Dr. Kristina Herfert
Neurology (Receptor Imaging, Neurodegeneration)
Curriculum vitae and Publications
Phone: +49 7071 29 87680
Fax: +49 7071 29 4451
Genomic imaging in Parkinson's disease and related disorders
The latest advances in genome engineering methodologies based on the CRISPR-associated RNA-guided endonuclease Cas9 and transcription activator like effectors (TALEs) have enabled researchers to interrogate the mammalian DNA in a very precise and simple manner. However, the role of many genes and epigenetic mechanisms in human diseases are not yet fully understood. By combining cutting edge genome engineering and in vivo imaging technologies, my goal is to better understand how genes are involved in the regulation of specific functions in the brain. High resolution PET and MRI are used in these experiments to perform in vivo studies on a molecular level of the functional relationship between receptors, transporters and neurotransmitters in small laboratory animals in a highly sensitive and fully quantitative manner.