Shortly after introduction of in vivo magnetic resonance imaging (MRI) also first localized in vivo magnetic resonance spectra (MRS) were acquired in the early 1980s. In vivo MRS has evolved during the last 25 years in terms of localization quality and spatial resolution, acquisition speed, artifact suppression, number of detectable metabolites and quantification precision and has profited especially from the significant increase of magnetic field strength that recently became available for in vivo investigations. Today it allows for non-invasive and non-ionizing determination of tissue concentrations and metabolic turn-over rates of various metabolites and compounds in animals or humans, is applied for clinical diagnostics and has established as an important tool for physiological research. 

Magnetic Resonance Spectroscopy Methodology

Current projects of specific interest include

•        spectroscopy localization

•        accelerated MRSI and related MRSI reconstruction

•        functional 1H and 13C MRS

•        motion correction methods for body MRS (spinal cord, myocardium)

•        2D resolved and edited MRS

•        spectral fitting

•       ERETIC reference standard

Ultra-high field magnetic resonance methodology

Current projects of specific interest include

•        radiofrequency pulse design

•       parallel transmit and receive technology (RF coil arrays, EM simulation and optimization)

•       real-time feedback, dynamic, higher order B0 shim technology

Multimodal high-field MRS and MRI for physiological research

Current physiological studies focus on the following topics:

•       Psychiatric Disorders: major depressive disorder and mechanism of action of related

       therapy forms

•        Neurological Disorders: spinal cord pathology and regeneration

•        Muscle physiology: skeletal and myocardial muscle energy metabolism in metabolic

       syndrome

More information's on MR Spectroscopy and Ultra-High Field Methodology