cell Physiol Biochem. 2010;26(2):147-54.
Switching on the Lights for Real-Time Multimodality Tumor Neuroimaging: The Integrated Positron-Emission Tomography/MR Imaging System
S. Bisdas, T. Nägele, H.P. Schlemmer, A. Boss, C.D. Claussen, B. Pichler, U. Ernemann
AJNR Am J Neuroradiol. 2010 Apr;31(4):610-4.
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
S. Nuber, T. Franck, H. Wolburg, U. Schumann, N. Casadei, K. Fischer, C. Calaminus, B.J. Pichler, S. Chanarat, P. Teismann, J.B. Schulz, A.R. Luft, J. Tomiuk, J. Wilbertz, A. Bornemann, R. Krüger, O. Riess
Neurogenetics. 2010 Feb;11(1):107-20.
A decade of combined imaging: from a PET attached to a CT to a PET inside an MR
T. Beyer, B.J. Pichler
Eur J Nucl Med Mol Imaging. 2009 Mar;36 Suppl 1:S1-2.
Direct Crosstalk between Mast Cell-TNF and TNFR1-expressing Endothelia Mediates Local Tissue Inflammation
M. Kneilling , R. Mailhammer, L. Hültner, T. Schönberger, K. Fuchs, M. Schaller, D. Bukala, S. Massberg, C.A. Sander, M. Eichner, K.L. Maier, R. Hallmann, B.J. Pichler, R. Haubner, M. Gawaz, K. Pfeffer, T. Biedermann, M. Röcken
Blood. 2009 Aug 20;114(8):1696-706.
Molecular Imaging
H.P Schlemmer, R. Bares, C.D. Claussen, B.J. Pichler
Dtsch Med Wochenschr. 2009 May;134(19):1000-5.
New perspectives on bone marrow contrast agents and molecular imaging
H.E. Daldrup-Link, A. Mohanty, C. Cuenod, B. Pichler, T. Link
Semin Musculoskelet Radiol. 2009 Jun;13(2):145-56.
PET imaging of prostate cancer xenografts with a highly specific antibody against the postate specific membrane antigen
U. Elsässer-Beile, G. Reischl. S. Wiehr, P. Bühler, P. Wolf, K. Alt, J. Shively, M.S. Judenhofer, H.J. Machulla, B.J. Pichler
J Nucl Med. 2009 Apr;50(4):606-11.
Pre-clinical PET/MR: technological advances and new perspectives in biomedical research
H.F. Wehrl, M.S. Judenhofer, S. Wiehr, B.J. Pichler
Eur J Nucl Med Mol Imaging. 2009 Mar;36 Suppl 1:S56-68.
Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques
M. Hofmann, B.J. Pichler, B. Schölkopf, T. Beyer
Eur J Nucl Med Mol Imaging. 2009 Mar;36 Suppl 1:S93-104.
An integrated MR/PET system: prospective applications
H-P.W. Schlemmer, B.J. Pichler, R. Krieg, W.D. Heiss
Abdom Imaging. 2009 Nov;34(6):668-74.
Anemia and splenomegaly in cGKI-deficient mice
M. Föller, S. Feil, K. Ghoreschi, S. Koka, A. Gerling, M. Thunemann, F. Hofmann, B. Schuler, J. Vogel, B. Pichler, R.S. Kasinathan, J.P. Nicolay, S.M. Huber, F. Lang, R. Feil
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6771-6.
Cell tracking with optical imaging
E.J. Sutton, T.D. Henning, B.J. Pichler, C. Bremer, H.E. Daldrup-Link
Eur Radiol. 2008 Oct;18(10):2021-32.
Latest advances in molecular imaging instrumentation
B.J. Pichler, H.F. Wehrl, M.S. Judenhofer
J Nucl Med. 2008 Jun;49 Suppl 2:5S-23S.
Measurement of T1, T2, and Magnetization Transfer Properties During Embryonic Development at 7 Tesla Using the Chicken Model
A. Boss, M. Oppitz, H.F. Wehrl, C. Rossi, M. Feuerstein, C.D. Claussen, U. Drews, B.J. Pichler, F.Schick
J Magn Reson Imaging. 2008 Dec;28(6):1510-4.
MRI-Based Attenuation Correction for PET/MRI: A Novel Approach Combining Pattern Recognition and Atlas Registration
M. Hofmann, F. Steinke, V. Scheel, G. Charpiat, J. Farquhar, P. Aschoff, M. Brady, B. Schölkopf, B.J. Pichler
J Nucl Med. 2008 Nov;49(11):1875-83.
Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease
Nuber S, Petrasch-Parwez E, Winner B, Winkler J, von Hoersten S, Schmidt T, Boy J, Kuhn M, Nguyen HP, Teismann P, Schulz JB, Neumann M, Pichler BJ, Reischl G, Holzmann C, Schmitt I, Bornemann A, Kuhn W, Zimmermann F, Servadio A, Riess O.
J Neurosci. 2008 Mar 5;28(10):2471-84.
PET/MRI hybrid imaging: devices and initial results
B.J. Pichler, M.S. Judenhofer, H.F. Wehrl
Eur Radiol. 2008 Jun;18(6):1077-86.
Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo
C. Schulz, S. Penz, C. Hoffmann, H. Langer, A. Gillitzer, S. Schneider, R. Brandl, S. Seidl, S. Massberg, B. Pichler, E. Kremmer, K. Stellos, T. Schönberger, W. Siess, M. Gawaz
Basic Res Cardiol. 2008 Jul;103(4):356-67.
Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging?
B.J. Pichler, H.F. Wehrl, A. Kolb, M.S. Judenhofer
Semin Nucl Med. 2008 May;38(3):199-208.
Radionuclide imaging: A molecular key to the atherosclerotic plaque
H.F. Langer, R. Haubner, B.J. Pichler, M. Gawaz
J Am Coll Cardiol. 2008 Jul 1;52(1):1-12.
Simultaneous in vivo positron emission tomography and magnetic resonance imaging
Catana C, Procissi D, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Jacobs RE, Cherry SR.
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3705-10.
Simultaneous MR/PET Imaging of the Human Brain: Feasibility Study
H-P.W. Schlemmer, B.J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P.K. Jacob, W.-D. Heiss, C.D. Claussen
Radiology. 2008 Sep;248(3):1028-35.
Simultaneous PET/MRI: A new approach for functional and morphological imaging
M.S. Judenhofer, H.F. Wehrl, D.F. Newport, C. Catana, S.B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Röcken, R.E. Nutt, H.-J. Machulla, K. Uludag, S.R. Cherry, C.D. Claussen, B.J. Pichler
Nat Med. 2008 Apr;14(4):459-65.
Single and dual energy attenuation correction in PET/CT in the presence of iodine based contrast agents
N.S. Rehfeld, B.J. Heismann, J. Kupferschläger, P. Aschoff, G. Christ, A.C. Pfannenberg, B.J. Pichler
Med Phys. 2008 May;35(5):1959-69.
T cell-mediated help against tumors
T. Wieder, H. Braumüller, M. Kneilling, B. Pichler, M. Röcken
Cell Cycle. 2008 Oct;7(19):2974-7.
The immunoadhesin glycoprotein VI-Fc regulates arterial remodeling after mechanical injury in ApoE-/- mice
T. Schönberger, D. Siegel&ndash. Axel, R. Buß. l, S. Richter, M.S. Judenhofer, R. Haubner, G. Reischl, K. Klingel, G. Münch, P. Seizer, B.J. Pichler, M. Gawaz
Cardiovasc Res. 2008 Oct 1;80(1):131-7.
TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis
N. Müller-Hermelink, H. Braumüller, B. Pichler, T. Wieder, R. Mailhammer, K. Schaak, K. Ghoreschi, A. Yazdi, R. Haubner, C.A. Sander, R. Mocikat, M. Schwaiger, I. Förster, R. Huss, W.A. Weber, M. Kneilling, M. Röcken
Cancer Cell. 2008 Jun;13(6):507-18.
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy
Alavi MV, Bette S, Schimpf S, Schuettauf F, Schraermeyer U, Wehrl HF, Ruttiger L, Beck SC, Tonagel F, Pichler BJ, Knipper M, Peters T, Laufs J, Wissinger B.
Brain. 2007 Apr;130(Pt 4):1029-42.
PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet
Judenhofer MS, Catana C, Swann BK, Siegel SB, Jung WI, Nutt RE, Cherry SR, Claussen CD, Pichler BJ.
Radiology. 2007 Sep;244(3):807-14.
Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice
Angstenberger M, Wegener JW, Pichler BJ, Judenhofer MS, Feil S, Alberti S, Feil R, Nordheim A.
Gastroenterology. 2007 Dec;133(6):1948-59.
Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent
Probst J, Weide B, Scheel B, Pichler BJ, Hoerr I, Rammensee HG, Pascolo S.
Gene Ther. 2007 Aug;14(15):1175-80.
Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice
Kneilling M, Hultner L, Pichler BJ, Mailhammer R, Morawietz L, Solomon S, Eichner M, Sabatino J, Biedermann T, Krenn V, Weber WA, Illges H, Haubner R, Rocken M.
Arthritis Rheum. 2007 Jun;56(6):1806-16.
A hyperspectral fluorescence system for 3D in vivo optical imaging
G. Zavattini, S. Vecchi, G. Mitchell, U. Weisser, R.M. Leahy, B.J. Pichler, D.J. Smith, S.R. Cherry
Phys Med Biol. 2006 Apr 21;51(8):2029-43.
Optical imaging of experimental arthritis using allogeneic leukocytes labelled with a near-infrared fluorescent probe
G.H. Simon, H.E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Sabarowski, S. Demos, J. Duyster, B.J. Pichler
Eur J Nucl Med Mol Imaging. 2006 Sep;33(9):998-1006.
Performance test of a LSO-APD detector in a 7 Tesla MRI scanner for simultaneous PET-MR imaging.
B.J. Pichler, M.S. Judenhofer, C. Catana, J.H. Walton, M. Kneilling, R.E. Nutt, S.B. Siegel, C.D. Claussen, S.R. Cherry
J Nucl Med. 2006 Apr;47(4):639-47.
Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner
Catana C, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Cherry SR.
J Nucl Med. 2006 Dec;47(12):1968-76.
Characterization and readout of MADPET-II detector modules: validation of a unique design concept for high resolution small animal PET
D.P. McElroy, W. Pimpl, B.J. Pichler, M. Rafecas, T. Schüler, S.I. Ziegler
IEEE. Trans. Nucl. Sci. 2005 Apr 11;52(1):199-204
Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors
M.S. Judenhofer, B.J. Pichler, S.R. Cherry
Phys Med Biol. 2005 Jan 7;50(1):29-44.
Imaging of delayed type hypersensitivity reaction by positron emission tomography and [18F]Galacto-RGD
B.J. Pichler, M. Kneilling, R. Haubner, H. Braumüller, M. Schwaiger, M. Röcken, W.A. Weber
J Nucl Med. 2005 Jan;46(1):184-9.