2025

2025

• Study on the mechanism of 17-Hydroxy-jolkinolide B on anaplastic thyroid cancer cell.
  Yang L, Shi W, Li D, Shen Y, Li N, Meng Z.
  Am J Med Sci. 2025 Mar;369(3):405-412.
• Piperazine-based P2X4 receptor antagonists.
  Erlitz KS, Siutkina AI, Prinz AK, Koch O, Kalinin DV, Junker A.
  Arch Pharm (Weinheim). 2025 Jan;358(1):e2400860.
• Phenol (bio)isosteres in drug design and development.
  Dunker C, Schlegel K, Junker A.
  Arch Pharm (Weinheim). 2025 Jan;358(1):e2400700.
• 2-[18F]F-p-Aminobenzoic Acid Specifically Detects Infective Endocarditis in Positron Emission Tomography.
  Schulte J, Maurer A, Domogalla LC, Steinacker N, Wadle C, Kinzler J, Eder M, von Zur Mühlen C, Krohn-Grimberghe M, Eder AC.
  Infect Dis. 2025 Mar 17;231(3):e536-e544.
• A digital twin of the Biograph Vision Quadra long axial field of view PET/CT: Monte Carlo simulation and image reconstruction framework.
  Pommranz CM, Elmoujarkach EA, Lan W, Cabello J, Linder PM, Vo HP, Mannheim JG, Santangelo A, Conti M, la Fougère C, Rafecas M, Schmidt FP.
  EJNMMI Phys. 2025 Mar 31;12(1):31.
• Metabolic PCTA-Based Shift Reagents for the Detection of Extracellular Lactate Using CEST MRI.
  Chiaffarelli R, Cruz PF, Cotton J, Kelm T, Lee S, Ghaderian M, Zimmermann M, Geraldes CFGC, Jurek P, Martins AF.
  JACS Au. 2025 Feb 10;5(2):779-790.
• Optimizing stroke lesion segmentation: A dual-approach using Gaussian mixture models and nnU-Net.
  Mannel A, Khunt D, Agrawal V, Schelling K, Calderón E, la Fougère C, Castaneda-Vega S.
  Comput Biol Med. 2025 Jun;192(Pt A):110221.
• Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner.
  Trautwein NF, Calderón E, Linder PM, Reischl G, Driessen P, Lan W, Brendlin AS, Groß T, Dittmann H, Hinterleitner M, Fougère C, Schmidt FP, Kiefer LS.
  EJNMMI Phys. 2025 Feb 5;12(1):13.
• One-day dual-tracer examination in neuroendocrine neoplasms: a real advantage of low activity LAFOV PET imaging.
  Calderón E, Kiefer LS, Schmidt FP, Lan W, Brendlin AS, Reinert CP, Singer S, Reischl G, Hinterleitner M, Dittmann H, la Fougère C, Trautwein NF.
  Eur J Nucl Med Mol Imaging. 2025 Jun;52(7):2463-2476.
• Exploring molecular imaging to investigate immune checkpoint inhibitor-related toxicity.
  Peeters E, van Genugten EAJ, Heskamp S, de Vries IJM, van Herpen C, Koenen HJPM, Kneilling M, van der Post RS, van Dop WA, Westdorp H, Aarntzen E.
  J Immunother Cancer. 2025 May 7;13(5):e011009.
• 68Ga-Labeled Glycopeptides as Effective Tools for Liver Function Imaging.
  Zierke MA, Rangger C, Samadikhah K, Schmid AM, Haubner R.
  Mol Pharm. 2025 Mar 3;22(3):1677-1685.
• Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19.
  Bae G, Yang Z, Bucci D, Wegner C, Schäfer H, Singh Y, Lonati C, Trautwein C.
  Metabolomics. 2025 May 7;21(3):65.
• Impact of Mechanical Ventilation and Anesthesia on PET Tracer Kinetics for Combined PET/fMRI Studies in Rats
  Ma Y, Kuebler L, Haas S, Maurer A, Herfert K.
  Mol Imaging Biol. 2025 May 14.
• n vivo molecular imaging of breast cancer metabolic heterogeneity using [1-13C]pyruvate-d3 hyperpolarized by reversible exchange with parahydrogen.
  Petersen S, Nagel L, Groß PR, de Maissin H, Willing R, Heß L, Mitschke J, Klemm N, Treiber J, Müller CA, Knecht S, Schwartz I, Weigt M, Bock M, von Elverfeldt D, Zaitsev M, Chekmenev EY, Hövener JB, Martins AF, Schilling F, Reinheckel T, Schmidt AB.
  Theranostics. 2025 Mar 3;15(9):3714-3723.
• Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats.
  Ionescu TM, Amend M, Hafiz R, Maurer A, Biswal B, Wehrl HF, Herfert K.
  Elife. 2025 May 15;13:RP97864.
• Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats.
  Ionescu TM, Amend M, Hafiz R, Maurer A, Biswal B, Wehrl HF, Herfert K.
  Elife. 2025 May 15;13:RP97864.
• Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer.
  Deng S, Kim W, Cheng K, Yang Q, Singh Y, Bae G, Bézière N, Mager L, Kommoss S, Sprengel J, Trautwein C.
  Cancer Metab. 2025 May 13;13(1):21.
• Cryogenic mouse tissue homogenization as an alternative to fresh-frozen biopsy use for genomics, transcriptomics, proteomics and metabolomics.
  Zizmare L, Hofmann U, Jarboui MA, Klose F, Fraschka S, Matthes J, Krüger M, Schaeffeler E, Schwab M, Ueffing M, Pichler BJ, Boldt K, Casadei N, Trautwein C.
  Sci Rep. 2025 Jun 23;15(1):20254.
• PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors.
  Pezzana S, Blaess S, Traenkle B, Schaefer A, Ruoff L, Tako B, Castaneda Vega S, ... , Maurer A, Rothbauer U, Pichler BJ, Kneilling M, Sonanini D.
  Sci Adv. 2025 Jun 27;11(26):eadw1924. doi: 10.1126/sciadv.adw1924.
• Application of IVDr NMR spectroscopy to stratify Parkinson's disease with absolute quantitation of blood serum metabolites and lipoproteins.
  Berezhnoy G, Bae G, Wüst L, Schulte C, Cannet C, Wurster I, Zimmermann M, ... , Schäfer H, Gasser T, Trautwein C.
  Sci Rep. 2025 May 22;15(1):17738.
• Feasibility of in vivo small animal imaging using a clinical total-body PET/CT system.
  Mannheim JG, Lan W, Conti M, Siedler F, Krueger MA, Herfert K, la Fougère C, Schmidt FP.
  EJNMMI Phys. 2025 Jul 23;12(1):71.
• Imidazolium-Based Lipid Analogs as Lipofection Reagents
  Pierau M, Nematswerani R, Dunker C, Glorius F, Junker A.
  Arch Pharm (Weinheim). 2025 Aug;358(8):e70076.
• Geometric immunosuppression in CAR T-cell treatment: Insights from mathematical modeling.
  Bordel-Vozmediano S, Sabir S, Benito-Barca L, Weigelin B, Pérez-García VM.
  Comput Biol Med. 2025 Aug;194:110427.
• Noninvasive Monitoring of Inflammatory Processes by Myeloid Cell-Directed PET Tracers in an Experimental Severe Acute Respiratory Syndrome Coronavirus 2 Infection Model.
  Stammes MA, Koopman G, Wagner TR, Traenkle B, Kaiser PD, Mooij P, van der Werff N, Acar RF, Böszörményi KP, Blaess S, Pezzana S, Reischl G, Maurer A, Langermans JAM, Rothbauer U, Kneilling M, Sonanini D.
  J Nucl Med. 2025 Aug 28:jnumed.
• Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity.
  Silva de Oliveira R, Shupe A, Krause T, Richardo T, Ohland C, Sabachvili M, Bucher K, Hetzer J, Hörner S, Dauch D, Heikenwälder M, Trautwein C, Weber ANR, Klepsch V, McCoy KD, Mager LF.
  Cell Rep. 2025 Sep 23;44(9):116223.
• Fungal infections in focus: accelerating non-invasive imaging from preclinical insights to clinical breakthroughs.
  Michiels L, Shameem M, Vanhoffelen E, Reséndiz-Sharpe A, Johnston SA, Beziere N, Vande Velde G.
  Npj Imaging. 2025 Sep 16;3(1):42.
• Histologic Ex Vivo Validation of the [18F]SITATE Somatostatin Receptor PET Tracer.
  Trautwein NF, Mattern S, Hinterleitner M, Reischl G, Schirrmacher R, Steger V, Nadalin S, Nikolaou K, Schwenck J, Singer S, la Fougère C
  J Nucl Med. 2025 Aug 1;66(8):1204-1209.
• Impact of Naturally Composed and Size-Excluded Hymenoptera Venom Preparations on the Safety and Efficacy of Venom Immunotherapy: A Monocentric Experience.
  Fischer J, Löffelad L, Kranert P, Kneilling M, Volc S.
  Int Arch Allergy Immunol. 2025 Jul 24:1-9.
• Copper-mediated radiochemistry: historical impact, current trends, and future possibilities.
  Bowden GD, Müller M, Herth MM, Sanford MS, Scott PJH.
  Npj Imaging. 2025 Jun 10;3:25.
• Elucidation of the Human Cerebrospinal Fluid Metabolome by Ion Mobility Mass Spectrometry and NMR Spectroscopy.
  Sprengel J, Berezhnoy G, Trautwein C.
  Methods Mol Biol. 2025;2914:229-250.
• B7-H4 ImmunoPET Imaging Tracks Tumor-Associated Macrophage Changes in Prostate Cancer.
  Kumar M, Singh SB, Vasyliv I, Habte F, Kalita M, Alam IS, Koladiya A, Dai SY, James M, Rao J, Beziere N, Daldrup-Link HE.
  Mol Pharm. 2025 Dec 1;22(12):7400-7411.
• High-resolution deuterium metabolic imaging of the human brain at 9.4 T using phase-cycled balanced SSFP spectral-spatial acquisitions.
  Iyyappan Valsala P, Pohmann R, Heule R, Solomakha GA, Avdievich NI, Engelmann J, Kuebler L, Martins AF, Scheffler K.
  Magn Reson Med. 2025 Oct 13.
• Confined cell migration along extracellular matrix space in vivo.
  Chepizhko O, Armengol-Collado JM, Alexander S, Wagena E, Weigelin B, Giomi L, Friedl P, Zapperi S, La Porta CAM.
  Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2414009121.
• P2Y14 Receptor Antagonists: Piperidine Bioisosteres and Mutagenesis-Supported Molecular Modeling.
  Pramanik A, Wen Z, Pavan M, Kurma SH, Karcz T, Lewicki SA, Liu N, Demby T, Gavrilova O, Oliva P, Erlitz KS, Junker A, Jung YH, Chen Z, Salvemini D, Kousouros J, Gao ZG, Fay JF, Jacobson KA.
  ACS Pharmacol Transl Sci. 2025 Aug 25;8(9):3126-3148.
• Many Faces: The Global Landscape of Medicinal Chemistry.
  Ferrins L, Adams A, Junker A.
  ACS Med Chem Lett. 2025 Feb 12;16(3):348-350.
• Naphtho[1,2-b][1,4]diazepinedione-Based P2X4 Receptor Antagonists from Structure-Activity Relationship Studies toward PET Tracer Development.
  Erlitz KS, Prinz AK, Wagner S, Massa J, Dunker C, Höhl M, Griep A, McManus RM, Schelhaas S, Koch O, Junker A.
  J Med Chem. 2025 Apr 10;68(7):6965-7002.
• Translating Research Amidst Transnational Quarrels: Thomas Beyer Talks with Bernd Pichler About the Paths of Translational Sciences.
  Pichler B, Beyer T.
  J Nucl Med. 2025 Nov 3;66(11):1671-1673.
• 68Ga-PSMA-11 DKTK trial contributors. The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their i
  Giesel FL, Koerber SA, Hadaschik B, Kiefer S, ... , Kotzerke J, la Fougère C, Reischl G, ... , Schwamborn K, Radtke JP, Hohenfellner M, Debus J, Weber WA, Haberkorn U, Kopka K, Eiber M
  Eur J Nucl Med Mol Imaging. 2025 Nov 15.
• Plexin C1 modulates metabolic programming for resolution of severe inflammation.
  Körner A, Koeppen M, Kaur J, Fitzgerald JC, Kostidis S, Kaussen T, Trautwein C, Giera M, Bakchoul T, Bernard A, Mirakaj V.
  Cell Commun Signal. 2025 Nov 25.
• Impact of the maximum ring difference on image quality and noise characteristics of a total-body PET/CT scanner.
  Schmidt FP, Mannheim JG, Linder PM, Will P, Kiefer LS, Conti MM, la Fougère C, Rausch IF.
  Z Med Phys. 2025 Aug;35(3):292-303.
• Dedicated 3D-Printed Radioactive Phantoms With 18F-FDG for Ultra-High Resolution PET
  Elmoujarkach E, Seeger S, Morgner L, Schmidt FP, Mannheim JG, Schmidt C, Rafecas M.
  IEEE Transactions on Radiation and Plasma Medical Science Volume: 9, Issue: 3, March 2025