In press

GABAergic astrocytes in Alzheimer's disease, Garaschuk O, Verkhratsky A, Aging (2019, jn press

2019

Healthy Brain Aging Modifies Microglial Calcium Signaling In VivoFigarella K, Uzcategui NL, Mogk S, Wild K, Fallier-Becker P, Neher Jonas J, Duszenko M,  Neurobiology of Disease, 01/2019 Volume 121, p. 315-326

Role of intracellular calcium stores for an impairment of visual processing in a mouse model of Alzheimer's diseaseAsavapanumas N, Brawek B, Martus P, Garaschuk O, Neurobiology of Disease, 01/2019 Volume 121, p. 315-326

2018

Morphological changes, nitric oxide production, and phagocytosis are triggered in vitro in microglia by bloodstream forms of Trypanosoma burceiFigarella K, Uzcategui N, Mogk S, Wild K, Fallier-Becker P, Neher J, Duszenko M, Scientific Reports (2018)

Role of presynaptic calcium stores for neural network dysfunction in Alzheimer's diseaseGaraschuk O & Lerdkrai C, Neural Regeneration Research, Neural Regeneration Research, 06/2018

Spontaneous calcium transients in the immature adult-born neurons of the olfactory bulb. Maslyukov A, Li K, Su X, Kovalchuk Y, Garaschuk O, Cell Calcium, 06/2018 Volume 74, p. 43-52

Healthy brain ageing: interplay between reactive species, inflammation and energy supply. O Garaschuk, HM Semchyshyn and VI Lushchak, Ageing Research Reviews, 05/2018, Volume 43, p. 26-45 

Intracellular calcium stores control in vivo neuroanl hyperactivity in a mouse of Alzheimer's disease. C Lerdkrai, N Asavapanumas, B Brawek, Y Kovalchuk, N Mojtahedi M Olmedillas-del-Moral and O Garaschuk, PNAS USA,  01/2018 

A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease. Brawek B, Chersters R, Klement D, Müller J, Lerdkrai C, Hermes M, Garaschuk O, Neurobiol Aging,  Oct 6;61:187-197. doi: 10.1016/j.neurobiolaging.2017.09.028

2017

Age-related changes in microglial physiology: the role for healthy brain ageing and neurodegenerative disorders. Garaschuk O, eNeuroforum, Band 23, Heft 4,  2017 Nov doi: doi.org/10.1515/nf-2016-A057 

A new approach for ratiometric in vivo calcium imaging of microglia. Brawek B, Liang Y, Savitska D, Li K, Fomin-Thunemann N, Kovaclhuk Y, Zirdum E, Jakobsson J, Garaschuk O, Scientific Reports , 2017 Jul 20;7(1):6030. doi: 10.1038/s41598-017-05952-3.

Altersbedingte Veränderungen der Mirkogliazellen: ihre Rolle bei gesundem Altern des Gehirns und bei neurodegenerativen Erkrankungen. O Garaschuk, Neuroforu, 23/11/2017, Volume 23(4), p. 239-248

Monitoring in vivo function of cortical microglia. Brawek B, Garaschuk O. Cell Calcium, Volume 64, p.109-117, (2017)

Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain. Askew K, Li K, Olmos-Alonso A, Garcia-Morreno F, Y, Liang, Richardson P, Tipton T, Chapman MA, Riecken K, Beccari S, Sierra A, Molnár Z, Cragg MS, Garaschuk O, Perry VH, Gomez-Nicola D. Cell Reports,  Volume 18 (2017)

2016

Long-term in vivo single cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb, Y, Liang, K Li, K Riecken, A Maslyukov, D Gomez-Nicola, Y Kovalchuk, B Fehse, and O Garaschuk , Cell Research, (2016) RTF Tagged XML BibTex Google Scholar

2015

Brain tumor cells interconnect to a functional and resistant network, M, Osswald, E Jung, F Sahm, G Solecki, V Venkataramani, J Blaes, S Weil, H Horstmann, B Wiestler, M Syed, et al. , Nature, 2015 Dec 3, Volume 528, p.93-8, (2015) Abstract RTF Tagged XML BibTex Google Scholar

GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo., K, Kirmse, M Kummer, Y Kovalchuk, OW Witte, O Garaschuk, and K Holthoff , Nature Communications , 07/2015, Volume 6, (2015) Abstract RTF Tagged XML BibTex Google Scholar

In vivo odorant response properties of migrating adult-born neurons in the mouse olfactory bulb, Y, Kovalchuk, R Homma, Y Liang, A Maslyukov, M Hermes, T Thestrup, O Griesbeck, J Ninkovic, LB Cohen, and O Garaschuk , Nature Communications , (2015) Abstract RTF Tagged XML BibTex Google Scholar

Neuroinflammation in Alzheimer's Disease, M.T, Heneka, M.J Carson, J El Khoury, G.E Landreth, F Brosseron, D.L Feinstein, A.H Jacobs, T Wyss-Coray, J Vitorica, R.M Ransohoff, et al. , Lancet Neurology, Volume 14, (2015) Abstract RTF Tagged XML BibTex Google Scholar

2014

Impairment of in vivo calcium signaling in amyloid plaque-associated microglia, B, Brawek, B Schwendele, K Riester, S Kohsaka, C Lerdkrai, Y Liang, and O Garaschuk , Acta Neuropathologica, April 2014, Volume 127, Issue 4, p.495-505, (2014) RTF Tagged XML BibTex Google Scholar

Imaging Morphology and Function of Cortical Microglia, Brawek, B., and Garaschuk O. , Optical Imaging of Neocortical Dynamics, Volume 85, p.209-223 , (2014) RTF Tagged XML BibTex Google Scholar

Longitudinal PET/MRI reveals -amyloid deposition and rCBF dynamics, and connects vascular amyloidosis to quantitative loss of perfusion, F.C, Maier, H.F Wehrl, A.M Schmid, J.G Mannheim, S Wiehr, C Lerdkrai, C Calaminus, A Stahlschmidt, L Ye, M Burnet, et al. , Nat Med, p.doi:10.1038/nm.3734, (2014) RTF Tagged XML BibTex Google Scholar

Network-wide dysregulation of calcium homeostasis in Alzheimer's disease, B, Brawek, and O Garaschuk , Cell & Tissue Research, p.427-438, (2014) RTF Tagged XML BibTex Google Scholar

Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes, T, Thestrup, J Litzlbauer, I Bartholomäus, M Mues, L Russo, H Dana, Y Kovalchuk, Y Liang, G Kalamakis, Y Laukat, et al. , Nat Methods, p.175-182, (2014) RTF Tagged XML BibTex Google Scholar

2013

In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb, R, Homma, Y Kovalchuk, A Konnerth, LB Cohen, and O Garaschuk , Frontiers in Neural Circuits, 21 February 2013, Volume 7, p.1-23, (2013) Abstract RTF Tagged XML BibTex Google Scholar

Imaging microcircuit function in healthy and diseased brain, O, Garaschuk , Experimental Neurology, Volume 242, p.41-49, (2013) RTF Tagged XML BibTex Google Scholar

Microglial calcium signaling in the adult, aged and diseased brain, B, Brawek, and O Garaschuk , Cell Calcium , p.159-169, (2013) RTF Tagged XML BibTex Google Scholar

2012

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells., NH, Varvel, SA Grathwohl, F Baumann, C Liebig, A Bosch, B Brawek, DR Thal, IF Charo, FL Heppner, A Aguzzi, et al. , Proc Natl Acad Sci USA, 2012 Oct 15, p.18150-18155, (2012) Abstract RTF Tagged XML BibTex Google Scholar

High resolution in vivo imaging of microglia using a versatile non genetically-encoded marker., Schwendele, Bernd, Brawek Bianca, Hermes Marina, and Garaschuk Olga , European journal of immunology, p.2193-2196, (2012) Abstract RTF Tagged XML BibTex Google Scholar

In vivo functional imaging of the olfactory bulb at single cell resolution, S, Fink, Y Kovalchuk, R Homma, B Schwendele, S Direnberger, LB Cohen, O Griesbeck, and O Garaschuk , Neuronal Network Analysis, Volume 67, p.21-43, (2012) RTF Tagged XML BibTex Google Scholar

Sound-evoked network calcium transients in mouse auditory cortex in vivo., C, Grienberger, H Adelsberger, A Stroh, Milos R. I., O Garaschuk, A Schierloh, I Nelken, and A Konnerth , Journal of Physiology , Volume 590, p.899-918, (2012) Abstract RTF Tagged XML BibTex Google Scholar

Two-Photon Chloride Imaging Using MQAE In Vitro and In Vivo, Y, Kovalchuk, and O Garaschuk , Cold Spring Harb Protoc., p.778-785, (2012) RTF Tagged XML BibTex Google Scholar

2011

Two-photon imaging of neural networks in a mouse model of Alzheimer's disease., G, Eichhoff, and O Garaschuk , Cold Spring Harb Protoc, Oct 1, 2011, p.1206-1216, (2011) RTF Tagged XML BibTex Google Scholar

Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo., Eichhoff, Gerhard, Brawek Bianca, and Garaschuk Olga , Biochimica et biophysica acta - Molecular Cell Research, 2011, May, p.1014-1024, (2011) Abstract RTF Tagged XML BibTex Google Scholar PubMed

Two-photon chloride imaging using MQAE in vitro and in vivo., Kovalchuk, Y., and Garaschuk O. , Imaging in Neuroscience: A Laboratory Manual, 2011 May, p.623-632, (2011) Abstract RTF Tagged XML BibTex Google Scholar

Two-Photon Imaging of Neural Networks in a Mouse Model of Alzheimer's Disease, Eichhoff, G., and Garaschuk O. , Imaging in Neuroscience: A Laboratory Manual, 2011 May, p.999-1010, (2011) Abstract RTF Tagged XML BibTex Google Scholar

2010

Intracellular calcium signalling in Alzheimer's disease, Hermes, M., Eichhoff G., and Garaschuk O. , J Cell Mol Med, Jan, Volume 14, Number 1-2, p.30-41, (2010) Abstract RTF Tagged XML BibTex Google Scholar

Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK cannels., Chen, Xiaowei, Kovalchuk Yury, Adelsberger Helmuth, Henning Horst A., Sausbier Matthias, Wietzorrek Georg, Ruth Peter, Yarom Yosef, and Konnerth Arthur , Proceedings of the National Academy of Sciences of the United States of America, 06/2010, Volume 107, Issue 27, p.12323-12328, (2010) Abstract RTF Tagged XML BibTex Google Scholar PubMed

In vivo Ca2+ imaging of the living brain using multi-cell bolus loading technique, Eichhoff, G., Kovalchuk Y., Varga Z., Verkhratsky A., and Garaschuk O. , Calcium Measurement Methods, Volume 43, New York, p.205-220, (2010) Abstract RTF Tagged XML BibTex Google Scholar

In vivo two-photon calcium imaging using multi-cell bolus loading technique, Garaschuk, O., and Konnerth A. , Cold Spring Harb Protoc, p.pdb prot5482, (2010) Abstract RTF Tagged XML BibTex Google Scholar

Monitoring Calcium Levels With Genetically Encoded Indicators, Garaschuk, O., and Griesbeck O. , Neuromethods series: Calcium measurements in neural cells, Volume 101-118, New York, (2010) RTF Tagged XML BibTex Google Scholar

2009

Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes, Homma, R., Baker B. J., Jin L., Garaschuk O., Konnerth A., Cohen L. B., and Zecevic D. , Philos Trans R Soc Lond B Biol Sci, Sep 12, Volume 364, Number 1529, p.2453-2467, (2009) Abstract RTF Tagged XML BibTex Google Scholar

Sparsification of neuronal activity in the visual cortex at eye-opening., Rochefort, N.l., Garaschuk, O., Milos, R.I., Narushima, M., Marandi, N., Pichler, B., Kovalchuk, Y., and Konnerth A. , Proc. Natl. Acad. Sci. USA, Volume 106, Issue 35, p.15049-15054, (2009) Abstract RTF Tagged XML BibTex Google Scholar

Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes, Homma, R., Baker B. J., Jin L., Garaschuk O., Konnerth A., Cohen L. B., Bleau C. X., Canepari M., Djurisic M., and Zecevic D. , Methods Mol Biol, Volume 489, p.43-79, (2009) Abstract RTF Tagged XML BibTex Google Scholar

2008

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease, Busche, M. A., Eichhoff G., Adelsberger H., Abramowski D., Wiederhold K. H., Haass C., Staufenbiel M., Konnerth A., and Garaschuk O. , Science, Sep 19, Volume 321, Number 5896, p.1686-1689, (2008) Abstract RTF Tagged XML BibTex Google Scholar

In vivo calcium imaging of the aging and diseased brain, Eichhoff, G., Busche M. A., and Garaschuk O. , Eur J Nucl Med Mol Imaging, Volume 35 Suppl 1, p.S99-106, (2008) RTF Tagged XML BibTex Google Scholar

2007

Troponin C-based biosensors: A new family of genetically encoded indicators for in vivo calcium imaging in the nervous system, Garaschuk, O., Griesbeck O., and Konnerth A. , Cell Calcium, Oct-Nov, Volume 42, Number 4-5, p.351-361, (2007) Abstract RTF Tagged XML BibTex Google Scholar

Improved calcium imaging in transgenic mice expressing a troponin-C based biosensor, Heim, N., Garaschuk O., Friedrich M. W., Mank M., Milos R. I., Kovalchuk Y., Konnerth A., and Griesbeck O. , Nature Methods, Volume 4, p.127 - 129, (2007) RTF Tagged XML BibTex Google Scholar

2006

Optical monitoring of brain function in vivo: from neurons to networks, Garaschuk, O., Milos R. I., Grienberger C., Marandi N., Adelsberger H., and Konnerth A. , Pflugers Arch, Dec, Volume 453, Number 3, p.385-396, (2006) Abstract RTF Tagged XML BibTex Google Scholar

Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo, Garaschuk, O., Milos R. I., and Konnerth A. , Nat Protoc, Volume 1, p.380-386, (2006) RTF Tagged XML BibTex Google Scholar

2005

Cortical calcium waves in resting newborn mice, Adelsberger, H., Garaschuk O., and Konnerth A. , Nat Neurosci, Jul 10, Volume 8, p.988-990, (2005) Abstract RTF Tagged XML BibTex Google Scholar

A practical guide: In vivo two-photon calcium imaging using multi-cell bolus loading, Garaschuk, O., and Konnerth A. , Imaging in Neuroscience and Development: A Laboratory Manual., p.645-648, (2005) RTF Tagged XML BibTex Google Scholar

Two-photon imaging of chloride, Garaschuk, O., and Konnerth A. , Imaging in Neuroscience and Development: A Laboratory Manual., p.535-538, (2005) RTF Tagged XML BibTex Google Scholar

2004

Novel approaches to monitor and manipulate single neurons in vivo, Brecht, M., Fee M. S., Garaschuk O., Helmchen F., Margrie T. W., Svoboda K., and Osten P. , J Neurosci, Oct 20, Volume 24, Number 42, p.9223-9227, (2004) RTF Tagged XML BibTex Google Scholar

2003

In vivo two-photon calcium imaging of neuronal networks, Stosiek, C., Garaschuk O., Holthoff K., and Konnerth A. , Proc Natl Acad Sci U S A, Jun 10, Volume 100, Number 12, p.7319-7324, (2003) Abstract RTF Tagged XML BibTex Google Scholar

In vivo two-photon calcium imaging using multi-cell bolus loading., Garaschuk, O., and Konnerth A. , Imaging in Neuroscience and Development: A Laboratory Manual., (2003) RTF Tagged XML BibTex Google Scholar

Two-photon chloride imaging using the quinolinium-based indicator dye MQAE, Garaschuk, O., and Konnerth A. , Imaging in Neuroscience and Development: A Laboratory Manual., (2003) RTF Tagged XML BibTex Google Scholar

2002

Two-photon chloride imaging in neurons of brain slices, Marandi, N., Konnerth A., and Garaschuk O. , Pflugers Arch, Volume 445, Number 3, p.357-365., (2002) Abstract RTF Tagged XML BibTex Google Scholar

2000

Large-scale oscillatory calcium waves in the immature cortex, Garaschuk, O., Linn J., Eilers J., and Konnerth A. , Nat Neurosci, Volume 3, Number 5, p.452-459, (2000) Abstract RTF Tagged XML BibTex Google Scholar

Measuring calcium fluxes in dendritic domaines of neurones in brain slices, Garaschuk, O., and Konnerth A. , <i>Imaging: a Laboratory Manual</i>, p.36.1-36.11, (2000) RTF Tagged XML BibTex Google Scholar