Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma. Magn Reson Med. 2016 Jan 27; Authors: Zaiss M, Windschuh J, Goerke S, Paech D, Meissner JE, Burth S, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Ladd ME, Bachert P, Radbruch A

CEST - MRI is an MRI technique that enables detection of proteins and metabolites in the body

protein CEST

Chemical exchange saturation transfer (CEST) effects such as amide-CEST effect originating from proteins correlate with intracellular pH and protein concentration. Correlations that are highly interesting for cancer diagnosis. Comparison with gadolinium contrast enhancing longitudinal relaxation time-weighted images revealed that amide-CEST contrast forms a unique contrast that delineates tumor regions and show remarkable overlap with the gadolinium contrast enhancement.


The idea of the technique is to administer natural D-glucose as a contrast agent instead of conventional contrast agents. Glucose can be detected by CEST imaging, thus, the promise of the technique is to give a subject a drink of soda with high sugar and see if tumors light up due to their enhanced metabolism.

The glucoCEST project at MPI is part of the EU Project GLINT


For both applications we develop fast imaging techniques for 3 Tesla, 7 Tesla, and 9.4 Tesla human scanners, as well as preclinical systems. Evaluation software is shared on
Find previous publications on pubmed and more information on the CEST project website at MPI.