2023

2023

• Cerebrovascular Gi Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia
  Castaneda-Vega S, Beer-Hammer S, Leiss V, Napieczyńska H, Vuozzo M, Schmid AM, Zeng H, He Y, Kohlhofer U, Gonzalez-Menendez I, Quintanilla-Martinez L, Hempel JM, Gollasch M, Yu X, Pichler BJ, Nürnberg B.
  Mol Imaging Biol. 2023 Apr;25(2):363-374
• First-in-Humans PET/MRI of In Vivo GD2 Expression in Osteosarcoma
  Trautwein NF, Reischl G, Seitz C, Dittmann H, Seith F, Scheuermann S, Feuchtinger T, Dombrowski F, Handgretinger R, Fuchs J, Pichler B, Fougère C, Schwenck J
  J Nucl Med. 2023 Feb;64(2):337-338
• MR-spectroscopy in metachromatic leukodystrophy: A model free approach and clinical correlation
  Feldmann J, Martin P, Bender B, Laugwitz L, Zizmare L, Trautwein C, Krägeloh-Mann I, Klose U, Groeschel S
  Neuroimage Clin. 2023;37:103296
• Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine
  Ionescu TM, Amend M, Watabe T, Hatazawa J, Maurer A, Reischl G, Pichler BJ, Wehrl HF, Herfert K
  J Nucl Med. 2023 Mar;64(3):466-471
• Preclinical Identification Of Tumor-Draining Lymph Nodes Using a Multimodal Non-invasive In vivo Imaging Approach
  Knopf P, Stowbur D, Hoffmann SHL, Fransen MF, Schwenck J, Pichler BJ, Kneilling M
  Mol Imaging Biol. 2023 Jan 4, Epub ahead of print
• TGF-Beta Modulates the Integrity of the Blood Brain Barrier In Vitro, and Is Associated with Metabolic Alterations in Pericytes
  Schumacher L, Slimani R, Zizmare L, Ehlers J, Kleine Borgmann F, Fitzgerald JC, Fallier-Becker P, Beckmann A, Grißmer A, Meier C, El-Ayoubi A, Devraj K, Mittelbronn M, Trautwein C, Naumann U
  Biomedicines. 2023 Jan 14;11(1):214
• Radiolabeled GPVI-Fc for PET imaging of multiple extracellular matrix fibers: A new look into pulmonary fibrosis progression
  Isser S, Maurer A, Reischl G, Schaller M, Gonzalez-Menendez I, Quintanilla-Martinez L, Gawaz M, Pichler BJ, Beziere N
  J Nucl Med. 2023 Jan 26, Epub ahead of print
• Design and performance simulation studies of a breast PET insert integrable into a clinical whole-body PET/MRI scanner
  Pommranz CM, Schmidt FP, Mannheim JG, Diebold SJ, Tenzer C, Santangelo A, Pichler BJ
  Phys Med Biol. 2023 Feb 28;68(5)
• Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice
  Feil S, Stowbur D, Schörg BF, Ehrlichmann W, Reischl G, Kneilling M, Pichler BJ, Feil R
  Circ Res. 2023 Mar 17;132(6):747-750
• Avascular fat grafts show lower volume retention but higher hypoxia, angiogenesis, adipocyte proliferation, and macrophage infiltration than vascularized adipocutaneous flaps in an in vivo pilot mouse study Fat grafting vs. flap transfer in mice
  Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli AK, Schulte M, Hoffmann SH, Garvalov BK, Schreiber C, Takamiya M, Sleeman JP, Schmidt VJ, Kneser U, Pichler BJ, Dimmler A, Thiele W
  Plast Reconstr Surg. 2023 Jan 3, Epub ahead of print
• Imaging Techniques in Pharmacological Precision Medicine
  Freidel L, Li S, Choffart A, Kuebler L, Martins AF
  Handb Exp Pharmacol. 2023 Mar 13, Epub ahead of print
• Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia
  Schütte JP, Manke MC, Hemmen K, Münzer P, Schörg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KAL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O
  Circ Res. 2023 Mar 31;132(7):e96-e113
• Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke
  Patzwaldt K, Berezhnoy G, Ionescu T, Schramm L, Wang Y, Owczorz M, Calderón E, Poli S, Serna Higuita LM, Gonzalez-Menendez I, Quintanilla-Martinez L, Herfert K, Pichler B, Trautwein C, Castaneda-Vega S
  Brain Commun. 2023 Mar 29;5(2):fcad099
• Machine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models.
  Boeke S, Winter RM, Leibfarth S, Krueger MA, Bowden G, Cotton J, Pichler BJ, Zips D, Thorwarth D.
  Eur J Nucl Med Mol Imaging. 2023 May 6.
• Evaluation of a modular all-in-one high-resolution PET detector and readout electronics setup.
  Schmidt FP, Krämer JC, Parl C, Schmand M, Pichler BJ.
  Phys Med Biol. 2023 May 29;68(11).
• The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β.
  Di Nanni A, Saw RS, Bowden GD, Bidesi NSR, Bjerregaard-Andersen K, Korat Š, Herth MM, Pichler BJ, Herfert K, Maurer A.
  Molecules. 2023 May 10;28(10):4001.
• Advances in PET imaging of cancer.
  Schwenck J, Sonanini D, Cotton JM, Rammensee HG, la Fougère C, Zender L, Pichler BJ.
  Nat Rev Cancer. 2023 May 31.
• Characterization of the partial volume effect along the axial field-of-view of the Biograph Vision Quadra total-body PET/CT system for multiple isotopes.
  Mannheim JG, Rausch I, Conti M, la Fougère C, Schmidt FP.
  EJNMMI Phys. 2023 May 27;10(1):33.
• Stratification of ovarian cancer borderline from high-grade serous carcinoma patients by quantitative serum NMR spectroscopy of metabolites, lipoproteins, and inflammatory markers.
  Bae G, Berezhnoy G, Koch A, Cannet C, Schäfer H, Kommoss S, Brucker S, Beziere N, Trautwein C.
  Front Mol Biosci. 2023 Apr 19;10:1158330.
• Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data.
  Katiyar P, Schwenck J, Frauenfeld L, Divine MR, Agrawal V, Kohlhofer U, Gatidis S, Kontermann R, Königsrainer A, Quintanilla-Martinez L, la Fougère C, Schölkopf B, Pichler BJ, Disselhorst JA.
  Nat Biomed Eng. 2023 Jun 5.
• In vivo imaging of CD8+ T cells in metastatic cancer patients: first clinical experience with simultaneous [89Zr]Zr-Df-IAB22M2C PET/MRI.
  Schwenck J, Sonanini D, Seyfried D, Ehrlichmann W, Kienzle G, Reischl G, Krezer P, Wilson I, Korn R, Gonzalez-Menendez I, Quintanilla-Martinez L, Seith F, Forschner A, Eigentler T, Zender L, Röcken M, Pichler BJ, Flatz L, Kneilling M, la Fougere C.
  Theranostics. 2023 Apr 17;13(8):2408-2423.
• Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome patients.
  Berezhnoy G, Bissinger R, Liu A, Cannet C, Schäfer H, Kienzle K, Bitzer M, Häberle H, Göpel S, Trautwein C, Singh Y.
  Front Immunol. 2023 May 9;14:1144224.
• Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling.
  Kotsiliti E, Leone V, Schuehle S, ... , Zizmare L, ... , Trautwein C, ..., Heikenwalder M.
  J Hepatol. 2023 May 9:S0168-8278(23)00325-2.
• PET/MRI and Bioluminescent Imaging Identify Hypoxia as a Cause of Programmed Cell Death Ligand 1 Image Heterogeneity.
  Parkins KM, Krishnamachary B, Jacob D, Kakkad SM, Solaiyappan M, Mishra A, Mironchik Y, Penet MF, McMahon MT, Knopf P, Pichler BJ, Nimmagadda S, Bhujwalla ZM.
  Radiol Imaging Cancer 2023 Jul;5(4):e220138.
• A consensus protocol for functional connectivity analysis in the rat brain.
  Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, ... , Ionescu T, ...Marciano S., ..., Herfert K., ... ,Devenyi GA, Chakravarty MM, Hess A
  Nat Neurosci. 2023 Apr;26(4):673-681.
• Pyruvate-conjugation of PEGylated liposomes for targeted drug delivery to retinal photoreceptors.
  Christensen G, Chen Y, Urimi D, Zizmare L, Trautwein C, Schipper N, Paquet-Durand F.
  Biomed Pharmacother. 2023 Jul;163:114717.
• Long-term prognostic factors for PRRT in neuroendocrine tumors.
  Trautwein NF, Schwenck J, Jacoby J, Reischl G, Fiz F, Zender L, Dittmann H, Hinterleitner M, la Fougère C.
  Front Med (Lausanne). 2023 Jun 9;10:1169970.
• Diagnostic Performance of Dynamic Whole-Body Patlak [18F]FDG-PET/CT in Patients with Indeterminate Lung Lesions and Lymph Nodes.
  Weissinger M, Atmanspacher M, Spengler W, Seith F, Von Beschwitz S, Dittmann H, Zender L, Smith AM, Casey ME, Nikolaou K, Castaneda-Vega S, la Fougère C.
  J Clin Med. 2023 Jun 9;12(12):3942.
• A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB.
  Di Nanni A, Saw RS, Battisti UM, Bowden GD, Boeckermann A, Bjerregaard-Andersen K, Pichler BJ, Herfert K, Herth MM, Maurer A.
  ACS Omega. 2023 Aug 15;8(34):31450-31467.
• Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA.
  Golombek S, Hoffmann T, Hann L, Mandler M, Schmidhuber S, Weber J, Chang YT, Mehling R, Ladinig A, Knecht C, Leyens J, Schlensak C, Wendel HP, Schneeberger A, Avci-Adali M.
  Mol Ther Nucleic Acids. 2023 Aug 2;33:642-654.
• Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future.
  Lai J, Wang B, Petrik M, Beziere N, Hammoud DA.
  J Infect Dis. 2023 Oct 3;228(Suppl 4):S259-S269.
• The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection.
  Alberto S, Ordonez AA, Arjun C, Aulakh GK, Beziere N, Dadachova E, Ebenhan T, Granados U, Korde A, Jalilian A, Lestari W, Mukherjee A, Petrik M, Sakr T, Cuevas CLS, Welling MM, Zeevaart JR, Jain SK, Wilson DM.
  Nucl Med. 2023 Nov;64(11):1676-1682.
• Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes.
  Focken J, Scheurer J, Jäger A, Schürch CM, Kämereit S, Riel S, Schaller M, Weigelin B, Schittek B.
  Cell Rep. 2023 Oct 31;42(10):113148.
• Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.
  Singh Y, Trautwein C, Romani J, Salker MS, Neckel PH, Fraccaroli I, Abeditashi M, Woerner N, Admard J, Dhariwal A, Dueholm MKD, Schäfer KH, Lang F, Otzen DE, Lashuel HA, Riess O, Casadei N.
  Mol Neurodegener. 2023 Jul 4;18(1):44.
• Measuring the Release of Lactate from Wild-Type and rd1 Mouse Retina.
  Chen Y, Zizmare L, Trautwein C, Paquet-Durand F.
  Adv Exp Med Biol. 2023;1415:429-434.
• Metabolomic profiling of CSF and blood serum elucidates general and sex-specific patterns for mild cognitive impairment and Alzheimer's disease patients.
  Berezhnoy G, Laske C, Trautwein C.
  Front Aging Neurosci. 2023 Aug 24;15:1219718.
• Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
  McKay NS, Gordon BA, Hornbeck RC, ..., Rahmani F, Swisher L, ..., Farlow MR, la Fougère C, Fox NC, ..., Noble JM, Reischl G, Rowe C, Salloway S, Sanchez-Valle R, ..., Benzinger TLS; Dominantly Inherited Alzheimer Network.
  Nat Neurosci. 2023 Aug;26(8):1449-1460.
• Cell therapy by mesenchymal stromal cells versus myoblasts in a pig model of urinary incontinence.
  Knoll J, Amend B, Harland N, Isser S, Beziere N, Kraushaar U, Stenzl A, Aicher W.
  Tissue Eng Part A. 2023 Nov 7.
• FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer.
  Menzel F, Cotton J, Klein T, Maurer A, Ziegler T, Neumaier JM
  J Flow Chem 13, 247–256 (2023).
• Mapping tissue heterogeneity in solid tumours using PET-MRI and machine learning.
  Katiyar P, Pichler BJ
  Nat. Biomed. Eng 7, 969–970 (2023).
• Non-invasive estimation of split renal function from routine 68Ga-SSR-PET/CT scans.
  Weissinger M, Seyfried KC, Ursprung S, Castaneda-Vega S, Seith F, von Beschwitz S, Vogel J, Ghibes P, Nikolaou K, la Fougère C, Dittmann H.
  Front Med (Lausanne). 2023 Jun 28;10:1169451.
• The design of functional proteins using tensorized energy calculations.
  Maksymenko K, Maurer A, Aghaallaei N, Barry C, Borbarán-Bravo N, Ullrich T, Dijkstra TMH, Hernandez Alvarez B, Müller P, Lupas AN, Skokowa J, ElGamacy M.
  Cell Rep Methods. 2023 Aug 15;3(8):100560.
• XBP1 promotes NRASG12D pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS.
  Salimi A, Schemionek-Reinders M, Huber M, Vieri M, Patterson JB, Alten J, Brümmendorf TH, Kharabi Masouleh B, Appelmann I.
  J Cell Mol Med. 2023 Nov;27(21):3363-3377.
• Editorial: Imaging brain molecular connectivity in health and disease.
  Sala A, Herfert K, Gonzalez-Escamilla G, Caminiti SP, Bertoglio D.
  Front Hum Neurosci. 2023 Oct 10;17:1298382.
• Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD+ pathway and SIRT1 activation.
  Lonati C, Berezhnoy G, Lawler N, Masuda R, Kulkarni A, Sala S, Nitschke P, Zizmare L, Bucci D, Cannet C, Schäfer H, Singh Y, Gray N, Lodge S, Nicholson J, Merle U, Wist J, Trautwein C.
  Clin Chem Lab Med. 2023 Nov 14.
• Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
  Knopf P, Stowbur D, Hoffmann SHL, Hermann N, Maurer A, Bucher V, Poxleitner M, Tako B, Sonanini D, ..., Sinharay S, ..., Reckmann F, ..., Bhujwalla ZM, ..., Pagel MD, ...,Martins AF, Pichler BJ, ..., Kneilling M.
  Mol Cancer. 2023 Dec 15;22(1):207.
• Stratification of hypertension and SARS-CoV-2 infection by quantitative NMR spectroscopy of human blood serum.
  Kazenwadel J, Berezhnoy G, Cannet C, Schäfer H, Geisler T, Rohlfing AK, Gawaz M, Merle U, Trautwein C.
  Commun Med (Lond). 2023 Oct 16;3(1):145.
• Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients.
  Lichtensteiger C, Koblischke M, Berner F, ..., Kneilling M, Cozzio A, Pop O, Bomze D, Bergthaler A, Hasan Ali O, Aberle J, Flatz L.
  J Autoimmun. 2023 Oct 10;140:103118.
• Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET/CT Scanner.
  Calderón E, Schmidt FP, Lan W, Castaneda-Vega S, Brendlin AS, Trautwein NF, Dittmann H, la Fougère C, Kiefer LS.
  Diagnostics (Basel). 2023 Oct 18;13(20):3240.
• Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells.
  Wagner TR, Blaess S, Leske IB, Frecot DI, Gramlich M, Traenkle B, Kaiser PD, Seyfried D, Maier S, Rezza A, Sônego F, Thiam K, Pezzana S, Zeck A, Gouttefangeas C, Scholz AM, Nueske S, Maurer A, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U.
  Front Immunol. 2023 Dec 18;14:1264179.
• Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner.
  Linder PM, Lan W, Trautwein NF, Brosch-Lenz J, von Beschwitz S, Kupferschläger J, Reischl G, Grözinger G, Dittmann H, la Fougère C, Schmidt FP.
  Diagnostics (Basel). 2023 Nov 9;13(22):3418.
• T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease.
  Rahmani F, Brier MR, ..., Reischl G, Schofield PR, Oh H, Levin J, Vöglein J, Cash DM, Yakushev I, Ikeuchi T, Klunk WE, Morris JC, Bateman RJ, Benzinger TLS; Dominantly Inherited Alzheimer Network (DIAN).
  Hum Brain Mapp. 2023 Dec 15;44(18):6375-6387.
• On the Use of Artificial Intelligence for Dosimetry of Radiopharmaceutical Therapies.
  Brosch-Lenz JF, Delker A, Schmidt F, Tran-Gia J.
  Nuklearmedizin. 2023 Dec;62(6):379-388.
• Evaluation of the MRI compatibility of PET detectors modules for organ-specific inserts in a 3T and 7T MRI scanner.
  Schmidt FP, Allen MS, Ladebeck R, Breuer J, Judenhofer M, Schmand M, Catana C, Pichler BJ.
  Med Phys. 2023 Dec 27.
• Impact of the maximum ring difference on image quality and noise characteristics of a total-body PET/CT scanner.
  Schmidt FP, Mannheim JG, Linder PM, Will P, Kiefer LS, Conti M, la Fougère C, Rausch I.
  Z Med Phys. 2023 Oct 20:S0939-3889(23)00113-7.
• Radiochemistry: A Hot Field with Opportunities for Cool Chemistry.
  Bowden GD, Scott PJH, Boros E.
  ACS Cent Sci. 2023 Nov 14;9(12):2183-2195.