2021

2021

• Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
  Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, Müller A, Fehrenbacher B, Gonzalez-Menendez I, Quintanilla-Martinez L, Schröder K, Brandes RP, Schaller M, Ruf W, Eichner M, Ghoreschi K, Röcken M, Pichler BJ, Kneilling M
  Theranostics. 2021 Jan 1;11(2):470-490
• Rapid and precise delivery of cells in the urethral sphincter complex by a novel needle-free waterjet technology
  Linzenbold W, Jäger L, Stoll H, Abruzzese T, Harland N, Bézière N, Fech A, Enderle M, Amend B, Stenzl A, Aicher WK
  BJU Int. 2021 Apr;127(4):463-472
• Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients
  Thaiss WM, Gatidis S, Sartorius T, Machann J, Peter A, Eigentler TK, Nikolaou K, Pichler BJ, Kneilling M
  Cancer Immunol Immunother. 2021 May;70(5):1263-1275
• [11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates
  Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K
  Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1759-1772
• Non invasive in vivo monitoring of dimethyl fumarate treatment in EAE by assessing the glucose metabolism in secondary lymphoid organs
  Brück J, Calaminus C, Hoffmann SHL, Schwenck J, Holstein J, Yazdi AS, Pichler B, Kneilling M, Ghoreschi K
  Eur J Immunol. 2021 Apr;51(4):1006-1009
• An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer
  Zekri L, Vogt F, Osburg L, Müller S, Kauer J, Manz T, Pflügler M, Maurer A, Heitmann JS, Hagelstein I, Märklin M, Hörner S, Todenhöfer T, Calaminus C, Stenzl A, Pichler B, la Fougère C, Schneider MA, Rammensee HG, Zender L, Sipos B, Salih HR, Jung G
  EMBO Mol Med. 2021 Feb 5;13(2):e11902
• Machine learning identifies stroke features between species
  Castaneda-Vega S, Katiyar P, Russo F, Patzwaldt K, Schnabel L, Mathes S, Hempel JM, Kohlhofer U, Gonzalez-Menendez I, Quintanilla-Martinez L, Ziemann U, la Fougere C, Ernemann U, Pichler BJ, Disselhorst JA, Poli S
  Theranostics. 2021 Jan 1;11(6):3017-3034. doi: 10.7150/thno.51887
• Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI
  Chirayil S, Jordan VC, Martins AF, Paranawithana N, Ratnakar SJ, Sherry AD
  Inorg Chem. 2021 Jan 28. doi: 10.1021/acs.inorgchem.0c02688. Epub ahead of print
• Tissue Hypoxia and Alterations in Microvascular Architecture Predict Glioblastoma Recurrence in Humans
  Stadlbauer A, Kinfe TM, Eyüpoglu I, Zimmermann M, Kitzwögerer M, Podar K, Buchfelder M, Heinz G, Oberndorfer S, Marhold F
  Clin Cancer Res. 2021 Mar 15;27(6):1641-1649
• A T 2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach
  Zhang Y , Zhao K , He H , Wan S , Martins AF , Zhang L , Liu K
  Dalton Trans. 2021 Feb 14;50(6):2014-2017
• Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging
  Mannheim JG, Cheng JK, Vafai N, Shahinfard E, English C, McKenzie J, Zhang J, Barlow L, Sossi V
  EJNMMI Phys. 2021 Feb 26;8(1):20
• A single pot template reaction towards a manganese based T1 contrast agent.
  Anbu S, Hoffmann SHL, Carniato F, Kenning L, Price TW, Prior TJ, Botta M, Martins AF, Stasiuk GJ
  Angew Chem Int Ed Engl. 2021 Feb 24. doi: 10.1002/anie.202100885. Epub ahead of print.
• Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment
  Henneberg S, Hasenberg A, Maurer A, Neumann F, Bornemann L, Gonzalez-Menendez I, Kraus A, Hasenberg M, Thornton CR, Pichler BJ, Gunzer M, Beziere N
  Nat Commun. 2021 Mar 17;12(1):1707
• Elucidating the complementarity of resting-state networks derived from dynamic [ 18 F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI
  Ionescu TM, Amend M, Hafiz R, Biswal BB, Wehrl HF, Herfert K, Pichler BJ
  Neuroimage. 2021 Apr 10;236:118045
• [18F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the "Negative" Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients.
  Smaxwil C, Aschoff P, Reischl G, Busch M, Wagner J, Altmeier J, Ploner O, Zielke A
  J Clin Med. 2021 Apr 13;10(8):1648. doi: 10.3390/jcm10081648
• The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
  Nording H, Baron L, Haberthür D, ... , Feil R, Pichler B, Erdmann J, ... , Gawaz M, Langer HF
  Nat Commun. 2021 Jun 7;12(1):3352
• Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery
  Slaats J, Dieteren CE, Wagena E, Wolf L, Raaijmakers TK, van der Laak JA, Figdor CG, Weigelin B, Friedl P
  Cancer Immunol Res. 2021 Jul 5
• Mathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells
  Beck RJ, Weigelin B, Beltman JB
  Cancers (Basel). 2021 May 24;13(11):2567
• 131Iodine-GD2-ch14.18 scintigraphy to evaluate option for radioimmunotherapy in patients with advanced tumors
  Zhang Y, Kupferschlaeger J, Lang P, Reischl G, Handgretinger R, la Fougere C, Dittmann H
  J Nucl Med. 2021 May 28:jnumed.120.261854
• Central insulin modulates dopamine signaling in the human striatum
  Kullmann S, Blum D, Jaghutriz BA, Gassenmaier C, Bender B, Häring HU, Reischl G, Preissl H, la Fougère C, Fritsche A, Reimold M, Heni M
  J Clin Endocrinol Metab. 2021 Jun 15:dgab410
• LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
  Rudalska R, Harbig J, ... , Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D
  Nat Cancer. 2021 Feb;2(2):201-217
• Recent advances in intravital microscopy for preclinical research
  Giampetraglia M, Weigelin B
  Curr Opin Chem Biol. 2021 Aug;63:200-208
• Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib
  Bowden GD, Chailanggar N, Pichler BJ, Maurer A
  Org Biomol Chem. 2021 Aug 28;19(32):6995-7000
• Low-dose total body irradiation facilitates antitumoral Th1 immune responses
  Sonanini D, Griessinger CM, Schörg BF, Knopf P, Dittmann K, Röcken M, Pichler BJ, Kneilling M
  Theranostics. 2021 Jun 16;11(16):7700-7714
• SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells
  Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, Ossowski S, Salker MS, Casadei N, Riess O; Deutsche COVID-19 OMICS Initiate (DeCOI)
  Heliyon. 2021 Jun;7(6):e07147
• Glioma-Specific Diffusion Signature in Diffusion Kurtosis Imaging.
  Hempel JM, Brendle C, Adib SD, Behling F, Tabatabai G, Castaneda Vega S, Schittenhelm J, Ernemann U, Klose U
  Imaging. J Clin Med. 2021 May 26;10(11):2325
• Synthesis and Biological Evaluation of a Radiolabeled PET (Positron Emission Tomography) Probe for Visualization of In Vivo α-Fucosidase Expression
  Cotton J, Goehring CM, Kuehn A, Maurer A, Fuchs K, Pichler BJ
  harmaceuticals (Basel). 2021 Jul 29;14(8):745
• Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity.
  Ionescu TM, Amend M, Hafiz R, Biswal BB, Maurer A, Pichler BJ, Wehrl HF, Herfert K.
  Neuroimage. 2021 Nov;243:118501.
• Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.
  Weigelin B, den Boer AT, Wagena E, Broen K, Dolstra H, de Boer RJ, Figdor CG, Textor J, Friedl P
  Nat Commun. 2021 Sep 1;12(1):5217
• A Protein-Based Biosensor for Detecting Calcium by Magnetic Resonance Imaging
  Ozbakir HF, Miller ADC, Fishman KB, Martins AF, Kippin TE, Mukherjee A
  ACS Sens. 2021 Sep 24;6(9):3163-3169.
• Covalent 18F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging.
  Stotz S, Bowden GD, Cotton JM, Pichler BJ, Maurer A.
  Pharmaceuticals (Basel). 2021 Sep 3;14(9):897.
• Alpha-Synuclein PET Tracer Development-An Overview about Current Efforts.
  Korat Š, Bidesi NSR, Bonanno F, Di Nanni A, Hoàng ANN, Herfert K, Maurer A, Battisti UM, Bowden GD, Thonon D, Vugts D, Windhorst AD, Herth MM.
  Pharmaceuticals (Basel). 2021 Aug 26;14(9):847.
• The Role of Positron Emission Tomography/Computed Tomography (PET/CT) for Staging and Disease Response Assessment in Localized and Locally Advanced Pancreatic Cancer.
  Ghidini M, Vuozzo M, Galassi B, Mapelli P, Ceccarossi V, Caccamo L, Picchio M, Dondossola D.
  Cancers (Basel). 2021 Aug 18;13(16):4155.
• Universal Gene Correction Approaches for β-hemoglobinopathies Using CRISPR-Cas9 and Adeno-Associated Virus Serotype 6 Donor Templates.
  Lamsfus-Calle A, Daniel-Moreno A, Ureña-Bailén G, Rottenberger J, Raju J, Epting T, Marciano S, Heumos L, Baskaran P, S Antony J, Handgretinger R, Mezger M.
  CRISPR J. 2021 Apr;4(2):207-222.
• ADC-Based Stratification of Molecular Glioma Subtypes Using High b-Value Diffusion-Weighted Imaging.
  Nuessle NC, Behling F, Tabatabai G, Castaneda Vega S, Schittenhelm J, Ernemann U, Klose U, Hempel JM.
  J Clin Med. 2021 Aug 4;10(16):3451.
• Detection of diabetes from whole-body MRI using deep learning.
  Dietz B, Machann J, Agrawal V, Heni M, Schwab P, Dienes J, Reichert S, Birkenfeld AL, Häring HU, Schick F, Stefan N, Fritsche A, Preissl H, Schölkopf B, Bauer S, Wagner R.
  JCI Insight. 2021 Nov 8;6(21):e146999.
• DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer.
  Bowden GD, Stotz S, Kinzler J, Geibel C, Lämmerhofer M, Pichler BJ, Maurer A.
  J Med Chem. 2021 Nov 11;64(21):15690-15701.
• Physiological MRI Biomarkers in the Differentiation Between Glioblastomas and Solitary Brain Metastases.
  Heynold E, Zimmermann M, Hore N, Buchfelder M, Doerfler A, Stadlbauer A, Kremenevski N.
  Mol Imaging Biol. 2021 Oct;23(5):787-795.
• Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI.
  Stadlbauer A, Marhold F, Oberndorfer S, Heinz G, Zimmermann M, Buchfelder M, Heynold E, Kinfe TM.
  Metabolites. 2021 Sep 29;11(10):668.
• Hypoxia and Microvascular Alterations Are Early Predictors of IDH-Mutated Anaplastic Glioma Recurrence.
  Stadlbauer A, Oberndorfer S, Heinz G, Zimmermann M, Kinfe TM, Doerfler A, Buchfelder M, Kremenevski N, Marhold F.
  Cancers (Basel). 2021 Apr 9;13(8):1797.
• Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.
  Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender L.
  Nat Commun. 2021 Dec 1;12(1):7005.
• Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells.
  Traenkle B, Kaiser PD, Pezzana S, Richardson J, ... , Jakobi M, Schneiderhan-Marra N, Schaller M, Maurer A, Gouttefangeas C, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U.
  Front Immunol. 2021 Dec 9;12:799910.
• Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting
  Seitz CM, Mittelstaet J, ... , Krahl AC, Knopf P, Schroeder S, ... , Schilbach K, Kneilling M, Pichler B, Lock D, Kotter B, Dapa S, Miltenyi S, Kaiser A, Lang P, Handgretinger R, Schlegel P
  Oncoimmunology. 2021 Dec 2;10(1):2003532.