Dr. Marie-Aline Neveu
Curriculum vitae and Publications
Phone: +49 7071 29 87589
Fax: +49 7071 29 4451
Using gold standard and emerging imaging technologies, I explored during the course of my PhD work the impact of different treatments on tumor metabolism in vivo. During this project, I clearly identified the limits of in vitro studies to reflect the in vivo context. Using innovative technologies including 17O MRS, 18F-FDG PET, EPR oximetry and hyperpolarized 13C-pyruvate MRS, I was able to characterize the metabolic phenotype of different tumor models in vivo and highlighted the predominant role of local environment to shape tumor profile in vivo. Beyond the role of the physiological environment, the impact of host cell and the metabolic interplay between host cells and cancer cells represent a new field of research that I wanted to further investigate.
Exploiting my knowledge in molecular imaging obtained during my PhD, my research task is to implement hyperpolarized 13C-MRI and explore the value of this technology to assess the impact of immunotherapy in cancer.