Curriculum vitae and Publications
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The accurate and early diagnosis of Parkinson´s disease remains still challenging as no imaging tracer is available so far to detect α-synuclein pathology in the brain in vivo. My current research focus is to use simultaneous PET/BOLD-fMRI to quantify molecular changes of dopamine receptor occupancy and functional neuronal changes as a marker for presynaptic dysfunction in an α-synuclein overexpression rat model of Parkinson´s disease. Pharmacological challenges can be used to provoke or inhibit dopammine or other neurotransmitter release. The aim is to use information provided by PET and BOLD-fMRI as marker of disease progression and treatment response in therapeutic development of Parkinson´s disease.