Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma. Magn Reson Med. 2016 Jan 27; Authors: Zaiss M, Windschuh J, Goerke S, Paech D, Meissner JE, Burth S, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Ladd ME, Bachert P, Radbruch A
CEST and glucoCEST MRI
CEST - MRI is an MRI technique that enables detection of proteins and metabolites in the body
Chemical exchange saturation transfer (CEST) effects such as amide-CEST effect originating from proteins correlate with intracellular pH and protein concentration. Correlations that are highly interesting for cancer diagnosis. Comparison with gadolinium contrast enhancing longitudinal relaxation time-weighted images revealed that amide-CEST contrast forms a unique contrast that delineates tumor regions and show remarkable overlap with the gadolinium contrast enhancement.
The idea of the technique is to administer natural D-glucose as a contrast agent instead of conventional contrast agents. Glucose can be detected by CEST imaging, thus, the promise of the technique is to give a subject a drink of soda with high sugar and see if tumors light up due to their enhanced metabolism.
The glucoCEST project at MPI is part of the EU Project GLINT www.glint-project.eu