Imaging Probe Development
Scientific focus: Synthesis of new PET tracers for α-synuclein aggregates in PD patients’ brain
Curriculum vitae and Publications
Email: federica.bonanno( at )med.uni-tuebingen.de
Phone: +49 7071 29 85262
Fax: +49 7071 29 44551
Parkinson’s disease (PD) is a devastating neurodegenerative movement disorder, that today affects approximately 7-10 million patients worldwide. The pathological hallmark of PD is the brain occlusion due to the deposition of α-synuclein (α-syn) protein in the brain followed by dopaminergic neuronal loss. Like other neurodegenerative disorders, PD is still afflicted by problems with early diagnosis and a lack of effective methods for monitoring both disease progression and the effects of treatment. My research focuses on the development of a new α-syn fibrils targeted positron emission tomography (PET) tracer necessary to establish a non-invasive in vivo imaging method that allows visualization of the abnormal α-syn protein brain content.